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Variability in muscle adaptation to electrical stimulation.
Int J Sports Med. 2013 Jun; 34(6):544-53.IJ

Abstract

The aims were to investigate the plasticity of the myosin heavy chain (MHC) phenotype following neuromuscular electrical stimulation (NMES) and to assess the correlation between MHC isoform distribution and muscle fibre conduction velocity (MFCV).14 men were subjected to 24 sessions of quadriceps NMES. Needle biopsies were taken from the dominant vastus lateralis and neuromuscular tests were performed on the dominant thigh before and after training. NMES significantly increased the quadriceps maximal force by 14.4±19.7% (P=0.02), vastus lateralis thickness by 10.7±8.6% (P=0.01), vastus lateralis MFCV by 11.1±3.5% (P<0.001), vastus medialis MFCV by 8.4±1.8% (P<0.001). The whole spectrum of possible MHC isoform adaptations to training was observed: fast-to-slow transition (4 subjects), bi-directional transformation from MHC-1 and MHC-2X isoforms toward MHC-2A isoform (7 subjects), shift toward MHC-2X (2 subjects), no MHC distribution change (1 subject). No significant correlation was observed between MHC-2 relative content and vastus lateralis MFCV (pre-training: R2=0.04, P=0.46; post-training: R2=0.02, P=0.67). NMES elicited distinct adaptations in the MHC composition and increased force, muscle thickness, and MFCV. The MHC isoform distribution did not correlate with MFCV, thus implying that the proportion of different fibre types cannot be estimated from this electrophysiological variable.

Authors+Show Affiliations

Department of Internal Medicine, Division of Endocrinology, Diabetology and -Metabolism, Molinette Hospital, University of Turin, Turin, Italy. marco.minetto@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23296400

Citation

Minetto, M A., et al. "Variability in Muscle Adaptation to Electrical Stimulation." International Journal of Sports Medicine, vol. 34, no. 6, 2013, pp. 544-53.
Minetto MA, Botter A, Bottinelli O, et al. Variability in muscle adaptation to electrical stimulation. Int J Sports Med. 2013;34(6):544-53.
Minetto, M. A., Botter, A., Bottinelli, O., Miotti, D., Bottinelli, R., & D'Antona, G. (2013). Variability in muscle adaptation to electrical stimulation. International Journal of Sports Medicine, 34(6), 544-53. https://doi.org/10.1055/s-0032-1321799
Minetto MA, et al. Variability in Muscle Adaptation to Electrical Stimulation. Int J Sports Med. 2013;34(6):544-53. PubMed PMID: 23296400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability in muscle adaptation to electrical stimulation. AU - Minetto,M A, AU - Botter,A, AU - Bottinelli,O, AU - Miotti,D, AU - Bottinelli,R, AU - D'Antona,G, Y1 - 2013/01/07/ PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2014/1/15/medline SP - 544 EP - 53 JF - International journal of sports medicine JO - Int J Sports Med VL - 34 IS - 6 N2 - The aims were to investigate the plasticity of the myosin heavy chain (MHC) phenotype following neuromuscular electrical stimulation (NMES) and to assess the correlation between MHC isoform distribution and muscle fibre conduction velocity (MFCV).14 men were subjected to 24 sessions of quadriceps NMES. Needle biopsies were taken from the dominant vastus lateralis and neuromuscular tests were performed on the dominant thigh before and after training. NMES significantly increased the quadriceps maximal force by 14.4±19.7% (P=0.02), vastus lateralis thickness by 10.7±8.6% (P=0.01), vastus lateralis MFCV by 11.1±3.5% (P<0.001), vastus medialis MFCV by 8.4±1.8% (P<0.001). The whole spectrum of possible MHC isoform adaptations to training was observed: fast-to-slow transition (4 subjects), bi-directional transformation from MHC-1 and MHC-2X isoforms toward MHC-2A isoform (7 subjects), shift toward MHC-2X (2 subjects), no MHC distribution change (1 subject). No significant correlation was observed between MHC-2 relative content and vastus lateralis MFCV (pre-training: R2=0.04, P=0.46; post-training: R2=0.02, P=0.67). NMES elicited distinct adaptations in the MHC composition and increased force, muscle thickness, and MFCV. The MHC isoform distribution did not correlate with MFCV, thus implying that the proportion of different fibre types cannot be estimated from this electrophysiological variable. SN - 1439-3964 UR - https://www.unboundmedicine.com/medline/citation/23296400/Variability_in_muscle_adaptation_to_electrical_stimulation_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1321799 DB - PRIME DP - Unbound Medicine ER -