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Burden of norovirus gastroenteritis in the ambulatory setting--United States, 2001-2009.
J Infect Dis. 2013 Apr; 207(7):1058-65.JI

Abstract

BACKGROUND

Gastroenteritis remains an important cause of morbidity in the United States. The burden of norovirus gastroenteritis in ambulatory US patients is not well understood.

METHODS

Cause-specified and cause-unspecified gastroenteritis emergency department (ED) and outpatient visits during July 2001-June 2009 were extracted from MarketScan insurance claim databases. By using cause-specified encounters, time-series regression models were fitted to predict the number of unspecified gastroenteritis visits due to specific pathogens other than norovirus. Model residuals were used to estimate norovirus visits. MarketScan rates were extrapolated to the US population to estimate national ambulatory visits.

RESULTS

During 2001-2009, the estimated annual mean rates of norovirus-associated ED and outpatient visits were 14 and 57 cases per 10 000 persons, respectively, across all ages. Rates for ages 0-4, 5-17, 18-64, and ≥65 years were 38, 10, 12, and 15 ED visits per 10 000 persons, respectively, and 233, 85, 35, and 54 outpatient visits per 10 000 persons, respectively. Norovirus was estimated to cause 13% of all gastroenteritis-associated ambulatory visits, with ~50% of such visits occurring during November-February. Nationally, norovirus contributed to approximately 400 000 ED visits and 1.7 million office visits annually, resulting in $284 million in healthcare charges.

CONCLUSIONS

Norovirus is a substantial cause of gastroenteritis in the ambulatory setting.

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Authors+Show Affiliations

Gastañaduy PA
Epidemic Intelligence Service, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. pgastanaduy@cdc.gov
Hall AJ
No affiliation info available
Curns AT
No affiliation info available
Parashar UD
No affiliation info available
Lopman BA
No affiliation info available

MeSH

AdolescentAdultAgedAmbulatory CareAmbulatory Care FacilitiesCaliciviridae InfectionsChildChild, PreschoolDatabases, FactualGastroenteritisHealth Care CostsHumansIncidenceInfantMiddle AgedNorovirusRegression AnalysisRotavirusRotavirus InfectionsSeasonsUnited StatesYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23300161

Citation

Gastañaduy, Paul A., et al. "Burden of Norovirus Gastroenteritis in the Ambulatory setting--United States, 2001-2009." The Journal of Infectious Diseases, vol. 207, no. 7, 2013, pp. 1058-65.
Gastañaduy PA, Hall AJ, Curns AT, et al. Burden of norovirus gastroenteritis in the ambulatory setting--United States, 2001-2009. J Infect Dis. 2013;207(7):1058-65.
Gastañaduy, P. A., Hall, A. J., Curns, A. T., Parashar, U. D., & Lopman, B. A. (2013). Burden of norovirus gastroenteritis in the ambulatory setting--United States, 2001-2009. The Journal of Infectious Diseases, 207(7), 1058-65. https://doi.org/10.1093/infdis/jis942
Gastañaduy PA, et al. Burden of Norovirus Gastroenteritis in the Ambulatory setting--United States, 2001-2009. J Infect Dis. 2013;207(7):1058-65. PubMed PMID: 23300161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden of norovirus gastroenteritis in the ambulatory setting--United States, 2001-2009. AU - Gastañaduy,Paul A, AU - Hall,Aron J, AU - Curns,Aaron T, AU - Parashar,Umesh D, AU - Lopman,Benjamin A, Y1 - 2013/01/08/ PY - 2013/1/10/entrez PY - 2013/1/10/pubmed PY - 2013/4/20/medline SP - 1058 EP - 65 JF - The Journal of infectious diseases JO - J Infect Dis VL - 207 IS - 7 N2 - BACKGROUND: Gastroenteritis remains an important cause of morbidity in the United States. The burden of norovirus gastroenteritis in ambulatory US patients is not well understood. METHODS: Cause-specified and cause-unspecified gastroenteritis emergency department (ED) and outpatient visits during July 2001-June 2009 were extracted from MarketScan insurance claim databases. By using cause-specified encounters, time-series regression models were fitted to predict the number of unspecified gastroenteritis visits due to specific pathogens other than norovirus. Model residuals were used to estimate norovirus visits. MarketScan rates were extrapolated to the US population to estimate national ambulatory visits. RESULTS: During 2001-2009, the estimated annual mean rates of norovirus-associated ED and outpatient visits were 14 and 57 cases per 10 000 persons, respectively, across all ages. Rates for ages 0-4, 5-17, 18-64, and ≥65 years were 38, 10, 12, and 15 ED visits per 10 000 persons, respectively, and 233, 85, 35, and 54 outpatient visits per 10 000 persons, respectively. Norovirus was estimated to cause 13% of all gastroenteritis-associated ambulatory visits, with ~50% of such visits occurring during November-February. Nationally, norovirus contributed to approximately 400 000 ED visits and 1.7 million office visits annually, resulting in $284 million in healthcare charges. CONCLUSIONS: Norovirus is a substantial cause of gastroenteritis in the ambulatory setting. SN - 1537-6613 UR - https://www.unboundmedicine.com/medline/citation/23300161/Burden_of_norovirus_gastroenteritis_in_the_ambulatory_setting__United_States_2001_2009_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/jis942 DB - PRIME DP - Unbound Medicine ER -