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Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden.
Neurosci Lett. 2013 Mar 01; 536:74-9.NL

Abstract

Epidemiological studies suggest that cerebral ischemia may contribute to the onset and progression of Alzheimer's disease (AD). However, the mechanism by which ischemic events trigger the onset and progression of AD is poorly understood. Acetylcholine (ACh) is one of the key factors in memory, and cholinergic disturbance is a primary feature of AD. To clarify whether cholinergic disturbance is implicated in the exacerbation of AD symptoms by cerebral ischemia, memory impairment and hippocampal ACh release were examined in young (4-6 month-old) Tg2576 (Tg) mice, an AD transgenic mouse model, and in age-matched control mice with or without transient cerebral ischemia (bilateral common carotid artery occlusion: 2VO). 2VO induced memory impairment and decreased high-K(+)-evoked ACh release in Tg mice, but not in control mice. There were no differences in memory and ACh release between sham-operated control and Tg mice. Increases in β-amyloid (Aβ) 40 and Aβ42 were also observed in 2VO-operated Tg mice compared with sham-operated Tg mice, but no evident amyloid plaques or neuronal loss were found in the hippocampus of these mice. These results suggest that the memory of Tg mice is affected by 2VO, and the memory impairment may be due to cholinergic dysfunction induced by Aβ. Our findings support the idea that cerebral hypoperfusion could be a risk factor for AD.

Authors+Show Affiliations

Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. twatanabe@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23295908

Citation

Watanabe, Takuya, et al. "Facilitation of Memory Impairment and Cholinergic Disturbance in a Mouse Model of Alzheimer's Disease By Mild Ischemic Burden." Neuroscience Letters, vol. 536, 2013, pp. 74-9.
Watanabe T, Takasaki K, Yamagata N, et al. Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden. Neurosci Lett. 2013;536:74-9.
Watanabe, T., Takasaki, K., Yamagata, N., Fujiwara, M., & Iwasaki, K. (2013). Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden. Neuroscience Letters, 536, 74-9. https://doi.org/10.1016/j.neulet.2012.12.041
Watanabe T, et al. Facilitation of Memory Impairment and Cholinergic Disturbance in a Mouse Model of Alzheimer's Disease By Mild Ischemic Burden. Neurosci Lett. 2013 Mar 1;536:74-9. PubMed PMID: 23295908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Facilitation of memory impairment and cholinergic disturbance in a mouse model of Alzheimer's disease by mild ischemic burden. AU - Watanabe,Takuya, AU - Takasaki,Kotaro, AU - Yamagata,Norito, AU - Fujiwara,Michihiro, AU - Iwasaki,Katsunori, Y1 - 2013/01/04/ PY - 2012/12/07/received PY - 2012/12/27/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/7/3/medline SP - 74 EP - 9 JF - Neuroscience letters JO - Neurosci Lett VL - 536 N2 - Epidemiological studies suggest that cerebral ischemia may contribute to the onset and progression of Alzheimer's disease (AD). However, the mechanism by which ischemic events trigger the onset and progression of AD is poorly understood. Acetylcholine (ACh) is one of the key factors in memory, and cholinergic disturbance is a primary feature of AD. To clarify whether cholinergic disturbance is implicated in the exacerbation of AD symptoms by cerebral ischemia, memory impairment and hippocampal ACh release were examined in young (4-6 month-old) Tg2576 (Tg) mice, an AD transgenic mouse model, and in age-matched control mice with or without transient cerebral ischemia (bilateral common carotid artery occlusion: 2VO). 2VO induced memory impairment and decreased high-K(+)-evoked ACh release in Tg mice, but not in control mice. There were no differences in memory and ACh release between sham-operated control and Tg mice. Increases in β-amyloid (Aβ) 40 and Aβ42 were also observed in 2VO-operated Tg mice compared with sham-operated Tg mice, but no evident amyloid plaques or neuronal loss were found in the hippocampus of these mice. These results suggest that the memory of Tg mice is affected by 2VO, and the memory impairment may be due to cholinergic dysfunction induced by Aβ. Our findings support the idea that cerebral hypoperfusion could be a risk factor for AD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/23295908/Facilitation_of_memory_impairment_and_cholinergic_disturbance_in_a_mouse_model_of_Alzheimer's_disease_by_mild_ischemic_burden_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(12)01608-4 DB - PRIME DP - Unbound Medicine ER -