Tags

Type your tag names separated by a space and hit enter

The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides.
Toxicology 2013; 307:17-23T

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. Single risk factors are likely to exert relatively minor effects, whereas their interaction may prove to be sufficient to cause PD. In the present review we summarize current knowledge from human genetic association studies regarding the interaction between gene polymorphisms and pesticide exposure in the risk of PD. A number of genetic association studies have investigated joint effects between genes and pesticides on PD risk. They have provided some evidence that genetic susceptibility either in metabolism, elimination and transport of pesticides or in the extent of mitochondrial dysfunction, oxidative stress and neuronal loss may predispose individuals to PD if they have been exposed to pesticides. These findings confirm the importance of considering pesticide-gene interactions in future studies in order to gain a better understanding of the pathogenic mechanisms of PD.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, University of Thessaly, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23295711

Citation

Dardiotis, Efthimios, et al. "The Interplay Between Environmental and Genetic Factors in Parkinson's Disease Susceptibility: the Evidence for Pesticides." Toxicology, vol. 307, 2013, pp. 17-23.
Dardiotis E, Xiromerisiou G, Hadjichristodoulou C, et al. The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides. Toxicology. 2013;307:17-23.
Dardiotis, E., Xiromerisiou, G., Hadjichristodoulou, C., Tsatsakis, A. M., Wilks, M. F., & Hadjigeorgiou, G. M. (2013). The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides. Toxicology, 307, pp. 17-23. doi:10.1016/j.tox.2012.12.016.
Dardiotis E, et al. The Interplay Between Environmental and Genetic Factors in Parkinson's Disease Susceptibility: the Evidence for Pesticides. Toxicology. 2013 May 10;307:17-23. PubMed PMID: 23295711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides. AU - Dardiotis,Efthimios, AU - Xiromerisiou,Georgia, AU - Hadjichristodoulou,Christos, AU - Tsatsakis,Aristidis M, AU - Wilks,Martin F, AU - Hadjigeorgiou,Georgios M, Y1 - 2013/01/04/ PY - 2012/11/22/received PY - 2012/12/23/revised PY - 2012/12/25/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/7/16/medline SP - 17 EP - 23 JF - Toxicology JO - Toxicology VL - 307 N2 - Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. Single risk factors are likely to exert relatively minor effects, whereas their interaction may prove to be sufficient to cause PD. In the present review we summarize current knowledge from human genetic association studies regarding the interaction between gene polymorphisms and pesticide exposure in the risk of PD. A number of genetic association studies have investigated joint effects between genes and pesticides on PD risk. They have provided some evidence that genetic susceptibility either in metabolism, elimination and transport of pesticides or in the extent of mitochondrial dysfunction, oxidative stress and neuronal loss may predispose individuals to PD if they have been exposed to pesticides. These findings confirm the importance of considering pesticide-gene interactions in future studies in order to gain a better understanding of the pathogenic mechanisms of PD. SN - 1879-3185 UR - https://www.unboundmedicine.com/medline/citation/23295711/The_interplay_between_environmental_and_genetic_factors_in_Parkinson's_disease_susceptibility:_the_evidence_for_pesticides_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(12)00444-1 DB - PRIME DP - Unbound Medicine ER -