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[Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF].

Abstract

OBJECTIVE

To verify the efficacy on Parkinson's disease combined with depression treated with electroacupuncture and medication and to explore the therapeutic mechanism.

METHODS

Sixty cases of Parkinson's disease combined with depression were randomized into an acupuncture + medication group and a medication group, 30 cases in each one. The conventional therapeutic program of oral administration of madopar and fluoxetine was applied in both groups. In the acupuncture + medication group, on the basic treatment as the above, electroacupuncture was applied to Baihui (GV 20), Yintang (EX-HN 3), Sishencong (EX-HN 1), Taichong (LR 3) and Sanyinjiao (SP 6), etc. The level of the serum brain-derived neurotrophic factor (BDNF) and the score of Hamilton depression scale (HAMD) were observed and compared before treatment and after 3 months of treatment. The efficacy was assessed in two groups.

RESULTS

The level of BDFN was improved significantly after treatment as compared with that before treatment in two groups (both P < 0.05) and the result in the acupuncture + medication group was superior to the medication group (P < 0.05). HAMD scores were reduced significantly after treatment as compared with those before treatment in two groups (both P < 0.05) and the result in the acupuncture + medication group was superior to the medication group (P < 0.05). The total effective rate was 90.0% (27/30) in the acupuncture + medication group, which was better than 83.3% (25/30) in the medication group (P < 0.05).

CONCLUSION

The combined therapy of electroacupuncture and medication achieves the significant efficacy on Parkinson's disease combined with depression. This therapy regulates effectively serum BDNF level, relieves depression symptoms of the patients. The efficacy of electroacupuncture combined with medication is superior to the simple medication.

Authors+Show Affiliations

,

Department of TCM, Affiliated Brain Hospital of Nanjing Medical Univerity, Nanjing 210029, Jiangsu Province, China. 88750@sina.com

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Source

MeSH

Acupuncture Points
Adult
Aged
Brain-Derived Neurotrophic Factor
Depression
Electroacupuncture
Female
Humans
Male
Middle Aged
Parkinson Disease

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

23301468

Citation

Xia, Yi, et al. "[Parkinson's Disease Combined With Depression Treated With Electroacupuncture and Medication and Its Effect On Serum BDNF]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 32, no. 12, 2012, pp. 1071-4.
Xia Y, Wang HD, Ding Y, et al. [Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF]. Zhongguo Zhen Jiu. 2012;32(12):1071-4.
Xia, Y., Wang, H. D., Ding, Y., Kang, B., & Liu, W. G. (2012). [Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 32(12), pp. 1071-4.
Xia Y, et al. [Parkinson's Disease Combined With Depression Treated With Electroacupuncture and Medication and Its Effect On Serum BDNF]. Zhongguo Zhen Jiu. 2012;32(12):1071-4. PubMed PMID: 23301468.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF]. AU - Xia,Yi, AU - Wang,Hai-Dong, AU - Ding,Ying, AU - Kang,Bing, AU - Liu,Wei-Guo, PY - 2013/1/11/entrez PY - 2013/1/11/pubmed PY - 2013/2/8/medline SP - 1071 EP - 4 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 32 IS - 12 N2 - OBJECTIVE: To verify the efficacy on Parkinson's disease combined with depression treated with electroacupuncture and medication and to explore the therapeutic mechanism. METHODS: Sixty cases of Parkinson's disease combined with depression were randomized into an acupuncture + medication group and a medication group, 30 cases in each one. The conventional therapeutic program of oral administration of madopar and fluoxetine was applied in both groups. In the acupuncture + medication group, on the basic treatment as the above, electroacupuncture was applied to Baihui (GV 20), Yintang (EX-HN 3), Sishencong (EX-HN 1), Taichong (LR 3) and Sanyinjiao (SP 6), etc. The level of the serum brain-derived neurotrophic factor (BDNF) and the score of Hamilton depression scale (HAMD) were observed and compared before treatment and after 3 months of treatment. The efficacy was assessed in two groups. RESULTS: The level of BDFN was improved significantly after treatment as compared with that before treatment in two groups (both P < 0.05) and the result in the acupuncture + medication group was superior to the medication group (P < 0.05). HAMD scores were reduced significantly after treatment as compared with those before treatment in two groups (both P < 0.05) and the result in the acupuncture + medication group was superior to the medication group (P < 0.05). The total effective rate was 90.0% (27/30) in the acupuncture + medication group, which was better than 83.3% (25/30) in the medication group (P < 0.05). CONCLUSION: The combined therapy of electroacupuncture and medication achieves the significant efficacy on Parkinson's disease combined with depression. This therapy regulates effectively serum BDNF level, relieves depression symptoms of the patients. The efficacy of electroacupuncture combined with medication is superior to the simple medication. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/23301468/[Parkinson's_disease_combined_with_depression_treated_with_electroacupuncture_and_medication_and_its_effect_on_serum_BDNF]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -