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Polymeric "smart" coatings to prevent foreign body response to implantable biosensors.
J Control Release. 2013 Aug 10; 169(3):341-7.JC

Abstract

Application of implantable glucose biosensors for "real-time" monitoring is reliant on controlling the negative tissue reaction at the sensor tissue interphase. A novel polymer coating consisting of poly(lactic-co-glycolic) acid (PLGA) microsphere dispersed in poly(vinyl alcohol) (PVA) hydrogels was evaluated in combination with dummy sensors as a "smart" drug eluting biocompatible coating for implantable biosensors to prevent the foreign body response, and thus enhance sensor performance in vivo. The polymeric microspheres slowly release tissue-modifying drugs at the implantation sites to control the inflammation and fibrous encapsulation, while the hydrogel allows rapid analyte diffusion to the sensing elements. Dummy sensors with identical dimensions to that of the functional glucose sensors (0.5×0.5×5mm) were coated with the PLGA/PVA composites using a mold fabrication process. Both normal and diabetic rats were used in the current study to investigate the effect of the diabetic state on tissue sensor interactions. It was evident that the PLGA/PVA hydrogel composite was able to form a uniform coating around the dummy sensor and stayed intact throughout the course of the study (one month). Tissue samples containing dummy sensors that were coated with dexamethasone free composites exhibited acute and chronic inflammation as well as fibrous encapsulation in both normal and diabetic rats. However, the diabetic rats exhibited decreased intensity and delayed onset of the foreign body response following implantation of drug free dummy sensors in comparison to those of normal rats. On the other hand, tissues containing dummy sensors that were coated with dexamethasone containing composites remained normal (i.e. similar to untreated tissues), with no inflammatory reaction or fibrous encapsulation occurring over the one-month period in both the normal and diabetic rats. The feasibility of utilizing PLGA microsphere/PVA hydrogel composites as coatings for implantable biosensors was demonstrated. This polymeric composite is an innovative approach to control the foreign body reaction at the tissue-device interface to prolong biosensor lifetime.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd U3092, Storrs, CT 06269, United States. wangyan.nj@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23298616

Citation

Wang, Yan, et al. "Polymeric "smart" Coatings to Prevent Foreign Body Response to Implantable Biosensors." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 169, no. 3, 2013, pp. 341-7.
Wang Y, Papadimitrakopoulos F, Burgess DJ. Polymeric "smart" coatings to prevent foreign body response to implantable biosensors. J Control Release. 2013;169(3):341-7.
Wang, Y., Papadimitrakopoulos, F., & Burgess, D. J. (2013). Polymeric "smart" coatings to prevent foreign body response to implantable biosensors. Journal of Controlled Release : Official Journal of the Controlled Release Society, 169(3), 341-7. https://doi.org/10.1016/j.jconrel.2012.12.028
Wang Y, Papadimitrakopoulos F, Burgess DJ. Polymeric "smart" Coatings to Prevent Foreign Body Response to Implantable Biosensors. J Control Release. 2013 Aug 10;169(3):341-7. PubMed PMID: 23298616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymeric "smart" coatings to prevent foreign body response to implantable biosensors. AU - Wang,Yan, AU - Papadimitrakopoulos,Fotios, AU - Burgess,Diane J, Y1 - 2013/01/05/ PY - 2012/10/13/received PY - 2012/12/09/revised PY - 2012/12/25/accepted PY - 2013/1/10/entrez PY - 2013/1/10/pubmed PY - 2014/1/11/medline SP - 341 EP - 7 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 169 IS - 3 N2 - Application of implantable glucose biosensors for "real-time" monitoring is reliant on controlling the negative tissue reaction at the sensor tissue interphase. A novel polymer coating consisting of poly(lactic-co-glycolic) acid (PLGA) microsphere dispersed in poly(vinyl alcohol) (PVA) hydrogels was evaluated in combination with dummy sensors as a "smart" drug eluting biocompatible coating for implantable biosensors to prevent the foreign body response, and thus enhance sensor performance in vivo. The polymeric microspheres slowly release tissue-modifying drugs at the implantation sites to control the inflammation and fibrous encapsulation, while the hydrogel allows rapid analyte diffusion to the sensing elements. Dummy sensors with identical dimensions to that of the functional glucose sensors (0.5×0.5×5mm) were coated with the PLGA/PVA composites using a mold fabrication process. Both normal and diabetic rats were used in the current study to investigate the effect of the diabetic state on tissue sensor interactions. It was evident that the PLGA/PVA hydrogel composite was able to form a uniform coating around the dummy sensor and stayed intact throughout the course of the study (one month). Tissue samples containing dummy sensors that were coated with dexamethasone free composites exhibited acute and chronic inflammation as well as fibrous encapsulation in both normal and diabetic rats. However, the diabetic rats exhibited decreased intensity and delayed onset of the foreign body response following implantation of drug free dummy sensors in comparison to those of normal rats. On the other hand, tissues containing dummy sensors that were coated with dexamethasone containing composites remained normal (i.e. similar to untreated tissues), with no inflammatory reaction or fibrous encapsulation occurring over the one-month period in both the normal and diabetic rats. The feasibility of utilizing PLGA microsphere/PVA hydrogel composites as coatings for implantable biosensors was demonstrated. This polymeric composite is an innovative approach to control the foreign body reaction at the tissue-device interface to prolong biosensor lifetime. SN - 1873-4995 UR - https://www.unboundmedicine.com/medline/citation/23298616/Polymeric_"smart"_coatings_to_prevent_foreign_body_response_to_implantable_biosensors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-3659(12)00870-X DB - PRIME DP - Unbound Medicine ER -