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Ultrastructural localization of endogenous peroxidase activity in Hashimoto's thyroiditis.
Acta Med Okayama. 1990 Feb; 44(1):21-33.AM

Abstract

Ultrastructural localization and intensity of endogenous thyroid peroxidase (TPO) in Hashimoto's thyroiditis were examined in relation to the serum thyroid hormone level, thyroid-stimulating hormone (TSH) concentration and anti-thyroid autoantibody titer. In Hashimoto's thyroiditis, TPO activity on the microvilli of follicular cells was more intense than that of normal thyroid tissue, but the intensity of the intracytoplasmic peroxidase reaction was generally weaker than that of Graves' or normal thyroid tissue. Microvillar TPO reaction products were positive in all thyroid follicular cells in patients with increased TSH levels, but no TPO activity was observed on the microvilli of patients with normal or low TSH levels, irrespective of their histological type or serum anti-microsomal antibody titer. It is suggested that TPO activity on the surface of microvilli of thyroid follicular cells in Hashimoto's thyroid gland is modulated by thyrotropin but is not affected by anti-thyroid autoantibodies.

Authors+Show Affiliations

Third Department of Internal Medicine, Okayama University Medical School, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2330843

Citation

Yamamoto, N, et al. "Ultrastructural Localization of Endogenous Peroxidase Activity in Hashimoto's Thyroiditis." Acta Medica Okayama, vol. 44, no. 1, 1990, pp. 21-33.
Yamamoto N, Suzuki S, Ota Z. Ultrastructural localization of endogenous peroxidase activity in Hashimoto's thyroiditis. Acta Med Okayama. 1990;44(1):21-33.
Yamamoto, N., Suzuki, S., & Ota, Z. (1990). Ultrastructural localization of endogenous peroxidase activity in Hashimoto's thyroiditis. Acta Medica Okayama, 44(1), 21-33.
Yamamoto N, Suzuki S, Ota Z. Ultrastructural Localization of Endogenous Peroxidase Activity in Hashimoto's Thyroiditis. Acta Med Okayama. 1990;44(1):21-33. PubMed PMID: 2330843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructural localization of endogenous peroxidase activity in Hashimoto's thyroiditis. AU - Yamamoto,N, AU - Suzuki,S, AU - Ota,Z, PY - 1990/2/1/pubmed PY - 1990/2/1/medline PY - 1990/2/1/entrez SP - 21 EP - 33 JF - Acta medica Okayama JO - Acta Med. Okayama VL - 44 IS - 1 N2 - Ultrastructural localization and intensity of endogenous thyroid peroxidase (TPO) in Hashimoto's thyroiditis were examined in relation to the serum thyroid hormone level, thyroid-stimulating hormone (TSH) concentration and anti-thyroid autoantibody titer. In Hashimoto's thyroiditis, TPO activity on the microvilli of follicular cells was more intense than that of normal thyroid tissue, but the intensity of the intracytoplasmic peroxidase reaction was generally weaker than that of Graves' or normal thyroid tissue. Microvillar TPO reaction products were positive in all thyroid follicular cells in patients with increased TSH levels, but no TPO activity was observed on the microvilli of patients with normal or low TSH levels, irrespective of their histological type or serum anti-microsomal antibody titer. It is suggested that TPO activity on the surface of microvilli of thyroid follicular cells in Hashimoto's thyroid gland is modulated by thyrotropin but is not affected by anti-thyroid autoantibodies. SN - 0386-300X UR - https://www.unboundmedicine.com/medline/citation/2330843/Ultrastructural_localization_of_endogenous_peroxidase_activity_in_Hashimoto's_thyroiditis_ DB - PRIME DP - Unbound Medicine ER -