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Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients?

Abstract

AIMS

Dyslipidemia and oxidative stress are commonly present in patients during maintenance dialysis treatment. However, the significance of oxidized LDL (oxLDL) as a marker of oxidative stress in uremia is still unresolved. The aim of this study was to establish the role of oxLDL and oxLDL/LDL ratio as markers of lipoprotein abnormalities and oxidative stress in the dialyzed patients.

MAIN METHODS

Plasma oxLDL level was measured by ELISA, and oxLDL/LDL ratio was calculated in 106 dialyzed patients and 20 controls. The linkages between oxLDL, oxLDL/LDL ratio and lipid profile and oxidative stress markers malondialdehyde (MDA) and Cu/Zn superoxide dismutase (Cu/Zn SOD) levels were also analyzed.

KEY FINDINGS

OxLDL levels and oxLDL/LDL ratio were similar in hemodialyzed patients and controls, whereas these parameters were lower in peritoneally dialyzed patients when compared to healthy individuals. In contrast, both MDA and Cu/Zn SOD levels were significantly higher in uremics than in controls. oxLDL and oxLDL/LDL ratio positively correlated with lipid profile (except of HDL), whereas there were no positive associations between these parameters and both MDA and Cu/Zn SOD. Multiple regression analysis confirmed that increased oxLDL/HDL and TC/HDL ratios and total cholesterol levels are the parameters which independently predicted oxLDL in dialyzed patients. In the case of oxLDL/LDL ratio, the independent variables were oxLDL/HDL ratio, total cholesterol and HDL levels.

SIGNIFICANCE

oxLDL levels and oxLDL/LDL ratio seem to be the markers of lipoprotein abnormalities rather than the markers of oxidative stress in the population of dialyzed patients.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland.

    ,

    Source

    Life sciences 92:4-5 2013 Mar 12 pg 253-8

    MeSH

    Analysis of Variance
    Biomarkers
    C-Reactive Protein
    Cross-Sectional Studies
    Data Interpretation, Statistical
    Dyslipidemias
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Lipoproteins, LDL
    Male
    Malondialdehyde
    Middle Aged
    Oxidation-Reduction
    Oxidative Stress
    Regression Analysis
    Renal Dialysis
    Superoxide Dismutase
    Uremia

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23295961

    Citation

    Pawlak, Krystyna, et al. "Oxidized Low-density Lipoprotein (oxLDL) Plasma Levels and oxLDL to LDL Ratio - Are They Real Oxidative Stress Markers in Dialyzed Patients?" Life Sciences, vol. 92, no. 4-5, 2013, pp. 253-8.
    Pawlak K, Mysliwiec M, Pawlak D. Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? Life Sci. 2013;92(4-5):253-8.
    Pawlak, K., Mysliwiec, M., & Pawlak, D. (2013). Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? Life Sciences, 92(4-5), pp. 253-8. doi:10.1016/j.lfs.2012.12.002.
    Pawlak K, Mysliwiec M, Pawlak D. Oxidized Low-density Lipoprotein (oxLDL) Plasma Levels and oxLDL to LDL Ratio - Are They Real Oxidative Stress Markers in Dialyzed Patients. Life Sci. 2013 Mar 12;92(4-5):253-8. PubMed PMID: 23295961.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? AU - Pawlak,Krystyna, AU - Mysliwiec,Michal, AU - Pawlak,Dariusz, Y1 - 2013/01/04/ PY - 2012/03/09/received PY - 2012/11/14/revised PY - 2012/12/13/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/4/6/medline SP - 253 EP - 8 JF - Life sciences JO - Life Sci. VL - 92 IS - 4-5 N2 - AIMS: Dyslipidemia and oxidative stress are commonly present in patients during maintenance dialysis treatment. However, the significance of oxidized LDL (oxLDL) as a marker of oxidative stress in uremia is still unresolved. The aim of this study was to establish the role of oxLDL and oxLDL/LDL ratio as markers of lipoprotein abnormalities and oxidative stress in the dialyzed patients. MAIN METHODS: Plasma oxLDL level was measured by ELISA, and oxLDL/LDL ratio was calculated in 106 dialyzed patients and 20 controls. The linkages between oxLDL, oxLDL/LDL ratio and lipid profile and oxidative stress markers malondialdehyde (MDA) and Cu/Zn superoxide dismutase (Cu/Zn SOD) levels were also analyzed. KEY FINDINGS: OxLDL levels and oxLDL/LDL ratio were similar in hemodialyzed patients and controls, whereas these parameters were lower in peritoneally dialyzed patients when compared to healthy individuals. In contrast, both MDA and Cu/Zn SOD levels were significantly higher in uremics than in controls. oxLDL and oxLDL/LDL ratio positively correlated with lipid profile (except of HDL), whereas there were no positive associations between these parameters and both MDA and Cu/Zn SOD. Multiple regression analysis confirmed that increased oxLDL/HDL and TC/HDL ratios and total cholesterol levels are the parameters which independently predicted oxLDL in dialyzed patients. In the case of oxLDL/LDL ratio, the independent variables were oxLDL/HDL ratio, total cholesterol and HDL levels. SIGNIFICANCE: oxLDL levels and oxLDL/LDL ratio seem to be the markers of lipoprotein abnormalities rather than the markers of oxidative stress in the population of dialyzed patients. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/23295961/Oxidized_low_density_lipoprotein__oxLDL__plasma_levels_and_oxLDL_to_LDL_ratio___are_they_real_oxidative_stress_markers_in_dialyzed_patients L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(12)00738-2 DB - PRIME DP - Unbound Medicine ER -