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Malnutrition in early life and adult mental health: evidence from a natural experiment.
Soc Sci Med 2013; 97:259-66SS

Abstract

As natural experiments, famines provide a unique opportunity to test the health consequences of nutritional deprivation during the critical period of early life. Using data on 4972 Chinese born between 1956 and 1963 who participated in a large mental health epidemiology survey conducted between 2001 and 2005, we investigated the potential impact of exposure to the 1959-1961 Chinese Famine in utero and during the early postnatal life on adult mental illness. The risk of mental illness was assessed with the 12-item General Health Questionnaire (GHQ-12) and eight other risk factors, and the famine impact on adult mental illness was estimated by difference-in-difference models. Results show that compared with unexposed women born in 1963, women born during the famine years (1959-1961) had higher GHQ scores (increased by 0.95 points; CI: 0.26, 1.65) and increased risk of mental illness (OR = 2.80; CI: 1.23, 6.39); those born in 1959 were the most affected and had GHQ scores 1.52 points higher (CI: 0.42, 2.63) and an OR for mental illness of 4.99 (CI: 1.68, 14.84). Compared to men in the 1963 birth cohort, men born during the famine had lower GHQ scores (decreased by 0.89 points; CI: -1.59, -0.20) and a nonsignificant decrease in the risk of mental illness (OR = 0.60; CI: 0.26, 1.40). We speculate that the long-term consequences of early-life famine exposure include both the selection of the hardiest and the enduring deleterious effects of famine on those who survive. The greater biological vulnerability and stronger natural selection in utero of male versus female fetuses during severe famine may result in a stronger selection effect among men than women, obscuring the deleterious impact of famine exposure on the risk of mental illness in men later in life.

Authors+Show Affiliations

Department of Global Health, School of Public Health and Health Services, George Washington University, Washington, DC, USA. Electronic address: chenghuang@gwu.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23313495

Citation

Huang, Cheng, et al. "Malnutrition in Early Life and Adult Mental Health: Evidence From a Natural Experiment." Social Science & Medicine (1982), vol. 97, 2013, pp. 259-66.
Huang C, Phillips MR, Zhang Y, et al. Malnutrition in early life and adult mental health: evidence from a natural experiment. Soc Sci Med. 2013;97:259-66.
Huang, C., Phillips, M. R., Zhang, Y., Zhang, J., Shi, Q., Song, Z., ... Martorell, R. (2013). Malnutrition in early life and adult mental health: evidence from a natural experiment. Social Science & Medicine (1982), 97, pp. 259-66. doi:10.1016/j.socscimed.2012.09.051.
Huang C, et al. Malnutrition in Early Life and Adult Mental Health: Evidence From a Natural Experiment. Soc Sci Med. 2013;97:259-66. PubMed PMID: 23313495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Malnutrition in early life and adult mental health: evidence from a natural experiment. AU - Huang,Cheng, AU - Phillips,Michael R, AU - Zhang,Yali, AU - Zhang,Jingxuan, AU - Shi,Qichang, AU - Song,Zhiqiang, AU - Ding,Zhijie, AU - Pang,Shutao, AU - Martorell,Reynaldo, Y1 - 2012/12/20/ PY - 2011/12/19/received PY - 2012/07/21/revised PY - 2012/09/19/accepted PY - 2013/1/15/entrez PY - 2013/1/15/pubmed PY - 2014/2/14/medline KW - China KW - Famine KW - Life course KW - Mental health KW - Natural selection in utero KW - Selection effect SP - 259 EP - 66 JF - Social science & medicine (1982) JO - Soc Sci Med VL - 97 N2 - As natural experiments, famines provide a unique opportunity to test the health consequences of nutritional deprivation during the critical period of early life. Using data on 4972 Chinese born between 1956 and 1963 who participated in a large mental health epidemiology survey conducted between 2001 and 2005, we investigated the potential impact of exposure to the 1959-1961 Chinese Famine in utero and during the early postnatal life on adult mental illness. The risk of mental illness was assessed with the 12-item General Health Questionnaire (GHQ-12) and eight other risk factors, and the famine impact on adult mental illness was estimated by difference-in-difference models. Results show that compared with unexposed women born in 1963, women born during the famine years (1959-1961) had higher GHQ scores (increased by 0.95 points; CI: 0.26, 1.65) and increased risk of mental illness (OR = 2.80; CI: 1.23, 6.39); those born in 1959 were the most affected and had GHQ scores 1.52 points higher (CI: 0.42, 2.63) and an OR for mental illness of 4.99 (CI: 1.68, 14.84). Compared to men in the 1963 birth cohort, men born during the famine had lower GHQ scores (decreased by 0.89 points; CI: -1.59, -0.20) and a nonsignificant decrease in the risk of mental illness (OR = 0.60; CI: 0.26, 1.40). We speculate that the long-term consequences of early-life famine exposure include both the selection of the hardiest and the enduring deleterious effects of famine on those who survive. The greater biological vulnerability and stronger natural selection in utero of male versus female fetuses during severe famine may result in a stronger selection effect among men than women, obscuring the deleterious impact of famine exposure on the risk of mental illness in men later in life. SN - 1873-5347 UR - https://www.unboundmedicine.com/medline/citation/23313495/Malnutrition_in_early_life_and_adult_mental_health:_evidence_from_a_natural_experiment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0277-9536(12)00833-7 DB - PRIME DP - Unbound Medicine ER -