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Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome.

Abstract

Insulin resistance is a very common associate of polycystic ovary syndrome (PCOS). Pathophysiology in relation with the essential elements including copper, magnesium, zinc, manganese, chromium, and calcium has been reported in women with insulin resistance. This prospective study was designed to explore whether the women with PCOS do exhibit altered serum element levels in association with/without insulin resistance. One hundred and thirty-two women with PCOS and forty-six control women were studied. Women with PCOS were further divided based on the presence of insulin resistance (insulin resistant: n = 50; non-insulin resistant: n = 82). In all women, basal levels of gonadotropins, prolactin, testosterone, insulin, glucose, and the six different elements were measured. Serum levels of testosterone (p < 0.001), luteinizing hormone (p < 0.05), and fasting insulin (p < 0.004) were significantly higher in the PCOS population compared to controls as well as PCOS women without insulin resistance. Women with PCOS exhibited a significantly high calcium (p < 0.04) and lower manganese levels (p < 0.002) when compared to controls. However, the PCOS women with insulin resistance exhibited significantly lower serum levels of magnesium and chromium (p < 0.04), in addition to higher levels of zinc and copper (p < 0.04). The differences in calcium (p < 0.03) and manganese levels (p < 0.0001) became aggravated with the presence of insulin resistance when compared to control as well as PCOS women without insulin resistance. In PCOS-associated insulin resistance, circulating serum magnesium (r = -0.31; p < 0.03) and chromium (r = -0.38; p < 0.006) status significantly correlated with fasting insulin levels. We conclude that imbalanced element status may be a key foundation for insulin resistance in PCOS. The findings in this study should be investigated with further trials in order to obtain new insights into PCOS.

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  • Authors+Show Affiliations

    ,

    Department of Infertility, Institute of Reproductive Medicine, Salt Lake City, Kolkata 700106, India.

    , , , ,

    Source

    Biological trace element research 152:1 2013 Apr pg 9-15

    MeSH

    Adult
    Blood Glucose
    Calcium
    Chromium
    Copper
    Fasting
    Female
    Gonadotropins
    Humans
    Insulin
    Insulin Resistance
    Luteinizing Hormone
    Magnesium
    Manganese
    Polycystic Ovary Syndrome
    Prolactin
    Prospective Studies
    Testosterone
    Trace Elements
    Zinc

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    23322284

    Citation

    Chakraborty, Pratip, et al. "Altered Trace Mineral Milieu Might Play an Aetiological Role in the Pathogenesis of Polycystic Ovary Syndrome." Biological Trace Element Research, vol. 152, no. 1, 2013, pp. 9-15.
    Chakraborty P, Ghosh S, Goswami SK, et al. Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. Biol Trace Elem Res. 2013;152(1):9-15.
    Chakraborty, P., Ghosh, S., Goswami, S. K., Kabir, S. N., Chakravarty, B., & Jana, K. (2013). Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. Biological Trace Element Research, 152(1), pp. 9-15. doi:10.1007/s12011-012-9592-5.
    Chakraborty P, et al. Altered Trace Mineral Milieu Might Play an Aetiological Role in the Pathogenesis of Polycystic Ovary Syndrome. Biol Trace Elem Res. 2013;152(1):9-15. PubMed PMID: 23322284.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. AU - Chakraborty,Pratip, AU - Ghosh,Sanghamitra, AU - Goswami,S K, AU - Kabir,Syed N, AU - Chakravarty,Baidyanath, AU - Jana,Kuladip, Y1 - 2013/01/16/ PY - 2012/09/24/received PY - 2012/12/21/accepted PY - 2013/1/17/entrez PY - 2013/1/17/pubmed PY - 2013/8/30/medline SP - 9 EP - 15 JF - Biological trace element research JO - Biol Trace Elem Res VL - 152 IS - 1 N2 - Insulin resistance is a very common associate of polycystic ovary syndrome (PCOS). Pathophysiology in relation with the essential elements including copper, magnesium, zinc, manganese, chromium, and calcium has been reported in women with insulin resistance. This prospective study was designed to explore whether the women with PCOS do exhibit altered serum element levels in association with/without insulin resistance. One hundred and thirty-two women with PCOS and forty-six control women were studied. Women with PCOS were further divided based on the presence of insulin resistance (insulin resistant: n = 50; non-insulin resistant: n = 82). In all women, basal levels of gonadotropins, prolactin, testosterone, insulin, glucose, and the six different elements were measured. Serum levels of testosterone (p < 0.001), luteinizing hormone (p < 0.05), and fasting insulin (p < 0.004) were significantly higher in the PCOS population compared to controls as well as PCOS women without insulin resistance. Women with PCOS exhibited a significantly high calcium (p < 0.04) and lower manganese levels (p < 0.002) when compared to controls. However, the PCOS women with insulin resistance exhibited significantly lower serum levels of magnesium and chromium (p < 0.04), in addition to higher levels of zinc and copper (p < 0.04). The differences in calcium (p < 0.03) and manganese levels (p < 0.0001) became aggravated with the presence of insulin resistance when compared to control as well as PCOS women without insulin resistance. In PCOS-associated insulin resistance, circulating serum magnesium (r = -0.31; p < 0.03) and chromium (r = -0.38; p < 0.006) status significantly correlated with fasting insulin levels. We conclude that imbalanced element status may be a key foundation for insulin resistance in PCOS. The findings in this study should be investigated with further trials in order to obtain new insights into PCOS. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/23322284/Altered_trace_mineral_milieu_might_play_an_aetiological_role_in_the_pathogenesis_of_polycystic_ovary_syndrome_ L2 - https://dx.doi.org/10.1007/s12011-012-9592-5 DB - PRIME DP - Unbound Medicine ER -