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In vitro antimicrobial assessment of Cuban propolis extracts.
Mem Inst Oswaldo Cruz 2012; 107(8):978-84MI

Abstract

Propolis is a resinous mixture of different plant exudates collected by honeybees. Currently, propolis is widely used as a food supplement and in folk medicine. We have evaluated 20 Cuban propolis extracts of different chemical types, brown (BCP), red and yellow (YCP), with respect to their in vitro antibacterial, antifungal and antiprotozoal properties. The extracts inhibited the growth of Staphylococcus aureus and Trichophyton rubrum at low µg/mL concentrations, whereas they were not active against Escherichia coli and Candida albicans. The major activity of the extracts was found against the protozoa Leishmania, Trypanosoma and Plasmodium, although cytotoxicity against MRC-5 cells was also observed. The BCP-3, YCP-39 and YCP-60 extracts showed the highest activity against P. falciparum, with 50% of microbial growth (IC₅₀) values of 0.2 µg/mL. A positive correlation between the biological activity and the chemical composition was observed for YCP extracts. The most promising antimicrobial activity corresponds to YCP subtype B, which contains acetyl triterpenes as the main constituents. The present in vitro study highlights the potential of propolis against protozoa, but further research is needed to increase selectivity towards the parasite. The observed chemical composition-activity relationship of propolis can contribute to the identification of the active principles and standardisation of this bee product.

Authors+Show Affiliations

Department of Parasitology, Institute of Tropical Medicine Pedro Kouri, Havana, Cuba.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23295746

Citation

Monzote, Lianet, et al. "In Vitro Antimicrobial Assessment of Cuban Propolis Extracts." Memorias Do Instituto Oswaldo Cruz, vol. 107, no. 8, 2012, pp. 978-84.
Monzote L, Cuesta-Rubio O, Campo Fernandez M, et al. In vitro antimicrobial assessment of Cuban propolis extracts. Mem Inst Oswaldo Cruz. 2012;107(8):978-84.
Monzote, L., Cuesta-Rubio, O., Campo Fernandez, M., Márquez Hernandez, I., Fraga, J., Pérez, K., ... Cos, P. (2012). In vitro antimicrobial assessment of Cuban propolis extracts. Memorias Do Instituto Oswaldo Cruz, 107(8), pp. 978-84.
Monzote L, et al. In Vitro Antimicrobial Assessment of Cuban Propolis Extracts. Mem Inst Oswaldo Cruz. 2012;107(8):978-84. PubMed PMID: 23295746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro antimicrobial assessment of Cuban propolis extracts. AU - Monzote,Lianet, AU - Cuesta-Rubio,Osmany, AU - Campo Fernandez,Mercedes, AU - Márquez Hernandez,Ingrid, AU - Fraga,Jorge, AU - Pérez,Kleich, AU - Kerstens,Monique, AU - Maes,Louis, AU - Cos,Paul, PY - 2012/02/01/received PY - 2012/07/18/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/6/26/medline SP - 978 EP - 84 JF - Memorias do Instituto Oswaldo Cruz JO - Mem. Inst. Oswaldo Cruz VL - 107 IS - 8 N2 - Propolis is a resinous mixture of different plant exudates collected by honeybees. Currently, propolis is widely used as a food supplement and in folk medicine. We have evaluated 20 Cuban propolis extracts of different chemical types, brown (BCP), red and yellow (YCP), with respect to their in vitro antibacterial, antifungal and antiprotozoal properties. The extracts inhibited the growth of Staphylococcus aureus and Trichophyton rubrum at low µg/mL concentrations, whereas they were not active against Escherichia coli and Candida albicans. The major activity of the extracts was found against the protozoa Leishmania, Trypanosoma and Plasmodium, although cytotoxicity against MRC-5 cells was also observed. The BCP-3, YCP-39 and YCP-60 extracts showed the highest activity against P. falciparum, with 50% of microbial growth (IC₅₀) values of 0.2 µg/mL. A positive correlation between the biological activity and the chemical composition was observed for YCP extracts. The most promising antimicrobial activity corresponds to YCP subtype B, which contains acetyl triterpenes as the main constituents. The present in vitro study highlights the potential of propolis against protozoa, but further research is needed to increase selectivity towards the parasite. The observed chemical composition-activity relationship of propolis can contribute to the identification of the active principles and standardisation of this bee product. SN - 1678-8060 UR - https://www.unboundmedicine.com/medline/citation/23295746/In_vitro_antimicrobial_assessment_of_Cuban_propolis_extracts_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000800003&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -