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Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells.
Neurosci Lett. 2013 Feb 22; 535:146-51.NL

Abstract

Acrolein-induced oxidative stress is hypothesized to involve in the etiology of Alzheimer's disease (AD). Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) have antioxidative and neuroprotective properties. The present study investigated the protective effects of CA/CAPE on acrolein-induced oxidative neuronal toxicity. HT22 mouse hippocampal cells were pretreated with CA/CAPE and then exposed to acrolein. Cell viability, intracellular reactive oxygen species (ROS), and glutathione (GSH) level were measured. MAPKs and Akt/GSK3β signaling proteins as well as α/β-secretase of amyloid protein precursor were assayed by Western blotting. Pretreatment with CA/CAPE significantly attenuated acrolein-induced neurotoxicity, ROS accumulation, and GSH depletion. Further study suggested that CA/CAPE showed protective effects against acrolein by modulating MAPKs and Akt/GSK3β signaling pathways. Moreover, CA/CAPE restored the changes of β-secretase (BACE-1) and/or activation of α-secretase (ADAM-10) induced by acrolein. These findings suggest that CA/CAPE may provide a promising approach for the treatment of acrolein-related neurodegenerative diseases, such as AD.

Authors+Show Affiliations

Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23313590

Citation

Huang, Yingjuan, et al. "Protective Effects of Caffeic Acid and Caffeic Acid Phenethyl Ester Against Acrolein-induced Neurotoxicity in HT22 Mouse Hippocampal Cells." Neuroscience Letters, vol. 535, 2013, pp. 146-51.
Huang Y, Jin M, Pi R, et al. Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett. 2013;535:146-51.
Huang, Y., Jin, M., Pi, R., Zhang, J., Chen, M., Ouyang, Y., Liu, A., Chao, X., Liu, P., Liu, J., Ramassamy, C., & Qin, J. (2013). Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neuroscience Letters, 535, 146-51. https://doi.org/10.1016/j.neulet.2012.12.051
Huang Y, et al. Protective Effects of Caffeic Acid and Caffeic Acid Phenethyl Ester Against Acrolein-induced Neurotoxicity in HT22 Mouse Hippocampal Cells. Neurosci Lett. 2013 Feb 22;535:146-51. PubMed PMID: 23313590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. AU - Huang,Yingjuan, AU - Jin,Minghua, AU - Pi,Rongbiao, AU - Zhang,Junjie, AU - Chen,Meihui, AU - Ouyang,Ying, AU - Liu,Anmin, AU - Chao,Xiaojuan, AU - Liu,Peiqing, AU - Liu,Jun, AU - Ramassamy,Charles, AU - Qin,Jian, Y1 - 2013/01/08/ PY - 2012/11/22/received PY - 2012/12/18/revised PY - 2012/12/21/accepted PY - 2013/1/15/entrez PY - 2013/1/15/pubmed PY - 2013/6/26/medline SP - 146 EP - 51 JF - Neuroscience letters JO - Neurosci Lett VL - 535 N2 - Acrolein-induced oxidative stress is hypothesized to involve in the etiology of Alzheimer's disease (AD). Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) have antioxidative and neuroprotective properties. The present study investigated the protective effects of CA/CAPE on acrolein-induced oxidative neuronal toxicity. HT22 mouse hippocampal cells were pretreated with CA/CAPE and then exposed to acrolein. Cell viability, intracellular reactive oxygen species (ROS), and glutathione (GSH) level were measured. MAPKs and Akt/GSK3β signaling proteins as well as α/β-secretase of amyloid protein precursor were assayed by Western blotting. Pretreatment with CA/CAPE significantly attenuated acrolein-induced neurotoxicity, ROS accumulation, and GSH depletion. Further study suggested that CA/CAPE showed protective effects against acrolein by modulating MAPKs and Akt/GSK3β signaling pathways. Moreover, CA/CAPE restored the changes of β-secretase (BACE-1) and/or activation of α-secretase (ADAM-10) induced by acrolein. These findings suggest that CA/CAPE may provide a promising approach for the treatment of acrolein-related neurodegenerative diseases, such as AD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/23313590/Protective_effects_of_caffeic_acid_and_caffeic_acid_phenethyl_ester_against_acrolein_induced_neurotoxicity_in_HT22_mouse_hippocampal_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(13)00011-6 DB - PRIME DP - Unbound Medicine ER -