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Photopic negative response versus pattern electroretinogram in early glaucoma.
Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):1182-91.IO

Abstract

PURPOSE

Photopic negative response (PhNR) and pattern electroretinogram (PERG) are electrophysiological markers of retinal ganglion cell function; both are reduced in glaucoma. We compared PhNR and PERG in different stages of the disease.

METHODS

Eleven eyes with preperimetric glaucoma (glaucomatous optic disc with normal field); 18 with manifest glaucoma; and 26 normals were included. We obtained PhNR (flash strength from 0.1-4 cd·s/m(2)) and steady-state PERG and analyzed PhNR amplitude (baseline to 72 ms trough); PhNR/b-wave ratio; PERG amplitude; and PERG ratio (0.8°/16°).

RESULTS

Identification of PhNR structure was only reliable ≥1 cd·s/m(2) flash strength; amplitude and receiver operating characteristics (ROC) area under curve (AUC) changed little from 1 to 4 cd·s/m(2). Both PhNR and PERG (amplitude and ratio) were reduced in preperimetric and more so in manifest glaucoma. AUCs based on PhNR/PERG amplitudes were not significantly different from chance in preperimetric glaucoma (AUCs 0.61/0.59), but were significant in manifest glaucoma (0.78/0.76); ratios were significant in both glaucoma groups (0.80/0.73 and 0.80/0.79). In spite of that, PhNR ratio and PERG ratio were not significantly correlated (r = 0.22 across all groups); an ROC based on a combination of both reached AUCs of 0.85/0.90 for preperimetric/manifest glaucoma.

CONCLUSIONS

Both PhNR and PERG performed similarly to detect glaucoma; for both, ratios performed better than amplitudes. The PhNR has the advantage of not requiring clear optics and refractive correction; the PERG has the advantage of being recorded with natural pupils.

Authors+Show Affiliations

Section Visual Function, Department of Ophthalmology, University of Freiburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

23307968

Citation

Preiser, Dunja, et al. "Photopic Negative Response Versus Pattern Electroretinogram in Early Glaucoma." Investigative Ophthalmology & Visual Science, vol. 54, no. 2, 2013, pp. 1182-91.
Preiser D, Lagrèze WA, Bach M, et al. Photopic negative response versus pattern electroretinogram in early glaucoma. Invest Ophthalmol Vis Sci. 2013;54(2):1182-91.
Preiser, D., Lagrèze, W. A., Bach, M., & Poloschek, C. M. (2013). Photopic negative response versus pattern electroretinogram in early glaucoma. Investigative Ophthalmology & Visual Science, 54(2), 1182-91. https://doi.org/10.1167/iovs.12-11201
Preiser D, et al. Photopic Negative Response Versus Pattern Electroretinogram in Early Glaucoma. Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):1182-91. PubMed PMID: 23307968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photopic negative response versus pattern electroretinogram in early glaucoma. AU - Preiser,Dunja, AU - Lagrèze,Wolf A, AU - Bach,Michael, AU - Poloschek,Charlotte M, Y1 - 2013/02/01/ PY - 2013/1/12/entrez PY - 2013/1/12/pubmed PY - 2013/4/10/medline SP - 1182 EP - 91 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 54 IS - 2 N2 - PURPOSE: Photopic negative response (PhNR) and pattern electroretinogram (PERG) are electrophysiological markers of retinal ganglion cell function; both are reduced in glaucoma. We compared PhNR and PERG in different stages of the disease. METHODS: Eleven eyes with preperimetric glaucoma (glaucomatous optic disc with normal field); 18 with manifest glaucoma; and 26 normals were included. We obtained PhNR (flash strength from 0.1-4 cd·s/m(2)) and steady-state PERG and analyzed PhNR amplitude (baseline to 72 ms trough); PhNR/b-wave ratio; PERG amplitude; and PERG ratio (0.8°/16°). RESULTS: Identification of PhNR structure was only reliable ≥1 cd·s/m(2) flash strength; amplitude and receiver operating characteristics (ROC) area under curve (AUC) changed little from 1 to 4 cd·s/m(2). Both PhNR and PERG (amplitude and ratio) were reduced in preperimetric and more so in manifest glaucoma. AUCs based on PhNR/PERG amplitudes were not significantly different from chance in preperimetric glaucoma (AUCs 0.61/0.59), but were significant in manifest glaucoma (0.78/0.76); ratios were significant in both glaucoma groups (0.80/0.73 and 0.80/0.79). In spite of that, PhNR ratio and PERG ratio were not significantly correlated (r = 0.22 across all groups); an ROC based on a combination of both reached AUCs of 0.85/0.90 for preperimetric/manifest glaucoma. CONCLUSIONS: Both PhNR and PERG performed similarly to detect glaucoma; for both, ratios performed better than amplitudes. The PhNR has the advantage of not requiring clear optics and refractive correction; the PERG has the advantage of being recorded with natural pupils. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/23307968/Photopic_negative_response_versus_pattern_electroretinogram_in_early_glaucoma_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.12-11201 DB - PRIME DP - Unbound Medicine ER -