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Serum vitamin B12 and methylmalonic acid determinations in the diagnosis of cobalt deficiency in pregnant ewes.
Br Vet J. 1990 Mar-Apr; 146(2):120-8.BV

Abstract

Serum vitamin B12 and methylmalonic acid (MMA) concentrations were used to monitor the development of cobalt (Co) deficiency and repletion from the deficient state in housed pregnant hill sheep. Serum MMA concentrations were less variable and provided a more accurate diagnosis of Co deficiency than serum vitamin B12. This was particularly the case for subclinical disease. However, unlike serum MMA, concentrations of the vitamin in serum could be used prognostically. The most precise diagnosis was provided by serum vitamin B12 and MMA data used in conjunction, but where one technique is to be used, serum MMA determinations are preferred.

Authors+Show Affiliations

Fisher GE
West of Scotland College (for Agricultural, Horticultural and Food Studies), Dumfries.
MacPherson A
No affiliation info available

MeSH

AnimalsCobaltFemaleMalonatesMethylmalonic AcidPregnancyPregnancy ComplicationsPrognosisSheepSheep DiseasesVitamin B 12

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2331589

Citation

Fisher, G E., and A MacPherson. "Serum Vitamin B12 and Methylmalonic Acid Determinations in the Diagnosis of Cobalt Deficiency in Pregnant Ewes." The British Veterinary Journal, vol. 146, no. 2, 1990, pp. 120-8.
Fisher GE, MacPherson A. Serum vitamin B12 and methylmalonic acid determinations in the diagnosis of cobalt deficiency in pregnant ewes. Br Vet J. 1990;146(2):120-8.
Fisher, G. E., & MacPherson, A. (1990). Serum vitamin B12 and methylmalonic acid determinations in the diagnosis of cobalt deficiency in pregnant ewes. The British Veterinary Journal, 146(2), 120-8.
Fisher GE, MacPherson A. Serum Vitamin B12 and Methylmalonic Acid Determinations in the Diagnosis of Cobalt Deficiency in Pregnant Ewes. Br Vet J. 1990 Mar-Apr;146(2):120-8. PubMed PMID: 2331589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum vitamin B12 and methylmalonic acid determinations in the diagnosis of cobalt deficiency in pregnant ewes. AU - Fisher,G E, AU - MacPherson,A, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 120 EP - 8 JF - The British veterinary journal JO - Br Vet J VL - 146 IS - 2 N2 - Serum vitamin B12 and methylmalonic acid (MMA) concentrations were used to monitor the development of cobalt (Co) deficiency and repletion from the deficient state in housed pregnant hill sheep. Serum MMA concentrations were less variable and provided a more accurate diagnosis of Co deficiency than serum vitamin B12. This was particularly the case for subclinical disease. However, unlike serum MMA, concentrations of the vitamin in serum could be used prognostically. The most precise diagnosis was provided by serum vitamin B12 and MMA data used in conjunction, but where one technique is to be used, serum MMA determinations are preferred. SN - 0007-1935 UR - https://www.unboundmedicine.com/medline/citation/2331589/Serum_vitamin_B12_and_methylmalonic_acid_determinations_in_the_diagnosis_of_cobalt_deficiency_in_pregnant_ewes_ DB - PRIME DP - Unbound Medicine ER -