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Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study.
Clin Neurol Neurosurg. 2013 Aug; 115(8):1317-21.CN

Abstract

BACKGROUND AND PURPOSE

Magnetization transfer imaging detects cerebral microstructural tissue alterations. We examined the association between the Framingham Stroke Risk Profile (FSRP) score and magnetization transfer imaging (MTI) measures in pathological and normal appearing brain tissue in clinically normal elderly subjects to determine if stroke risk leads to brain tissue destruction beyond what is visible in conventional MRI scans.

METHODS

The study cohort is from the Austrian Stroke Prevention Study (ASPS). A total of 316 subjects underwent MTI and had a complete risk factor assessment sufficient to calculate the FSRP score. There were 205 women and 111 men with a mean age of 70.2 years ranging from 54 to 82 years. Subjects were grouped into four categories of stroke risk probability ranging from 3% to 88% for men and 1% to 84% for women.

RESULTS

A higher FSRP score was significantly and independently associated with a MTR peak position shift indicating global microstructural alterations in brain tissue (BT) and in normal appearing brain tissue (NABT). The mean MTR in white matter hyperintensities (WMH) correlated inversely with increasing stroke risk. Age explained most of the variance in MTR peak position, all other risk factors of the FSRP score contributed significantly but explained an additional 2% of the variance of this MRI measure, only.

CONCLUSION

Increasing risk for stroke leads to microstructural brain changes invisible by standard MRI. The validity, the underlying pathogenic mechanisms and the clinical importance of these abnormalities needs to be further determined.

Authors+Show Affiliations

Department of Neurology, Division of Special Neurology, Medical University of Graz, Graz, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23298976

Citation

Homayoon, Nina, et al. "Microstructural Tissue Damage in Normal Appearing Brain Tissue Accumulates With Framingham Stroke Risk Profile Score: Magnetization Transfer Imaging Results of the Austrian Stroke Prevention Study." Clinical Neurology and Neurosurgery, vol. 115, no. 8, 2013, pp. 1317-21.
Homayoon N, Ropele S, Hofer E, et al. Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study. Clin Neurol Neurosurg. 2013;115(8):1317-21.
Homayoon, N., Ropele, S., Hofer, E., Schwingenschuh, P., Seiler, S., & Schmidt, R. (2013). Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study. Clinical Neurology and Neurosurgery, 115(8), 1317-21. https://doi.org/10.1016/j.clineuro.2012.12.016
Homayoon N, et al. Microstructural Tissue Damage in Normal Appearing Brain Tissue Accumulates With Framingham Stroke Risk Profile Score: Magnetization Transfer Imaging Results of the Austrian Stroke Prevention Study. Clin Neurol Neurosurg. 2013;115(8):1317-21. PubMed PMID: 23298976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study. AU - Homayoon,Nina, AU - Ropele,Stefan, AU - Hofer,Edith, AU - Schwingenschuh,Petra, AU - Seiler,Stephan, AU - Schmidt,Reinhold, Y1 - 2013/01/06/ PY - 2012/03/14/received PY - 2012/11/19/revised PY - 2012/12/13/accepted PY - 2013/1/10/entrez PY - 2013/1/10/pubmed PY - 2014/2/22/medline KW - Cerebrovascular risk factors KW - Magnetic resonance imaging KW - Magnetization transfer imaging KW - Stroke SP - 1317 EP - 21 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 115 IS - 8 N2 - BACKGROUND AND PURPOSE: Magnetization transfer imaging detects cerebral microstructural tissue alterations. We examined the association between the Framingham Stroke Risk Profile (FSRP) score and magnetization transfer imaging (MTI) measures in pathological and normal appearing brain tissue in clinically normal elderly subjects to determine if stroke risk leads to brain tissue destruction beyond what is visible in conventional MRI scans. METHODS: The study cohort is from the Austrian Stroke Prevention Study (ASPS). A total of 316 subjects underwent MTI and had a complete risk factor assessment sufficient to calculate the FSRP score. There were 205 women and 111 men with a mean age of 70.2 years ranging from 54 to 82 years. Subjects were grouped into four categories of stroke risk probability ranging from 3% to 88% for men and 1% to 84% for women. RESULTS: A higher FSRP score was significantly and independently associated with a MTR peak position shift indicating global microstructural alterations in brain tissue (BT) and in normal appearing brain tissue (NABT). The mean MTR in white matter hyperintensities (WMH) correlated inversely with increasing stroke risk. Age explained most of the variance in MTR peak position, all other risk factors of the FSRP score contributed significantly but explained an additional 2% of the variance of this MRI measure, only. CONCLUSION: Increasing risk for stroke leads to microstructural brain changes invisible by standard MRI. The validity, the underlying pathogenic mechanisms and the clinical importance of these abnormalities needs to be further determined. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/23298976/Microstructural_tissue_damage_in_normal_appearing_brain_tissue_accumulates_with_Framingham_Stroke_Risk_Profile_Score:_magnetization_transfer_imaging_results_of_the_Austrian_Stroke_Prevention_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(12)00626-9 DB - PRIME DP - Unbound Medicine ER -