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Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats.
Toxicon. 2013 Mar 15; 64:81-6.T

Abstract

Ciguatoxins are sodium channel activator toxins responsible for ciguatera fish poisoning. In this study, we determined the toxicokinetic parameters of the Pacific ciguatoxin P-CTX-1 in rats after an intravenous (iv) dose of 0.13 ng P-CTX-1 per g of body weight. The ciguatoxin activity was assessed over time in blood using the sensitive functional Neuro2a assay. The data were analyzed with a two-compartmental model. After exposure, the ciguatoxin activity exhibited a rapid (alpha half-life of 6 min) and extensive distribution into tissues (apparent steady state volume of distribution of 7.8 L). Ciguatoxin elimination from blood was slower with a beta half-life estimated at 35.5 h. The toxicokinetic parameters determined from this study were compared to data previously obtained after oral and intraperitoneal exposure of rats to 0.26 ng P-CTX-1 per g of body weight. Maximal bioavailability was determined by the area under the concentration curve, and was used to calculate the absolute P-CTX-1 bioavailabilities for oral and intraperitoneal routes of exposures of 39% and 75%, respectively.

Authors+Show Affiliations

Marine Biotoxins Program, Center for Coastal Environmental Health and Biomolecular Research, NOAA - National Ocean Service, 219 Fort Johnson Road, Charleston, SC 29412, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23319077

Citation

Ledreux, Aurélie, and John S. Ramsdell. "Bioavailability and Intravenous Toxicokinetic Parameters for Pacific Ciguatoxin P-CTX-1 in Rats." Toxicon : Official Journal of the International Society On Toxinology, vol. 64, 2013, pp. 81-6.
Ledreux A, Ramsdell JS. Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. Toxicon. 2013;64:81-6.
Ledreux, A., & Ramsdell, J. S. (2013). Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. Toxicon : Official Journal of the International Society On Toxinology, 64, 81-6. https://doi.org/10.1016/j.toxicon.2012.12.026
Ledreux A, Ramsdell JS. Bioavailability and Intravenous Toxicokinetic Parameters for Pacific Ciguatoxin P-CTX-1 in Rats. Toxicon. 2013 Mar 15;64:81-6. PubMed PMID: 23319077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability and intravenous toxicokinetic parameters for Pacific ciguatoxin P-CTX-1 in rats. AU - Ledreux,Aurélie, AU - Ramsdell,John S, Y1 - 2013/01/11/ PY - 2012/08/21/received PY - 2012/12/26/revised PY - 2012/12/30/accepted PY - 2013/1/16/entrez PY - 2013/1/16/pubmed PY - 2013/7/24/medline SP - 81 EP - 6 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 64 N2 - Ciguatoxins are sodium channel activator toxins responsible for ciguatera fish poisoning. In this study, we determined the toxicokinetic parameters of the Pacific ciguatoxin P-CTX-1 in rats after an intravenous (iv) dose of 0.13 ng P-CTX-1 per g of body weight. The ciguatoxin activity was assessed over time in blood using the sensitive functional Neuro2a assay. The data were analyzed with a two-compartmental model. After exposure, the ciguatoxin activity exhibited a rapid (alpha half-life of 6 min) and extensive distribution into tissues (apparent steady state volume of distribution of 7.8 L). Ciguatoxin elimination from blood was slower with a beta half-life estimated at 35.5 h. The toxicokinetic parameters determined from this study were compared to data previously obtained after oral and intraperitoneal exposure of rats to 0.26 ng P-CTX-1 per g of body weight. Maximal bioavailability was determined by the area under the concentration curve, and was used to calculate the absolute P-CTX-1 bioavailabilities for oral and intraperitoneal routes of exposures of 39% and 75%, respectively. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/23319077/Bioavailability_and_intravenous_toxicokinetic_parameters_for_Pacific_ciguatoxin_P_CTX_1_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(13)00011-1 DB - PRIME DP - Unbound Medicine ER -