Tags

Type your tag names separated by a space and hit enter

Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats.
Neuroscience. 2013 Mar 13; 233:86-94.N

Abstract

Caffeic acid phenethyl ester (CAPE) is a botanical compound abundant in honeybees' propolis. It has anti-inflammatory, antiviral, antioxidant, immunomodulatory and antitumor properties. Its beneficial effects against neurodegenerative diseases, including Parkinson's disease, have also been suggested and some mechanisms have been proposed. Mitochondrial damage and oxidative stress are critical events in neurodegeneration. Release of cytochrome c from mitochondria to cytosol and the downstream activation of caspase-3 have been suggested as targets of the protective mechanism of CAPE. Most of the studies addressing the protective effect of CAPE have been performed in cell culture. This is the first study to demonstrate the protective effect of CAPE against the dopaminergic neuronal loss induced by 6-hydroxydopamine (6-OHDA) in rats. It also demonstrates, for the first time, the inhibitory effect of CAPE on mitochondrial permeability transition (MPT), a mediator of neuronal death that triggers cytochrome c release and caspase-3 activation. Scavenging of reactive oxygen species (ROS) and metal chelation was demonstrated in the brain-affected areas of the rats treated with 6-OHDA and CAPE. Additionally, we demonstrated that CAPE does not affect brain mitochondrial function. Based on these findings and on its ability to cross the blood-brain barrier, CAPE is a promising compound to treat Parkinson's and other neurodegenerative diseases.

Authors+Show Affiliations

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Avenida do Café s/n, 14040-903 Ribeirão Preto, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23291456

Citation

Barros Silva, R, et al. "Caffeic Acid Phenethyl Ester Protects Against the Dopaminergic Neuronal Loss Induced By 6-hydroxydopamine in Rats." Neuroscience, vol. 233, 2013, pp. 86-94.
Barros Silva R, Santos NA, Martins NM, et al. Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats. Neuroscience. 2013;233:86-94.
Barros Silva, R., Santos, N. A., Martins, N. M., Ferreira, D. A., Barbosa, F., Oliveira Souza, V. C., Kinoshita, A., Baffa, O., Del-Bel, E., & Santos, A. C. (2013). Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats. Neuroscience, 233, 86-94. https://doi.org/10.1016/j.neuroscience.2012.12.041
Barros Silva R, et al. Caffeic Acid Phenethyl Ester Protects Against the Dopaminergic Neuronal Loss Induced By 6-hydroxydopamine in Rats. Neuroscience. 2013 Mar 13;233:86-94. PubMed PMID: 23291456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats. AU - Barros Silva,R, AU - Santos,N A G, AU - Martins,N M, AU - Ferreira,D A S, AU - Barbosa,F,Jr AU - Oliveira Souza,V C, AU - Kinoshita,A, AU - Baffa,O, AU - Del-Bel,E, AU - Santos,A C, Y1 - 2013/01/03/ PY - 2012/09/10/received PY - 2012/12/20/revised PY - 2012/12/22/accepted PY - 2013/1/8/entrez PY - 2013/1/8/pubmed PY - 2013/9/24/medline SP - 86 EP - 94 JF - Neuroscience JO - Neuroscience VL - 233 N2 - Caffeic acid phenethyl ester (CAPE) is a botanical compound abundant in honeybees' propolis. It has anti-inflammatory, antiviral, antioxidant, immunomodulatory and antitumor properties. Its beneficial effects against neurodegenerative diseases, including Parkinson's disease, have also been suggested and some mechanisms have been proposed. Mitochondrial damage and oxidative stress are critical events in neurodegeneration. Release of cytochrome c from mitochondria to cytosol and the downstream activation of caspase-3 have been suggested as targets of the protective mechanism of CAPE. Most of the studies addressing the protective effect of CAPE have been performed in cell culture. This is the first study to demonstrate the protective effect of CAPE against the dopaminergic neuronal loss induced by 6-hydroxydopamine (6-OHDA) in rats. It also demonstrates, for the first time, the inhibitory effect of CAPE on mitochondrial permeability transition (MPT), a mediator of neuronal death that triggers cytochrome c release and caspase-3 activation. Scavenging of reactive oxygen species (ROS) and metal chelation was demonstrated in the brain-affected areas of the rats treated with 6-OHDA and CAPE. Additionally, we demonstrated that CAPE does not affect brain mitochondrial function. Based on these findings and on its ability to cross the blood-brain barrier, CAPE is a promising compound to treat Parkinson's and other neurodegenerative diseases. SN - 1873-7544 UR - https://www.unboundmedicine.com/medline/citation/23291456/Caffeic_acid_phenethyl_ester_protects_against_the_dopaminergic_neuronal_loss_induced_by_6_hydroxydopamine_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(12)01236-5 DB - PRIME DP - Unbound Medicine ER -