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The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms.
Cancer Manag Res. 2012; 4:431-45.CM

Abstract

Cancer is the leading cause of death in the USA, and the incidence of cancer increases dramatically with age. Beta-adrenergic blockers appear to have a beneficial clinical effect in cancer patients. In this paper, we review the evidence of an association between β-adrenergic blockade and cancer. Genetic studies have provided the opportunity to determine which proteins link β-adrenergic blockade to cancer pathology. In particular, this link involves the major histocompatibility complex class II molecules, the renin-angiotensin system, transcription factor nuclear factor-kappa-light-chain-enhancer of activated B cells, poly(ADP-ribose) polymerase-1, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate oxidase. Beta-adrenergic blockers also exert anticancer effects through non-genomic factors, including matrix metalloproteinase, mitogen-activated protein kinase pathways, prostaglandins, cyclooxygenase-2, oxidative stress, and nitric oxide synthase. In conclusion, β-adrenergic blockade may play a beneficial role in cancer treatment. Additional investigations that examine β-adrenergic blockers as cancer therapeutics are required to further elucidate this role.

Authors+Show Affiliations

Vietnamese American Medical Research Foundation, Westminster, California, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23293538

Citation

Quốc Lu'o'ng, Khanh Vinh, and Lan Thi Hoàng Nguyễn. "The Roles of Beta-adrenergic Receptors in Tumorigenesis and the Possible Use of Beta-adrenergic Blockers for Cancer Treatment: Possible Genetic and Cell-signaling Mechanisms." Cancer Management and Research, vol. 4, 2012, pp. 431-45.
Quốc Lu'o'ng KV, Nguyễn LT. The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms. Cancer Manag Res. 2012;4:431-45.
Quốc Lu'o'ng, K. V., & Nguyễn, L. T. (2012). The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms. Cancer Management and Research, 4, 431-45. https://doi.org/10.2147/CMAR.S39153
Quốc Lu'o'ng KV, Nguyễn LT. The Roles of Beta-adrenergic Receptors in Tumorigenesis and the Possible Use of Beta-adrenergic Blockers for Cancer Treatment: Possible Genetic and Cell-signaling Mechanisms. Cancer Manag Res. 2012;4:431-45. PubMed PMID: 23293538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The roles of beta-adrenergic receptors in tumorigenesis and the possible use of beta-adrenergic blockers for cancer treatment: possible genetic and cell-signaling mechanisms. AU - Quốc Lu'o'ng,Khanh Vinh, AU - Nguyễn,Lan Thi Hoàng, Y1 - 2012/12/18/ PY - 2013/1/8/entrez PY - 2013/1/8/pubmed PY - 2013/1/8/medline KW - neoplasm KW - non-genomic factor KW - β-adrenergic antagonism KW - β-adrenergic blocker SP - 431 EP - 45 JF - Cancer management and research JO - Cancer Manag Res VL - 4 N2 - Cancer is the leading cause of death in the USA, and the incidence of cancer increases dramatically with age. Beta-adrenergic blockers appear to have a beneficial clinical effect in cancer patients. In this paper, we review the evidence of an association between β-adrenergic blockade and cancer. Genetic studies have provided the opportunity to determine which proteins link β-adrenergic blockade to cancer pathology. In particular, this link involves the major histocompatibility complex class II molecules, the renin-angiotensin system, transcription factor nuclear factor-kappa-light-chain-enhancer of activated B cells, poly(ADP-ribose) polymerase-1, vascular endothelial growth factor, and the reduced form of nicotinamide adenine dinucleotide phosphate oxidase. Beta-adrenergic blockers also exert anticancer effects through non-genomic factors, including matrix metalloproteinase, mitogen-activated protein kinase pathways, prostaglandins, cyclooxygenase-2, oxidative stress, and nitric oxide synthase. In conclusion, β-adrenergic blockade may play a beneficial role in cancer treatment. Additional investigations that examine β-adrenergic blockers as cancer therapeutics are required to further elucidate this role. SN - 1179-1322 UR - https://www.unboundmedicine.com/medline/citation/23293538/The_roles_of_beta_adrenergic_receptors_in_tumorigenesis_and_the_possible_use_of_beta_adrenergic_blockers_for_cancer_treatment:_possible_genetic_and_cell_signaling_mechanisms_ L2 - https://dx.doi.org/10.2147/CMAR.S39153 DB - PRIME DP - Unbound Medicine ER -
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