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Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients.
Int J Med Sci. 2013; 10(1):79-89.IJ

Abstract

BACKGROUND

Patients undergoing hemodialysis (HD) have low plasma levels of zinc (Zn), high plasma levels of copper (Cu), and exhibit increased oxidative stress, inflammation, and immune abnormalities. We evaluated the effects of Zn supplementation on abnormal plasma Cu/Zn ratios and clinical outcomes in HD patients.

DESIGN AND METHODS

Patients on long-term HD with lower than normal plasma concentrations of Zn (< 80 mg/dL) were randomized to receive daily oral Zn supplements (n = 40) or no supplements (n = 25) for eight weeks. Age- and sex-matched healthy individuals served as a control group (n = 38). A number of clinical parameters were measured before and after the supplementation period.

RESULTS

Compared with healthy subjects, patients had significantly elevated plasma Cu concentrations and Cu/Zn ratios, as well as higher levels of oxidative stress and pro-inflammatory cytokines. Patients who received Zn supplements for eight weeks had higher plasma concentrations of Zn and lower concentrations of Cu, along with reduced Cu/Zn ratios, oxidative stress status, and inflammatory responses compared to patients who did not receive Zn. Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios.

CONCLUSIONS

Zn supplementation ameliorates abnormally high plasma Cu/Zn ratios and may reduce oxidative stress, improve inflammatory status, and maintain immune function in patients undergoing long-term HD.

Authors+Show Affiliations

Micro-Nutrition Lab, Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan, Republic of China.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23289009

Citation

Guo, Chih-Hung, and Chia-Liang Wang. "Effects of Zinc Supplementation On Plasma Copper/zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients." International Journal of Medical Sciences, vol. 10, no. 1, 2013, pp. 79-89.
Guo CH, Wang CL. Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients. Int J Med Sci. 2013;10(1):79-89.
Guo, C. H., & Wang, C. L. (2013). Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients. International Journal of Medical Sciences, 10(1), 79-89. https://doi.org/10.7150/ijms.5291
Guo CH, Wang CL. Effects of Zinc Supplementation On Plasma Copper/zinc Ratios, Oxidative Stress, and Immunological Status in Hemodialysis Patients. Int J Med Sci. 2013;10(1):79-89. PubMed PMID: 23289009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of zinc supplementation on plasma copper/zinc ratios, oxidative stress, and immunological status in hemodialysis patients. AU - Guo,Chih-Hung, AU - Wang,Chia-Liang, Y1 - 2012/12/22/ PY - 2012/09/25/received PY - 2012/12/19/accepted PY - 2013/1/5/entrez PY - 2013/1/5/pubmed PY - 2013/7/16/medline KW - copper/zinc ratios KW - hemodialysis patients. KW - immune function KW - inflammation KW - oxidative stress KW - zinc supplement SP - 79 EP - 89 JF - International journal of medical sciences JO - Int J Med Sci VL - 10 IS - 1 N2 - BACKGROUND: Patients undergoing hemodialysis (HD) have low plasma levels of zinc (Zn), high plasma levels of copper (Cu), and exhibit increased oxidative stress, inflammation, and immune abnormalities. We evaluated the effects of Zn supplementation on abnormal plasma Cu/Zn ratios and clinical outcomes in HD patients. DESIGN AND METHODS: Patients on long-term HD with lower than normal plasma concentrations of Zn (< 80 mg/dL) were randomized to receive daily oral Zn supplements (n = 40) or no supplements (n = 25) for eight weeks. Age- and sex-matched healthy individuals served as a control group (n = 38). A number of clinical parameters were measured before and after the supplementation period. RESULTS: Compared with healthy subjects, patients had significantly elevated plasma Cu concentrations and Cu/Zn ratios, as well as higher levels of oxidative stress and pro-inflammatory cytokines. Patients who received Zn supplements for eight weeks had higher plasma concentrations of Zn and lower concentrations of Cu, along with reduced Cu/Zn ratios, oxidative stress status, and inflammatory responses compared to patients who did not receive Zn. Patients receiving Zn also showed significantly higher percentages of CD4 and CD19 lymphocytes, and elevated CD4/CD8 ratios. CONCLUSIONS: Zn supplementation ameliorates abnormally high plasma Cu/Zn ratios and may reduce oxidative stress, improve inflammatory status, and maintain immune function in patients undergoing long-term HD. SN - 1449-1907 UR - https://www.unboundmedicine.com/medline/citation/23289009/Effects_of_zinc_supplementation_on_plasma_copper/zinc_ratios_oxidative_stress_and_immunological_status_in_hemodialysis_patients_ L2 - https://www.medsci.org/v10p0079.htm DB - PRIME DP - Unbound Medicine ER -