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Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study.
Diab Vasc Dis Res. 2013 Jul; 10(4):324-9.DV

Abstract

OBJECTIVE

To evaluate the risk of cardiovascular events in diabetes defined by isolated post-challenge hyperglycaemia (IPH).

METHODS

We followed 3794 subjects aged ≥40 years without known history of diabetes or cardiovascular disease (CVD) at baseline for CVD events. Participants were categorized as subjects without diabetes [fasting plasma glucose (FPG) < 126 mg/dL and 2-h post-challenge plasma glucose (2-hPG) < 200 mg/dL], IPH (FPG < 126 mg/dL and 2-h PG ≥ 200 mg/dL) and fasting hyperglycaemia (fasting blood glucose (FBS) ≥ 126 mg/dL). Hazard ratios (HRs) were calculated with the use of Cox proportional-hazards regression models to evaluate the risk of CVD events.

RESULTS

At baseline, of 486 subjects with newly diagnosed diabetes, 190 (39%) had IPH. Over the next 8 years, age and sex-adjusted HR for incident CVD was 1.77 (95% confidence interval (CI): 1.19-2.64; p = 0.005) in subjects with IPH compared with subjects without diabetes. After further adjustment for potential confounders, the HR for CVD was not significant [1.32 (95% CI: 0.88-1.99; p = 0.2)].

CONCLUSIONS

IPH in middle-aged adults adds nothing for identifying CVD risks when other risk factors are taken into account. Associated metabolic risk factors seem to be more important than hyperglycaemia per se.

Authors+Show Affiliations

Obesity Research Center, Research Institute for Endocrine Science, Shahid Beheshti University of Medical Science, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23291339

Citation

Barzin, Maryam, et al. "Isolated Post-challenge Hyperglycaemia and Risk of Cardiovascular Events: Tehran Lipid and Glucose Study." Diabetes & Vascular Disease Research, vol. 10, no. 4, 2013, pp. 324-9.
Barzin M, Hosseinpanah F, Malboosbaf R, et al. Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study. Diab Vasc Dis Res. 2013;10(4):324-9.
Barzin, M., Hosseinpanah, F., Malboosbaf, R., Hajsheikholeslami, F., & Azizi, F. (2013). Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study. Diabetes & Vascular Disease Research, 10(4), 324-9. https://doi.org/10.1177/1479164112469639
Barzin M, et al. Isolated Post-challenge Hyperglycaemia and Risk of Cardiovascular Events: Tehran Lipid and Glucose Study. Diab Vasc Dis Res. 2013;10(4):324-9. PubMed PMID: 23291339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study. AU - Barzin,Maryam, AU - Hosseinpanah,Farhad, AU - Malboosbaf,Ramin, AU - Hajsheikholeslami,Farhad, AU - Azizi,Fereidoun, Y1 - 2013/01/04/ PY - 2013/1/8/entrez PY - 2013/1/8/pubmed PY - 2013/11/10/medline KW - Isolated post-challenge hyperglycaemia KW - cardiovascular events KW - diabetes KW - fasting hyperglycaemia SP - 324 EP - 9 JF - Diabetes & vascular disease research JO - Diab Vasc Dis Res VL - 10 IS - 4 N2 - OBJECTIVE: To evaluate the risk of cardiovascular events in diabetes defined by isolated post-challenge hyperglycaemia (IPH). METHODS: We followed 3794 subjects aged ≥40 years without known history of diabetes or cardiovascular disease (CVD) at baseline for CVD events. Participants were categorized as subjects without diabetes [fasting plasma glucose (FPG) < 126 mg/dL and 2-h post-challenge plasma glucose (2-hPG) < 200 mg/dL], IPH (FPG < 126 mg/dL and 2-h PG ≥ 200 mg/dL) and fasting hyperglycaemia (fasting blood glucose (FBS) ≥ 126 mg/dL). Hazard ratios (HRs) were calculated with the use of Cox proportional-hazards regression models to evaluate the risk of CVD events. RESULTS: At baseline, of 486 subjects with newly diagnosed diabetes, 190 (39%) had IPH. Over the next 8 years, age and sex-adjusted HR for incident CVD was 1.77 (95% confidence interval (CI): 1.19-2.64; p = 0.005) in subjects with IPH compared with subjects without diabetes. After further adjustment for potential confounders, the HR for CVD was not significant [1.32 (95% CI: 0.88-1.99; p = 0.2)]. CONCLUSIONS: IPH in middle-aged adults adds nothing for identifying CVD risks when other risk factors are taken into account. Associated metabolic risk factors seem to be more important than hyperglycaemia per se. SN - 1752-8984 UR - https://www.unboundmedicine.com/medline/citation/23291339/Isolated_post_challenge_hyperglycaemia_and_risk_of_cardiovascular_events:_Tehran_Lipid_and_Glucose_Study_ L2 - http://journals.sagepub.com/doi/full/10.1177/1479164112469639?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -