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Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia.
Br J Nutr. 2013 Aug 28; 110(3):426-36.BJ

Abstract

The present randomised parallel study assessed the impact of adding MUFA to a dietary portfolio of cholesterol-lowering foods on the intravascular kinetics of apoAI- and apoB-containing lipoproteins in subjects with dyslipidaemia. A sample of sixteen men and postmenopausal women consumed a run-in stabilisation diet for 4 weeks. Subjects were then randomly assigned to an experimental dietary portfolio either high or low in MUFA for another 4 weeks. MUFA substituted 13·0% of total energy from carbohydrate (CHO) in the high-MUFA dietary portfolio. Lipoprotein kinetics were assessed after the run-in and portfolio diets using a primed, constant infusion of [2H3]leucine and multicompartmental modelling. The high-MUFA dietary portfolio resulted in higher apoAI pool size (PS) compared with the low-MUFA dietary portfolio (15·9% between-diet difference, P¼0·03). This difference appeared to be mainly attributable to a reduction in apoAI fractional catabolic rate (FCR) after the high-MUFA diet (25·6%, P¼0·02 v. pre-diet values), with no significant change in production rate. The high-MUFA dietary portfolio tended to reduce LDL apoB100 PS compared with the low-MUFA dietary portfolio (228·5% between-diet that adding MUFA to a dietary portfolio of cholesterol-lowering foods provides the added advantage of raising HDL primarily through a reduction in HDL clearance rate. Replacing CHO with MUFA in a dietary portfolio may also lead to reductions in LDL apoB100 concentrations primarily by increasing LDL clearance rate, thus potentiating further the well-known cholesterol-lowering effect of this diet.

Authors+Show Affiliations

Institute of Nutraceuticals and Functional Foods, Laval University, 2440, Boulevard Hochelaga, Québec, QC, Canada G1V 0A6.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23312076

Citation

Labonté, Marie-Ève, et al. "Adding MUFA to a Dietary Portfolio of Cholesterol-lowering Foods Reduces apoAI Fractional Catabolic Rate in Subjects With Dyslipidaemia." The British Journal of Nutrition, vol. 110, no. 3, 2013, pp. 426-36.
Labonté MÈ, Jenkins DJ, Lewis GF, et al. Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia. Br J Nutr. 2013;110(3):426-36.
Labonté, M. È., Jenkins, D. J., Lewis, G. F., Chiavaroli, L., Wong, J. M., Kendall, C. W., Hogue, J. C., Couture, P., & Lamarche, B. (2013). Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia. The British Journal of Nutrition, 110(3), 426-36. https://doi.org/10.1017/S000711451200534X
Labonté MÈ, et al. Adding MUFA to a Dietary Portfolio of Cholesterol-lowering Foods Reduces apoAI Fractional Catabolic Rate in Subjects With Dyslipidaemia. Br J Nutr. 2013 Aug 28;110(3):426-36. PubMed PMID: 23312076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adding MUFA to a dietary portfolio of cholesterol-lowering foods reduces apoAI fractional catabolic rate in subjects with dyslipidaemia. AU - Labonté,Marie-Ève, AU - Jenkins,David J A, AU - Lewis,Gary F, AU - Chiavaroli,Laura, AU - Wong,Julia M W, AU - Kendall,Cyril W C, AU - Hogue,Jean-Charles, AU - Couture,Patrick, AU - Lamarche,Benoît, Y1 - 2013/01/14/ PY - 2013/1/15/entrez PY - 2013/1/15/pubmed PY - 2013/9/26/medline SP - 426 EP - 36 JF - The British journal of nutrition JO - Br J Nutr VL - 110 IS - 3 N2 - The present randomised parallel study assessed the impact of adding MUFA to a dietary portfolio of cholesterol-lowering foods on the intravascular kinetics of apoAI- and apoB-containing lipoproteins in subjects with dyslipidaemia. A sample of sixteen men and postmenopausal women consumed a run-in stabilisation diet for 4 weeks. Subjects were then randomly assigned to an experimental dietary portfolio either high or low in MUFA for another 4 weeks. MUFA substituted 13·0% of total energy from carbohydrate (CHO) in the high-MUFA dietary portfolio. Lipoprotein kinetics were assessed after the run-in and portfolio diets using a primed, constant infusion of [2H3]leucine and multicompartmental modelling. The high-MUFA dietary portfolio resulted in higher apoAI pool size (PS) compared with the low-MUFA dietary portfolio (15·9% between-diet difference, P¼0·03). This difference appeared to be mainly attributable to a reduction in apoAI fractional catabolic rate (FCR) after the high-MUFA diet (25·6%, P¼0·02 v. pre-diet values), with no significant change in production rate. The high-MUFA dietary portfolio tended to reduce LDL apoB100 PS compared with the low-MUFA dietary portfolio (228·5% between-diet that adding MUFA to a dietary portfolio of cholesterol-lowering foods provides the added advantage of raising HDL primarily through a reduction in HDL clearance rate. Replacing CHO with MUFA in a dietary portfolio may also lead to reductions in LDL apoB100 concentrations primarily by increasing LDL clearance rate, thus potentiating further the well-known cholesterol-lowering effect of this diet. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/23312076/Adding_MUFA_to_a_dietary_portfolio_of_cholesterol_lowering_foods_reduces_apoAI_fractional_catabolic_rate_in_subjects_with_dyslipidaemia_ L2 - https://www.cambridge.org/core/product/identifier/S000711451200534X/type/journal_article DB - PRIME DP - Unbound Medicine ER -