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Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.

Abstract

Low seminal plasma concentrations of coenzyme Q10 (CoQ10) have been correlated with impaired sperm parameters, but the exact mechanism remains of dominating interest. This randomised, placebo-controlled study examined the effect of CoQ10 on catalase, superoxide dismutase (SOD) and F2 -isoprostanes in seminal plasma in infertile men and their relation with CoQ10 concentration. Sixty infertile men with idiopathic oligoasthenoteratozoospermia (OAT) were randomised to receive 200 mg d(-1) of CoQ10 or placebo for 3 months. 47 persons of them completed the study. Semen analysis, anthropometric measurements, diet and physical activity assessment were performed for subjects before and after treatment. Independent and paired t-test, chi-square test and ancova were compared outcomes of supplementation between two groups. CoQ10 levels increased from 44.74 ± 36.47 to 68.17 ± 42.41 ng ml(-1) following supplementation in CoQ10 (P < 0.001). CoQ10 group had higher catalase and SOD activity than the placebo group. There was a significant positive correlation between CoQ10 concentration and normal sperm morphology (P = 0.037), catalase (P = 0.041) and SOD (P < 0.001). Significant difference was shown between the mean of changes in seminal plasma 8-isoprostane in two groups (P = 0.003) after supplementation. Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

    , , , , , , ,

    Source

    Andrologia 46:2 2014 Mar pg 177-83

    MeSH

    Adult
    Antioxidants
    Catalase
    Dinoprost
    Double-Blind Method
    Humans
    Infertility, Male
    Male
    Oxidative Stress
    Semen
    Sperm Motility
    Superoxide Dismutase
    Ubiquinone

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    23289958

    Citation

    Nadjarzadeh, A, et al. "Effect of Coenzyme Q10 Supplementation On Antioxidant Enzymes Activity and Oxidative Stress of Seminal Plasma: a Double-blind Randomised Clinical Trial." Andrologia, vol. 46, no. 2, 2014, pp. 177-83.
    Nadjarzadeh A, Shidfar F, Amirjannati N, et al. Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia. 2014;46(2):177-83.
    Nadjarzadeh, A., Shidfar, F., Amirjannati, N., Vafa, M. R., Motevalian, S. A., Gohari, M. R., ... Sadeghi, M. R. (2014). Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia, 46(2), pp. 177-83. doi:10.1111/and.12062.
    Nadjarzadeh A, et al. Effect of Coenzyme Q10 Supplementation On Antioxidant Enzymes Activity and Oxidative Stress of Seminal Plasma: a Double-blind Randomised Clinical Trial. Andrologia. 2014;46(2):177-83. PubMed PMID: 23289958.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. AU - Nadjarzadeh,A, AU - Shidfar,F, AU - Amirjannati,N, AU - Vafa,M R, AU - Motevalian,S A, AU - Gohari,M R, AU - Nazeri Kakhki,S A, AU - Akhondi,M M, AU - Sadeghi,M R, Y1 - 2013/01/07/ PY - 2012/11/06/accepted PY - 2013/1/8/entrez PY - 2013/1/8/pubmed PY - 2014/9/30/medline KW - Antioxidant enzymes KW - isoprostane KW - male infertility KW - oxidative stress KW - ubiquinone SP - 177 EP - 83 JF - Andrologia JO - Andrologia VL - 46 IS - 2 N2 - Low seminal plasma concentrations of coenzyme Q10 (CoQ10) have been correlated with impaired sperm parameters, but the exact mechanism remains of dominating interest. This randomised, placebo-controlled study examined the effect of CoQ10 on catalase, superoxide dismutase (SOD) and F2 -isoprostanes in seminal plasma in infertile men and their relation with CoQ10 concentration. Sixty infertile men with idiopathic oligoasthenoteratozoospermia (OAT) were randomised to receive 200 mg d(-1) of CoQ10 or placebo for 3 months. 47 persons of them completed the study. Semen analysis, anthropometric measurements, diet and physical activity assessment were performed for subjects before and after treatment. Independent and paired t-test, chi-square test and ancova were compared outcomes of supplementation between two groups. CoQ10 levels increased from 44.74 ± 36.47 to 68.17 ± 42.41 ng ml(-1) following supplementation in CoQ10 (P < 0.001). CoQ10 group had higher catalase and SOD activity than the placebo group. There was a significant positive correlation between CoQ10 concentration and normal sperm morphology (P = 0.037), catalase (P = 0.041) and SOD (P < 0.001). Significant difference was shown between the mean of changes in seminal plasma 8-isoprostane in two groups (P = 0.003) after supplementation. Three-month supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress in seminal plasma and improve semen parameters and antioxidant enzymes activity. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/23289958/Effect_of_Coenzyme_Q10_supplementation_on_antioxidant_enzymes_activity_and_oxidative_stress_of_seminal_plasma:_a_double_blind_randomised_clinical_trial_ L2 - https://doi.org/10.1111/and.12062 DB - PRIME DP - Unbound Medicine ER -