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Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus.
mBio. 2013 Jan 15; 4(1)MBIO

Abstract

A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.

Authors+Show Affiliations

Department of Microbiology, University of Iowa, Iowa City, Iowa, USA.No affiliation info available

Pub Type(s)

Journal Article
Comment

Language

eng

PubMed ID

23322635

Citation

Perlman, Stanley, and Jincun Zhao. "Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus." MBio, vol. 4, no. 1, 2013.
Perlman S, Zhao J. Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus. mBio. 2013;4(1).
Perlman, S., & Zhao, J. (2013). Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus. MBio, 4(1). https://doi.org/10.1128/mBio.00002-13
Perlman S, Zhao J. Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus. mBio. 2013 Jan 15;4(1) PubMed PMID: 23322635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human coronavirus EMC is not the same as severe acute respiratory syndrome coronavirus. AU - Perlman,Stanley, AU - Zhao,Jincun, Y1 - 2013/01/15/ PY - 2013/1/17/entrez PY - 2013/1/17/pubmed PY - 2013/6/12/medline JF - mBio JO - mBio VL - 4 IS - 1 N2 - A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions. SN - 2150-7511 UR - https://www.unboundmedicine.com/medline/citation/23322635/Human_coronavirus_EMC_is_not_the_same_as_severe_acute_respiratory_syndrome_coronavirus_ L2 - http://mbio.asm.org/cgi/pmidlookup?view=long&pmid=23322635 DB - PRIME DP - Unbound Medicine ER -
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