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The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia.
mBio. 2013 Jan 08; 4(1):e00548-12.MBIO

Abstract

A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the viral genomic RNA showed that it is a novel virus not previously detected in any other species and that its closest relatives are two Asian bat coronaviruses. HCoV-EMC may represent a sporadic spillover to humans from an unknown animal reservoir. In a recent article, van Boheemen et al. demonstrated how state-of-the-art sequencing technology and bioinformatic analysis can quickly provide critical insight into the viral genome sequence, phylogeny, replication strategy, and potential drug and vaccine targets and generate tools to evaluate the possible epidemic risk associated with this novel human virus.

Authors+Show Affiliations

Department of Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA. Kathryn.Holmes@ucdenver.eduNo affiliation info available

Pub Type(s)

Journal Article
Comment

Language

eng

PubMed ID

23300251

Citation

Holmes, Kathryn V., and Samuel R. Dominguez. "The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated From a Fatal Case of Pneumonia." MBio, vol. 4, no. 1, 2013, pp. e00548-12.
Holmes KV, Dominguez SR. The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia. mBio. 2013;4(1):e00548-12.
Holmes, K. V., & Dominguez, S. R. (2013). The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia. MBio, 4(1), e00548-12. https://doi.org/10.1128/mBio.00548-12
Holmes KV, Dominguez SR. The New Age of Virus Discovery: Genomic Analysis of a Novel Human Betacoronavirus Isolated From a Fatal Case of Pneumonia. mBio. 2013 Jan 8;4(1):e00548-12. PubMed PMID: 23300251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia. AU - Holmes,Kathryn V, AU - Dominguez,Samuel R, Y1 - 2013/01/08/ PY - 2013/1/10/entrez PY - 2013/1/10/pubmed PY - 2013/6/12/medline SP - e00548 EP - 12 JF - mBio JO - mBio VL - 4 IS - 1 N2 - A new human betacoronavirus in lineage c, tentatively called HCoV-EMC, was isolated from a patient from the Kingdom of Saudi Arabia who died from acute severe pneumonia and renal failure. The viral RNA has been detected in eight additional cases. Sequencing and bioinformatic analysis of the viral genomic RNA showed that it is a novel virus not previously detected in any other species and that its closest relatives are two Asian bat coronaviruses. HCoV-EMC may represent a sporadic spillover to humans from an unknown animal reservoir. In a recent article, van Boheemen et al. demonstrated how state-of-the-art sequencing technology and bioinformatic analysis can quickly provide critical insight into the viral genome sequence, phylogeny, replication strategy, and potential drug and vaccine targets and generate tools to evaluate the possible epidemic risk associated with this novel human virus. SN - 2150-7511 UR - https://www.unboundmedicine.com/medline/citation/23300251/The_new_age_of_virus_discovery:_genomic_analysis_of_a_novel_human_betacoronavirus_isolated_from_a_fatal_case_of_pneumonia_ L2 - http://mbio.asm.org/cgi/pmidlookup?view=long&pmid=23300251 DB - PRIME DP - Unbound Medicine ER -