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Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery.
Chirurgia (Bucur). 2012 Nov-Dec; 107(6):772-9.C

Abstract

BACKGROUND

Liver biopsy, an invasive method, is the gold standard for differentiate nonalcoholic steatohepatitis (NASH) from other stages of fatty liver disease. A noninvasive test to diagnose NASH and disease severity before surgery and also for monitoring disease status after bariatric surgery (BS) will be an important medical challenge.

AIM

To create a noninvasive biomarkers model for the diagnosis of NASH in overweight, obese and morbidly obese patients (MOP).

PATIENTS AND METHODS

Sixty patients (mean BMI= 47.81kg/m2) were admitted after exclusion of other causes of liver disease. Liver biopsies were obtained at the time of the bariatric surgery or by percutaneous liver biopsy and graded using Kleiner score. Continuous variables were compared using Wilcoxon rank sum test and for prediction of NASH we used logistic regression.

RESULTS

Logistic regression analysis showed that BMI, ALT, AST, alkaline phosphatase (ALP), HOMA-R, hs-CRP, M30, M65, leptine and adiponectine levels remained independent predictors for NASH (p less than 0.02). Using AUC analysis, we established the following cutoff levels being indicative of NASH: BMI ė 47 kg/m2, ALT ė 32 IU/mL, AST ė 25 IU/mL, ALP ė 85 IU/mL, HOMA-IR ė 4, M65 ė 389 U/L. Adiponectine less than 13.5 mg/L. A NASH-score, calculated as the sum of these 7 parameters, at a cutoff level of 4 points, can accurately predict NASH (sensitivity of 90%, specificity of 93.94% and AUC of 0.9576).

CONCLUSIONS

We propose a noninvasive model for NASH diagnosis in MOP that should be validated prospectively. Using this noninvasive score, NASH would be predicted without the risks of liver biopsy.

Authors+Show Affiliations

Department of Gastroenterology, Fundeni Clinical Institute, Bucharest, Romania. iulianapirvilescu@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23294957

Citation

Pirvulescu, I, et al. "Noninvasive Clinical Model for the Diagnosis of Nonalcoholic Steatohepatitis in Overweight and Morbidly Obese Patients Undergoing Bariatric Surgery." Chirurgia (Bucharest, Romania : 1990), vol. 107, no. 6, 2012, pp. 772-9.
Pirvulescu I, Gheorghe L, Csiki I, et al. Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. Chirurgia (Bucur). 2012;107(6):772-9.
Pirvulescu, I., Gheorghe, L., Csiki, I., Becheanu, G., Dumbravă, M., Fica, S., Martin, S., Sarbu, A., Gheorghe, C., Diculescu, M., & Copăescu, C. (2012). Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. Chirurgia (Bucharest, Romania : 1990), 107(6), 772-9.
Pirvulescu I, et al. Noninvasive Clinical Model for the Diagnosis of Nonalcoholic Steatohepatitis in Overweight and Morbidly Obese Patients Undergoing Bariatric Surgery. Chirurgia (Bucur). 2012 Nov-Dec;107(6):772-9. PubMed PMID: 23294957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Noninvasive clinical model for the diagnosis of nonalcoholic steatohepatitis in overweight and morbidly obese patients undergoing bariatric surgery. AU - Pirvulescu,I, AU - Gheorghe,L, AU - Csiki,I, AU - Becheanu,G, AU - Dumbravă,M, AU - Fica,S, AU - Martin,S, AU - Sarbu,A, AU - Gheorghe,C, AU - Diculescu,M, AU - Copăescu,C, PY - 2012/12/01/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/5/18/medline SP - 772 EP - 9 JF - Chirurgia (Bucharest, Romania : 1990) JO - Chirurgia (Bucur) VL - 107 IS - 6 N2 - BACKGROUND: Liver biopsy, an invasive method, is the gold standard for differentiate nonalcoholic steatohepatitis (NASH) from other stages of fatty liver disease. A noninvasive test to diagnose NASH and disease severity before surgery and also for monitoring disease status after bariatric surgery (BS) will be an important medical challenge. AIM: To create a noninvasive biomarkers model for the diagnosis of NASH in overweight, obese and morbidly obese patients (MOP). PATIENTS AND METHODS: Sixty patients (mean BMI= 47.81kg/m2) were admitted after exclusion of other causes of liver disease. Liver biopsies were obtained at the time of the bariatric surgery or by percutaneous liver biopsy and graded using Kleiner score. Continuous variables were compared using Wilcoxon rank sum test and for prediction of NASH we used logistic regression. RESULTS: Logistic regression analysis showed that BMI, ALT, AST, alkaline phosphatase (ALP), HOMA-R, hs-CRP, M30, M65, leptine and adiponectine levels remained independent predictors for NASH (p less than 0.02). Using AUC analysis, we established the following cutoff levels being indicative of NASH: BMI ė 47 kg/m2, ALT ė 32 IU/mL, AST ė 25 IU/mL, ALP ė 85 IU/mL, HOMA-IR ė 4, M65 ė 389 U/L. Adiponectine less than 13.5 mg/L. A NASH-score, calculated as the sum of these 7 parameters, at a cutoff level of 4 points, can accurately predict NASH (sensitivity of 90%, specificity of 93.94% and AUC of 0.9576). CONCLUSIONS: We propose a noninvasive model for NASH diagnosis in MOP that should be validated prospectively. Using this noninvasive score, NASH would be predicted without the risks of liver biopsy. SN - 1221-9118 UR - https://www.unboundmedicine.com/medline/citation/23294957/Noninvasive_clinical_model_for_the_diagnosis_of_nonalcoholic_steatohepatitis_in_overweight_and_morbidly_obese_patients_undergoing_bariatric_surgery_ L2 - http://revistachirurgia.ro/pdfs/2012-6-772.pdf DB - PRIME DP - Unbound Medicine ER -