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Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients?
Life Sci 2013; 92(4-5):253-8LS

Abstract

AIMS

Dyslipidemia and oxidative stress are commonly present in patients during maintenance dialysis treatment. However, the significance of oxidized LDL (oxLDL) as a marker of oxidative stress in uremia is still unresolved. The aim of this study was to establish the role of oxLDL and oxLDL/LDL ratio as markers of lipoprotein abnormalities and oxidative stress in the dialyzed patients.

MAIN METHODS

Plasma oxLDL level was measured by ELISA, and oxLDL/LDL ratio was calculated in 106 dialyzed patients and 20 controls. The linkages between oxLDL, oxLDL/LDL ratio and lipid profile and oxidative stress markers malondialdehyde (MDA) and Cu/Zn superoxide dismutase (Cu/Zn SOD) levels were also analyzed.

KEY FINDINGS

OxLDL levels and oxLDL/LDL ratio were similar in hemodialyzed patients and controls, whereas these parameters were lower in peritoneally dialyzed patients when compared to healthy individuals. In contrast, both MDA and Cu/Zn SOD levels were significantly higher in uremics than in controls. oxLDL and oxLDL/LDL ratio positively correlated with lipid profile (except of HDL), whereas there were no positive associations between these parameters and both MDA and Cu/Zn SOD. Multiple regression analysis confirmed that increased oxLDL/HDL and TC/HDL ratios and total cholesterol levels are the parameters which independently predicted oxLDL in dialyzed patients. In the case of oxLDL/LDL ratio, the independent variables were oxLDL/HDL ratio, total cholesterol and HDL levels.

SIGNIFICANCE

oxLDL levels and oxLDL/LDL ratio seem to be the markers of lipoprotein abnormalities rather than the markers of oxidative stress in the population of dialyzed patients.

Authors+Show Affiliations

Department of Monitored Pharmacotherapy, Medical University, Bialystok, Poland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23295961

Citation

Pawlak, Krystyna, et al. "Oxidized Low-density Lipoprotein (oxLDL) Plasma Levels and oxLDL to LDL Ratio - Are They Real Oxidative Stress Markers in Dialyzed Patients?" Life Sciences, vol. 92, no. 4-5, 2013, pp. 253-8.
Pawlak K, Mysliwiec M, Pawlak D. Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? Life Sci. 2013;92(4-5):253-8.
Pawlak, K., Mysliwiec, M., & Pawlak, D. (2013). Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? Life Sciences, 92(4-5), pp. 253-8. doi:10.1016/j.lfs.2012.12.002.
Pawlak K, Mysliwiec M, Pawlak D. Oxidized Low-density Lipoprotein (oxLDL) Plasma Levels and oxLDL to LDL Ratio - Are They Real Oxidative Stress Markers in Dialyzed Patients. Life Sci. 2013 Mar 12;92(4-5):253-8. PubMed PMID: 23295961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidized low-density lipoprotein (oxLDL) plasma levels and oxLDL to LDL ratio - are they real oxidative stress markers in dialyzed patients? AU - Pawlak,Krystyna, AU - Mysliwiec,Michal, AU - Pawlak,Dariusz, Y1 - 2013/01/04/ PY - 2012/03/09/received PY - 2012/11/14/revised PY - 2012/12/13/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/4/6/medline SP - 253 EP - 8 JF - Life sciences JO - Life Sci. VL - 92 IS - 4-5 N2 - AIMS: Dyslipidemia and oxidative stress are commonly present in patients during maintenance dialysis treatment. However, the significance of oxidized LDL (oxLDL) as a marker of oxidative stress in uremia is still unresolved. The aim of this study was to establish the role of oxLDL and oxLDL/LDL ratio as markers of lipoprotein abnormalities and oxidative stress in the dialyzed patients. MAIN METHODS: Plasma oxLDL level was measured by ELISA, and oxLDL/LDL ratio was calculated in 106 dialyzed patients and 20 controls. The linkages between oxLDL, oxLDL/LDL ratio and lipid profile and oxidative stress markers malondialdehyde (MDA) and Cu/Zn superoxide dismutase (Cu/Zn SOD) levels were also analyzed. KEY FINDINGS: OxLDL levels and oxLDL/LDL ratio were similar in hemodialyzed patients and controls, whereas these parameters were lower in peritoneally dialyzed patients when compared to healthy individuals. In contrast, both MDA and Cu/Zn SOD levels were significantly higher in uremics than in controls. oxLDL and oxLDL/LDL ratio positively correlated with lipid profile (except of HDL), whereas there were no positive associations between these parameters and both MDA and Cu/Zn SOD. Multiple regression analysis confirmed that increased oxLDL/HDL and TC/HDL ratios and total cholesterol levels are the parameters which independently predicted oxLDL in dialyzed patients. In the case of oxLDL/LDL ratio, the independent variables were oxLDL/HDL ratio, total cholesterol and HDL levels. SIGNIFICANCE: oxLDL levels and oxLDL/LDL ratio seem to be the markers of lipoprotein abnormalities rather than the markers of oxidative stress in the population of dialyzed patients. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/23295961/Oxidized_low_density_lipoprotein__oxLDL__plasma_levels_and_oxLDL_to_LDL_ratio___are_they_real_oxidative_stress_markers_in_dialyzed_patients L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(12)00738-2 DB - PRIME DP - Unbound Medicine ER -