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Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms.
Clin Drug Investig. 2013 Jan; 33(1):71-91.CD

Abstract

Propiverine is a well established antimuscarinic agent with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). As well as blocking muscarinic receptors in the detrusor muscle, the drug also inhibits cellular calcium influx, thereby diminishing muscle spasm. In patients with symptoms of OAB resulting from idiopathic detrusor overactivity (IDO) or neurogenic detrusor overactivity (NDO), propiverine demonstrated dose-dependent efficacy and tolerability, with adverse events consistent with those associated with all antimuscarinic agents. In adults with IDO, propiverine demonstrated similar efficacy to that of other antimuscarinic agents (including solifenacin, tolterodine, oxybutynin and imidafenacin) and, in adults with NDO, propiverine and oxybutynin demonstrated similar efficacy. Propiverine was generally well tolerated in these patient populations, with a lower incidence of dry mouth than that associated with oxybutynin. In men with lower urinary tract symptoms (LUTS), and in whom the presence of benign prostatic enlargement (BPE) was implicated, propiverine administered as add-on therapy to an α(1)-adrenoceptor antagonist demonstrated similar or superior efficacy to that achieved with an α(1)-adrenoceptor antagonist alone, and combination therapy was particularly effective in patients with urinary storage symptoms. Combination therapy was generally well tolerated, but was associated with a higher incidence of adverse events than an α(1)-adrenoceptor antagonist alone. In children and adolescents with IDO/OAB or NDO, propiverine was generally more effective and better tolerated than oxybutynin. In conclusion, propiverine provides a valuable option for the treatment of adults and children with OAB associated with IDO or NDO, and in men with storage LUTS.

Authors+Show Affiliations

cdi@adis.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23288694

Citation

McKeage, Kate. "Propiverine: a Review of Its Use in the Treatment of Adults and Children With Overactive Bladder Associated With Idiopathic or Neurogenic Detrusor Overactivity, and in Men With Lower Urinary Tract Symptoms." Clinical Drug Investigation, vol. 33, no. 1, 2013, pp. 71-91.
McKeage K. Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms. Clin Drug Investig. 2013;33(1):71-91.
McKeage, K. (2013). Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms. Clinical Drug Investigation, 33(1), 71-91. https://doi.org/10.1007/s40261-012-0046-9
McKeage K. Propiverine: a Review of Its Use in the Treatment of Adults and Children With Overactive Bladder Associated With Idiopathic or Neurogenic Detrusor Overactivity, and in Men With Lower Urinary Tract Symptoms. Clin Drug Investig. 2013;33(1):71-91. PubMed PMID: 23288694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms. A1 - McKeage,Kate, PY - 2013/1/5/entrez PY - 2013/1/5/pubmed PY - 2013/7/3/medline SP - 71 EP - 91 JF - Clinical drug investigation JO - Clin Drug Investig VL - 33 IS - 1 N2 - Propiverine is a well established antimuscarinic agent with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). As well as blocking muscarinic receptors in the detrusor muscle, the drug also inhibits cellular calcium influx, thereby diminishing muscle spasm. In patients with symptoms of OAB resulting from idiopathic detrusor overactivity (IDO) or neurogenic detrusor overactivity (NDO), propiverine demonstrated dose-dependent efficacy and tolerability, with adverse events consistent with those associated with all antimuscarinic agents. In adults with IDO, propiverine demonstrated similar efficacy to that of other antimuscarinic agents (including solifenacin, tolterodine, oxybutynin and imidafenacin) and, in adults with NDO, propiverine and oxybutynin demonstrated similar efficacy. Propiverine was generally well tolerated in these patient populations, with a lower incidence of dry mouth than that associated with oxybutynin. In men with lower urinary tract symptoms (LUTS), and in whom the presence of benign prostatic enlargement (BPE) was implicated, propiverine administered as add-on therapy to an α(1)-adrenoceptor antagonist demonstrated similar or superior efficacy to that achieved with an α(1)-adrenoceptor antagonist alone, and combination therapy was particularly effective in patients with urinary storage symptoms. Combination therapy was generally well tolerated, but was associated with a higher incidence of adverse events than an α(1)-adrenoceptor antagonist alone. In children and adolescents with IDO/OAB or NDO, propiverine was generally more effective and better tolerated than oxybutynin. In conclusion, propiverine provides a valuable option for the treatment of adults and children with OAB associated with IDO or NDO, and in men with storage LUTS. SN - 1179-1918 UR - https://www.unboundmedicine.com/medline/citation/23288694/Propiverine:_a_review_of_its_use_in_the_treatment_of_adults_and_children_with_overactive_bladder_associated_with_idiopathic_or_neurogenic_detrusor_overactivity_and_in_men_with_lower_urinary_tract_symptoms_ L2 - https://dx.doi.org/10.1007/s40261-012-0046-9 DB - PRIME DP - Unbound Medicine ER -