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Breast cancer subtype approximations and loco-regional recurrence after immediate breast reconstruction.
Eur J Surg Oncol. 2013 Mar; 39(3):260-5.EJ

Abstract

BACKGROUND

A small but significant proportion of patients with breast cancer (BC) will develop loco-regional recurrence (LRR) after immediate breast reconstruction (IBR). The LRR also varies according to breast cancer subtypes and clinicopathological features.

METHODS

We studied 1742 consecutive BC patients with IBR between 1997 and 2006. According to St Gallen conference consensus 2011, its BC approximations were applied to classify BC into five subtypes: estrogen receptor (ER) and/or progesterone receptor (PgR) positive, HER2 negative, and low Ki67 (<14%) [luminal A]; ER and/or PgR positive, HER2 negative and high Ki67(≥ 14%) [luminal B/HER2 negative]; ER and/or PgR positive, any Ki67 and HER2 positive [luminal B/HER2 positive]; ER negative, PgR negative and HER2 positive [HER2 positive/nonluminal]; and ER negative, PgR negative and HER2 negative [triple negative]. Cumulative incidences of LRR were compared across different subgroups by means of the Gray test. Multivariable Cox regression models were applied.

RESULTS

Median follow up time was 74 months (range 3-165). The cumulative incidence of LRR was 5.5% (121 events). The 5-year cumulative incidence of LRR was 2.5% for luminal A; 5.0% for luminal B/HER2 negative; 9.8% for luminal B/HER2 positive; 3.8% for HER2 non luminal; and 10.9% for triple negative. On multivariable analysis, tumor size (pT) >2 cm, body mass index (BMI) ≥ 25, triple negative and luminal B/HER2 positive subtypes were associated with increased risk of LRR.

CONCLUSION

Luminal B/HER2 positive, triple negative subtypes and BMI ≥ 25 are independent prognostic factors for risk of LRR after IBR.

Authors+Show Affiliations

Division of Plastic Reconstruction Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy. mcassilha@ig.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23313014

Citation

Kneubil, M C., et al. "Breast Cancer Subtype Approximations and Loco-regional Recurrence After Immediate Breast Reconstruction." European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 39, no. 3, 2013, pp. 260-5.
Kneubil MC, Brollo J, Botteri E, et al. Breast cancer subtype approximations and loco-regional recurrence after immediate breast reconstruction. Eur J Surg Oncol. 2013;39(3):260-5.
Kneubil, M. C., Brollo, J., Botteri, E., Curigliano, G., Rotmensz, N., Goldhirsch, A., Lohsiriwat, V., Manconi, A., Martella, S., Santillo, B., Petit, J. Y., & Rietjens, M. (2013). Breast cancer subtype approximations and loco-regional recurrence after immediate breast reconstruction. European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 39(3), 260-5. https://doi.org/10.1016/j.ejso.2012.12.004
Kneubil MC, et al. Breast Cancer Subtype Approximations and Loco-regional Recurrence After Immediate Breast Reconstruction. Eur J Surg Oncol. 2013;39(3):260-5. PubMed PMID: 23313014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer subtype approximations and loco-regional recurrence after immediate breast reconstruction. AU - Kneubil,M C, AU - Brollo,J, AU - Botteri,E, AU - Curigliano,G, AU - Rotmensz,N, AU - Goldhirsch,A, AU - Lohsiriwat,V, AU - Manconi,A, AU - Martella,S, AU - Santillo,B, AU - Petit,J Y, AU - Rietjens,M, Y1 - 2013/01/10/ PY - 2012/03/27/received PY - 2012/11/06/revised PY - 2012/12/07/accepted PY - 2013/1/15/entrez PY - 2013/1/15/pubmed PY - 2013/4/6/medline SP - 260 EP - 5 JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JO - Eur J Surg Oncol VL - 39 IS - 3 N2 - BACKGROUND: A small but significant proportion of patients with breast cancer (BC) will develop loco-regional recurrence (LRR) after immediate breast reconstruction (IBR). The LRR also varies according to breast cancer subtypes and clinicopathological features. METHODS: We studied 1742 consecutive BC patients with IBR between 1997 and 2006. According to St Gallen conference consensus 2011, its BC approximations were applied to classify BC into five subtypes: estrogen receptor (ER) and/or progesterone receptor (PgR) positive, HER2 negative, and low Ki67 (<14%) [luminal A]; ER and/or PgR positive, HER2 negative and high Ki67(≥ 14%) [luminal B/HER2 negative]; ER and/or PgR positive, any Ki67 and HER2 positive [luminal B/HER2 positive]; ER negative, PgR negative and HER2 positive [HER2 positive/nonluminal]; and ER negative, PgR negative and HER2 negative [triple negative]. Cumulative incidences of LRR were compared across different subgroups by means of the Gray test. Multivariable Cox regression models were applied. RESULTS: Median follow up time was 74 months (range 3-165). The cumulative incidence of LRR was 5.5% (121 events). The 5-year cumulative incidence of LRR was 2.5% for luminal A; 5.0% for luminal B/HER2 negative; 9.8% for luminal B/HER2 positive; 3.8% for HER2 non luminal; and 10.9% for triple negative. On multivariable analysis, tumor size (pT) >2 cm, body mass index (BMI) ≥ 25, triple negative and luminal B/HER2 positive subtypes were associated with increased risk of LRR. CONCLUSION: Luminal B/HER2 positive, triple negative subtypes and BMI ≥ 25 are independent prognostic factors for risk of LRR after IBR. SN - 1532-2157 UR - https://www.unboundmedicine.com/medline/citation/23313014/Breast_cancer_subtype_approximations_and_loco_regional_recurrence_after_immediate_breast_reconstruction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0748-7983(12)01343-1 DB - PRIME DP - Unbound Medicine ER -