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Perianal Paget disease treated definitively with radiotherapy.
Curr Oncol 2012; 19(6):e496-500CO

Abstract

Extramammary Paget disease (empd) is a relatively rare cutaneous disorder described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. The areas of the body affected are the vulva, perianal region, penis, scrotum, perineum, and axilla, all of which contain apocrine glands. When empd affects the perianal region, it is called perianal Paget disease (ppd). All forms of empd, including ppd, are typically treated by wide surgical excision. Perianal Paget disease usually occurs later in life in patients who are often poor surgical candidates, but the available literature is scarce regarding other treatment modalities, including definitive radiotherapy. We contend that ppd can be safely and effectively treated with radiotherapy, and here, we present the case of a 75-year-old woman with ppd who was successfully so treated. A brief review of the literature concerning the diagnosis, natural history, and treatment of ppd is also included.

Authors+Show Affiliations

Department of Radiation Oncology, New York Methodist Hospital, Weill Cornell Medical College, Brooklyn, NY, U.S.A.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23300373

Citation

Mann, J, et al. "Perianal Paget Disease Treated Definitively With Radiotherapy." Current Oncology (Toronto, Ont.), vol. 19, no. 6, 2012, pp. e496-500.
Mann J, Lavaf A, Tejwani A, et al. Perianal Paget disease treated definitively with radiotherapy. Curr Oncol. 2012;19(6):e496-500.
Mann, J., Lavaf, A., Tejwani, A., Ross, P., & Ashamalla, H. (2012). Perianal Paget disease treated definitively with radiotherapy. Current Oncology (Toronto, Ont.), 19(6), pp. e496-500. doi:10.3747/co.19.1144.
Mann J, et al. Perianal Paget Disease Treated Definitively With Radiotherapy. Curr Oncol. 2012;19(6):e496-500. PubMed PMID: 23300373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perianal Paget disease treated definitively with radiotherapy. AU - Mann,J, AU - Lavaf,A, AU - Tejwani,A, AU - Ross,P, AU - Ashamalla,H, PY - 2013/1/10/entrez PY - 2013/1/10/pubmed PY - 2013/1/10/medline KW - Perianal Paget disease KW - extramammary Paget disease KW - radiotherapy SP - e496 EP - 500 JF - Current oncology (Toronto, Ont.) JO - Curr Oncol VL - 19 IS - 6 N2 - Extramammary Paget disease (empd) is a relatively rare cutaneous disorder described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. The areas of the body affected are the vulva, perianal region, penis, scrotum, perineum, and axilla, all of which contain apocrine glands. When empd affects the perianal region, it is called perianal Paget disease (ppd). All forms of empd, including ppd, are typically treated by wide surgical excision. Perianal Paget disease usually occurs later in life in patients who are often poor surgical candidates, but the available literature is scarce regarding other treatment modalities, including definitive radiotherapy. We contend that ppd can be safely and effectively treated with radiotherapy, and here, we present the case of a 75-year-old woman with ppd who was successfully so treated. A brief review of the literature concerning the diagnosis, natural history, and treatment of ppd is also included. SN - 1198-0052 UR - https://www.unboundmedicine.com/medline/citation/23300373/Perianal_Paget_disease_treated_definitively_with_radiotherapy_ L2 - http://www.current-oncology.com/index.php/oncology/article/view/1144/1041 DB - PRIME DP - Unbound Medicine ER -