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The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects.
J Appl Toxicol. 2013 Apr; 33(4):246-64.JA

Abstract

Considerable progress has been made, recently, in understanding the role of the endocannabinoid system in regard to neuroprotection. Endogenous cannabinoids have received increasing attention as potential protective agents in several cases of neuronal injury. The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids) and proteins responsible for their metabolism. Endocannabinoids serve as retrograde signalling messengers in GABAergic and glutamatergic synapses, as well as modulators of post-synaptic transmission, interacting with other neurotransmitters, including norepinephrine and dopamine. Furthermore, endocannabinoids modulate neuronal, glial and endothelial cell function and exert neuromodulatory, anti-excitotoxic, anti-inflammatory and vasodilatory effects. Physiological stimuli and pathological conditions lead to differential increases in brain endocannabinoids that regulate distinct biological functions. The purpose of this review is to present the available in vivo and in vitro experimental data, up to date, regarding the endocannabinoid system and its role in neuroprotection, as well as its possible therapeutic perspectives.

Authors+Show Affiliations

1st Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23296873

Citation

Zogopoulos, Panagiotis, et al. "The Neuroprotective Role of Endocannabinoids Against Chemical-induced Injury and Other Adverse Effects." Journal of Applied Toxicology : JAT, vol. 33, no. 4, 2013, pp. 246-64.
Zogopoulos P, Vasileiou I, Patsouris E, et al. The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects. J Appl Toxicol. 2013;33(4):246-64.
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. (2013). The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects. Journal of Applied Toxicology : JAT, 33(4), 246-64. https://doi.org/10.1002/jat.2828
Zogopoulos P, et al. The Neuroprotective Role of Endocannabinoids Against Chemical-induced Injury and Other Adverse Effects. J Appl Toxicol. 2013;33(4):246-64. PubMed PMID: 23296873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuroprotective role of endocannabinoids against chemical-induced injury and other adverse effects. AU - Zogopoulos,Panagiotis, AU - Vasileiou,Ioanna, AU - Patsouris,Efstratios, AU - Theocharis,Stamatios, Y1 - 2013/01/08/ PY - 2012/07/05/received PY - 2012/08/31/revised PY - 2012/09/01/accepted PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/7/10/medline SP - 246 EP - 64 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 33 IS - 4 N2 - Considerable progress has been made, recently, in understanding the role of the endocannabinoid system in regard to neuroprotection. Endogenous cannabinoids have received increasing attention as potential protective agents in several cases of neuronal injury. The endocannabinoid system is comprised of cannabinoid receptors (CB1 and CB2), their endogenous ligands (endocannabinoids) and proteins responsible for their metabolism. Endocannabinoids serve as retrograde signalling messengers in GABAergic and glutamatergic synapses, as well as modulators of post-synaptic transmission, interacting with other neurotransmitters, including norepinephrine and dopamine. Furthermore, endocannabinoids modulate neuronal, glial and endothelial cell function and exert neuromodulatory, anti-excitotoxic, anti-inflammatory and vasodilatory effects. Physiological stimuli and pathological conditions lead to differential increases in brain endocannabinoids that regulate distinct biological functions. The purpose of this review is to present the available in vivo and in vitro experimental data, up to date, regarding the endocannabinoid system and its role in neuroprotection, as well as its possible therapeutic perspectives. SN - 1099-1263 UR - https://www.unboundmedicine.com/medline/citation/23296873/The_neuroprotective_role_of_endocannabinoids_against_chemical-induced_injury_and_other_adverse_effects L2 - https://doi.org/10.1002/jat.2828 DB - PRIME DP - Unbound Medicine ER -