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Human rhinoviruses.
Clin Microbiol Rev. 2013 Jan; 26(1):135-62.CM

Abstract

Human rhinoviruses (HRVs), first discovered in the 1950s, are responsible for more than one-half of cold-like illnesses and cost billions of dollars annually in medical visits and missed days of work. Advances in molecular methods have enhanced our understanding of the genomic structure of HRV and have led to the characterization of three genetically distinct HRV groups, designated groups A, B, and C, within the genus Enterovirus and the family Picornaviridae. HRVs are traditionally associated with upper respiratory tract infection, otitis media, and sinusitis. In recent years, the increasing implementation of PCR assays for respiratory virus detection in clinical laboratories has facilitated the recognition of HRV as a lower respiratory tract pathogen, particularly in patients with asthma, infants, elderly patients, and immunocompromised hosts. Cultured isolates of HRV remain important for studies of viral characteristics and disease pathogenesis. Indeed, whether the clinical manifestations of HRV are related directly to viral pathogenicity or secondary to the host immune response is the subject of ongoing research. There are currently no approved antiviral therapies for HRVs, and treatment remains primarily supportive. This review provides a comprehensive, up-to-date assessment of the basic virology, pathogenesis, clinical epidemiology, and laboratory features of and treatment and prevention strategies for HRVs.

Authors+Show Affiliations

Transplantation-Oncology Infectious Diseases Program, Division of Infectious Diseases, Weill Cornell Medical College, New York, New York, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23297263

Citation

Jacobs, Samantha E., et al. "Human Rhinoviruses." Clinical Microbiology Reviews, vol. 26, no. 1, 2013, pp. 135-62.
Jacobs SE, Lamson DM, St George K, et al. Human rhinoviruses. Clin Microbiol Rev. 2013;26(1):135-62.
Jacobs, S. E., Lamson, D. M., St George, K., & Walsh, T. J. (2013). Human rhinoviruses. Clinical Microbiology Reviews, 26(1), 135-62. https://doi.org/10.1128/CMR.00077-12
Jacobs SE, et al. Human Rhinoviruses. Clin Microbiol Rev. 2013;26(1):135-62. PubMed PMID: 23297263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human rhinoviruses. AU - Jacobs,Samantha E, AU - Lamson,Daryl M, AU - St George,Kirsten, AU - Walsh,Thomas J, PY - 2013/1/9/entrez PY - 2013/1/9/pubmed PY - 2013/6/12/medline SP - 135 EP - 62 JF - Clinical microbiology reviews JO - Clin Microbiol Rev VL - 26 IS - 1 N2 - Human rhinoviruses (HRVs), first discovered in the 1950s, are responsible for more than one-half of cold-like illnesses and cost billions of dollars annually in medical visits and missed days of work. Advances in molecular methods have enhanced our understanding of the genomic structure of HRV and have led to the characterization of three genetically distinct HRV groups, designated groups A, B, and C, within the genus Enterovirus and the family Picornaviridae. HRVs are traditionally associated with upper respiratory tract infection, otitis media, and sinusitis. In recent years, the increasing implementation of PCR assays for respiratory virus detection in clinical laboratories has facilitated the recognition of HRV as a lower respiratory tract pathogen, particularly in patients with asthma, infants, elderly patients, and immunocompromised hosts. Cultured isolates of HRV remain important for studies of viral characteristics and disease pathogenesis. Indeed, whether the clinical manifestations of HRV are related directly to viral pathogenicity or secondary to the host immune response is the subject of ongoing research. There are currently no approved antiviral therapies for HRVs, and treatment remains primarily supportive. This review provides a comprehensive, up-to-date assessment of the basic virology, pathogenesis, clinical epidemiology, and laboratory features of and treatment and prevention strategies for HRVs. SN - 1098-6618 UR - https://www.unboundmedicine.com/medline/citation/23297263/Human_rhinoviruses_ L2 - https://journals.asm.org/doi/10.1128/CMR.00077-12?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -