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Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis.
J Matern Fetal Neonatal Med. 2013 Jun; 26(9):889-99.JM

Abstract

OBJECTIVE

To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes.

STUDY DESIGN

We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: "vitamin D" and "status" or "deficiency" or "insufficiency" and "pregnancy". A systematic review and meta-analysis were conducted on observational studies that reported the association between maternal blood vitamin D levels and adverse pregnancy outcomes including preeclampsia, gestational diabetes mellitus (GDM), preterm birth or small-for-gestational age (SGA).

RESULTS

Twenty-four studies met the inclusion criteria. Women with circulating 25-hydroxyvitamin D [25(OH)D] level less than 50 nmol/l in pregnancy experienced an increased risk of preeclampsia [odds ratio (OR) 2.09 (95% confidence intervals 1.50-2.90)], GDM [OR 1.38 (1.12-1.70)], preterm birth [OR 1.58 (1.08-2.31)] and SGA [OR 1.52 (1.08-2.15)].

CONCLUSION

Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, GDM, preterm birth and SGA.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Montreal, Montreal, Canada. shu.qin.wei@umontreal.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

23311886

Citation

Wei, Shu-Qin, et al. "Maternal Vitamin D Status and Adverse Pregnancy Outcomes: a Systematic Review and Meta-analysis." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, vol. 26, no. 9, 2013, pp. 889-99.
Wei SQ, Qi HP, Luo ZC, et al. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2013;26(9):889-99.
Wei, S. Q., Qi, H. P., Luo, Z. C., & Fraser, W. D. (2013). Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 26(9), 889-99. https://doi.org/10.3109/14767058.2013.765849
Wei SQ, et al. Maternal Vitamin D Status and Adverse Pregnancy Outcomes: a Systematic Review and Meta-analysis. J Matern Fetal Neonatal Med. 2013;26(9):889-99. PubMed PMID: 23311886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. AU - Wei,Shu-Qin, AU - Qi,Hui-Ping, AU - Luo,Zhong-Cheng, AU - Fraser,William D, Y1 - 2013/02/11/ PY - 2013/1/15/entrez PY - 2013/1/15/pubmed PY - 2014/1/11/medline SP - 889 EP - 99 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J Matern Fetal Neonatal Med VL - 26 IS - 9 N2 - OBJECTIVE: To estimate the associations between maternal vitamin D status and adverse pregnancy outcomes. STUDY DESIGN: We searched electronic databases of the human literature in PubMed, EMBASE and the Cochrane Library up to October, 2012 using the following keywords: "vitamin D" and "status" or "deficiency" or "insufficiency" and "pregnancy". A systematic review and meta-analysis were conducted on observational studies that reported the association between maternal blood vitamin D levels and adverse pregnancy outcomes including preeclampsia, gestational diabetes mellitus (GDM), preterm birth or small-for-gestational age (SGA). RESULTS: Twenty-four studies met the inclusion criteria. Women with circulating 25-hydroxyvitamin D [25(OH)D] level less than 50 nmol/l in pregnancy experienced an increased risk of preeclampsia [odds ratio (OR) 2.09 (95% confidence intervals 1.50-2.90)], GDM [OR 1.38 (1.12-1.70)], preterm birth [OR 1.58 (1.08-2.31)] and SGA [OR 1.52 (1.08-2.15)]. CONCLUSION: Low maternal vitamin D levels in pregnancy may be associated with an increased risk of preeclampsia, GDM, preterm birth and SGA. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/23311886/Maternal_vitamin_D_status_and_adverse_pregnancy_outcomes:_a_systematic_review_and_meta_analysis_ L2 - https://www.tandfonline.com/doi/full/10.3109/14767058.2013.765849 DB - PRIME DP - Unbound Medicine ER -