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Total and specific fruit and vegetable consumption and risk of stroke: a prospective study.

Abstract

BACKGROUND

Fruit and vegetables is a heterogeneous food group with different content of dietary fiber, vitamins, minerals, carotenoids, and bioactive phytochemicals. Our objective was to examine the relation between specific consumption of fruit and vegetable subgroups and stroke risk in a cohort of Swedish women and men.

METHODS AND RESULTS

We prospectively followed 74,961 participants (34,670 women and 40,291 men) who had completed a food frequency questionnaire in the autumn of 1997 and were free from stroke, coronary heart disease, and cancer at baseline. Diagnoses of stroke in the cohort during follow-up were ascertained from the Swedish Hospital Discharge Registry. A total of 4089 stroke cases, including 3159 cerebral infarctions, 435 intracerebral hemorrhages, 148 subarachnoid hemorrhages, and 347 unspecified strokes, were ascertained during 10.2 years of follow-up. The multivariable relative risk (RR) of total stroke for the highest vs. lowest category of total fruit and vegetable consumption was 0.87 (95% confidence interval [CI] 0.78-0.97; P for trend = 0.01). The association was confined to individuals without hypertension (corresponding RR, 0.81; 95% CI, 0.71-0.93; P for trend = 0.01). Among individual fruits and vegetable subgroups, inverse associations with total stroke were observed for apples/pears (RR, 0.89; 95% CI, 0.80-0.98; P for trend = 0.02) and green leafy vegetables (RR, 0.92; 95% CI, 0.81-1.04; P for trend = 0.03).

CONCLUSION

This study shows an inverse association of fruit and vegetable consumption with stroke risk. Particularly consumption of apples and pears and green leafy vegetables was inversely associated with stroke.

Links

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institutet, Box 210, SE-17177 Stockholm, Sweden. susanna.larsson@ki.se

    ,

    Source

    Atherosclerosis 227:1 2013 Mar pg 147-52

    MeSH

    Aged
    Aged, 80 and over
    Cerebral Hemorrhage
    Cerebral Infarction
    Diet
    Dietary Fiber
    Female
    Fruit
    Humans
    Male
    Malus
    Middle Aged
    Prospective Studies
    Pyrus
    Risk
    Risk Factors
    Stroke
    Subarachnoid Hemorrhage
    Sweden
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23294925

    Citation

    Larsson, Susanna C., et al. "Total and Specific Fruit and Vegetable Consumption and Risk of Stroke: a Prospective Study." Atherosclerosis, vol. 227, no. 1, 2013, pp. 147-52.
    Larsson SC, Virtamo J, Wolk A. Total and specific fruit and vegetable consumption and risk of stroke: a prospective study. Atherosclerosis. 2013;227(1):147-52.
    Larsson, S. C., Virtamo, J., & Wolk, A. (2013). Total and specific fruit and vegetable consumption and risk of stroke: a prospective study. Atherosclerosis, 227(1), pp. 147-52. doi:10.1016/j.atherosclerosis.2012.12.022.
    Larsson SC, Virtamo J, Wolk A. Total and Specific Fruit and Vegetable Consumption and Risk of Stroke: a Prospective Study. Atherosclerosis. 2013;227(1):147-52. PubMed PMID: 23294925.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Total and specific fruit and vegetable consumption and risk of stroke: a prospective study. AU - Larsson,Susanna C, AU - Virtamo,Jarmo, AU - Wolk,Alicja, Y1 - 2012/12/28/ PY - 2012/08/21/received PY - 2012/11/15/revised PY - 2012/12/04/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/8/2/medline SP - 147 EP - 52 JF - Atherosclerosis JO - Atherosclerosis VL - 227 IS - 1 N2 - BACKGROUND: Fruit and vegetables is a heterogeneous food group with different content of dietary fiber, vitamins, minerals, carotenoids, and bioactive phytochemicals. Our objective was to examine the relation between specific consumption of fruit and vegetable subgroups and stroke risk in a cohort of Swedish women and men. METHODS AND RESULTS: We prospectively followed 74,961 participants (34,670 women and 40,291 men) who had completed a food frequency questionnaire in the autumn of 1997 and were free from stroke, coronary heart disease, and cancer at baseline. Diagnoses of stroke in the cohort during follow-up were ascertained from the Swedish Hospital Discharge Registry. A total of 4089 stroke cases, including 3159 cerebral infarctions, 435 intracerebral hemorrhages, 148 subarachnoid hemorrhages, and 347 unspecified strokes, were ascertained during 10.2 years of follow-up. The multivariable relative risk (RR) of total stroke for the highest vs. lowest category of total fruit and vegetable consumption was 0.87 (95% confidence interval [CI] 0.78-0.97; P for trend = 0.01). The association was confined to individuals without hypertension (corresponding RR, 0.81; 95% CI, 0.71-0.93; P for trend = 0.01). Among individual fruits and vegetable subgroups, inverse associations with total stroke were observed for apples/pears (RR, 0.89; 95% CI, 0.80-0.98; P for trend = 0.02) and green leafy vegetables (RR, 0.92; 95% CI, 0.81-1.04; P for trend = 0.03). CONCLUSION: This study shows an inverse association of fruit and vegetable consumption with stroke risk. Particularly consumption of apples and pears and green leafy vegetables was inversely associated with stroke. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/23294925/Total_and_specific_fruit_and_vegetable_consumption_and_risk_of_stroke:_a_prospective_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(12)00883-0 DB - PRIME DP - Unbound Medicine ER -