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Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature.
Oral Dis. 2013 Nov; 19(8):738-46.OD

Abstract

OBJECTIVE

To present a retrospective analysis of multicentre case series of oral syphilis and a review of relevant literature.

SUBJECTS AND METHODS

A PUBMED search was carried out from 1950 to 2011. Clinical records of patients with exclusive/prevalent oral manifestations of syphilis were collected and examined in three independent hospitals.

RESULTS

Of 23 reports describing 34 patients were detected through the review (35% primary, 56% secondary, and 9% tertiary disease), describing unspecific ulcers (59%), mucosal patches (23%), keratosis (6%), pseudomembranes (3%), and gumma (9%). Multicentre case series revealed 12 patients with oral syphilis, of which 17%, 58%, and 25% with, respectively, primary, secondary, and tertiary lesions. Clinically, patients showed white patches (17%), blistering mucositis (8%), chronic unspecific ulcers with/without skin lesions (50%), gumma (17%), and necrosis of the dorsum of the tongue (8%). Oral bullae and tongue necrosis are never described in the current review.

CONCLUSIONS

Diagnosis of syphilis remains a challenge because of the multiform and polymorphous clinical pattern at onset and its ability to imitate different diseases. It is mandatory to include syphilis in the differential diagnosis of unusual oral lesions. Diagnosis of oral lesions of syphilis is often difficult, and biopsy is required in controversial cases.

Authors+Show Affiliations

Department of Odontostomatological and Maxillo Facial Sciences, Oral Medicine Unit, Federico II University of Naples, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Multicenter Study
Review

Language

eng

PubMed ID

23294141

Citation

Leuci, S, et al. "Oral Syphilis: a Retrospective Analysis of 12 Cases and a Review of the Literature." Oral Diseases, vol. 19, no. 8, 2013, pp. 738-46.
Leuci S, Martina S, Adamo D, et al. Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature. Oral Dis. 2013;19(8):738-46.
Leuci, S., Martina, S., Adamo, D., Ruoppo, E., Santarelli, A., Sorrentino, R., Favia, G., & Mignogna, M. (2013). Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature. Oral Diseases, 19(8), 738-46. https://doi.org/10.1111/odi.12058
Leuci S, et al. Oral Syphilis: a Retrospective Analysis of 12 Cases and a Review of the Literature. Oral Dis. 2013;19(8):738-46. PubMed PMID: 23294141.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral Syphilis: a retrospective analysis of 12 cases and a review of the literature. AU - Leuci,S, AU - Martina,S, AU - Adamo,D, AU - Ruoppo,E, AU - Santarelli,A, AU - Sorrentino,R, AU - Favia,G, AU - Mignogna,Md, Y1 - 2013/01/07/ PY - 2012/10/04/received PY - 2012/11/28/revised PY - 2012/12/01/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2015/9/24/medline KW - oral mucosa KW - syphilis KW - treponema pallidum SP - 738 EP - 46 JF - Oral diseases JO - Oral Dis VL - 19 IS - 8 N2 - OBJECTIVE: To present a retrospective analysis of multicentre case series of oral syphilis and a review of relevant literature. SUBJECTS AND METHODS: A PUBMED search was carried out from 1950 to 2011. Clinical records of patients with exclusive/prevalent oral manifestations of syphilis were collected and examined in three independent hospitals. RESULTS: Of 23 reports describing 34 patients were detected through the review (35% primary, 56% secondary, and 9% tertiary disease), describing unspecific ulcers (59%), mucosal patches (23%), keratosis (6%), pseudomembranes (3%), and gumma (9%). Multicentre case series revealed 12 patients with oral syphilis, of which 17%, 58%, and 25% with, respectively, primary, secondary, and tertiary lesions. Clinically, patients showed white patches (17%), blistering mucositis (8%), chronic unspecific ulcers with/without skin lesions (50%), gumma (17%), and necrosis of the dorsum of the tongue (8%). Oral bullae and tongue necrosis are never described in the current review. CONCLUSIONS: Diagnosis of syphilis remains a challenge because of the multiform and polymorphous clinical pattern at onset and its ability to imitate different diseases. It is mandatory to include syphilis in the differential diagnosis of unusual oral lesions. Diagnosis of oral lesions of syphilis is often difficult, and biopsy is required in controversial cases. SN - 1601-0825 UR - https://www.unboundmedicine.com/medline/citation/23294141/Oral_Syphilis:_a_retrospective_analysis_of_12_cases_and_a_review_of_the_literature_ L2 - https://doi.org/10.1111/odi.12058 DB - PRIME DP - Unbound Medicine ER -