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The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms.
Am J Alzheimers Dis Other Demen. 2013 Mar; 28(2):126-36.AJ

Abstract

Alzheimer's disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive memory loss and cognitive dysfunction. A significant association between AD and low levels of vitamin D has been demonstrated. Furthermore, vitamin D supplements appear to have a beneficial clinical effect on AD by regulating micro-RNA, enhancing toll-like receptors, modulating vascular endothelial factor expression, modulating angiogenin, and advanced glycation end products. Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-β peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression. In conclusion, vitamin D may play a beneficial role in AD. Calcitriol is the best vitamin D supplement for AD, because it is the active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Therefore, further investigation of the role of calcitriol in AD is needed.

Authors+Show Affiliations

Vietnamese American Medical Research Foundation, 14971 Brookhurst St. Westminster, CA 92683, USA. Lng2687765@aol.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

23322908

Citation

Lu'o'ng, Khanh Vinh Quoc, and Lan Thi Hoàng Nguyen. "The Role of Vitamin D in Alzheimer's Disease: Possible Genetic and Cell Signaling Mechanisms." American Journal of Alzheimer's Disease and Other Dementias, vol. 28, no. 2, 2013, pp. 126-36.
Lu'o'ng KV, Nguyen LT. The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms. Am J Alzheimers Dis Other Demen. 2013;28(2):126-36.
Lu'o'ng, K. V., & Nguyen, L. T. (2013). The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms. American Journal of Alzheimer's Disease and Other Dementias, 28(2), 126-36. https://doi.org/10.1177/1533317512473196
Lu'o'ng KV, Nguyen LT. The Role of Vitamin D in Alzheimer's Disease: Possible Genetic and Cell Signaling Mechanisms. Am J Alzheimers Dis Other Demen. 2013;28(2):126-36. PubMed PMID: 23322908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of vitamin D in Alzheimer's disease: possible genetic and cell signaling mechanisms. AU - Lu'o'ng,Khanh Vinh Quoc, AU - Nguyen,Lan Thi Hoàng, Y1 - 2013/01/15/ PY - 2013/1/17/entrez PY - 2013/1/17/pubmed PY - 2013/9/4/medline SP - 126 EP - 36 JF - American journal of Alzheimer's disease and other dementias JO - Am J Alzheimers Dis Other Demen VL - 28 IS - 2 N2 - Alzheimer's disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive memory loss and cognitive dysfunction. A significant association between AD and low levels of vitamin D has been demonstrated. Furthermore, vitamin D supplements appear to have a beneficial clinical effect on AD by regulating micro-RNA, enhancing toll-like receptors, modulating vascular endothelial factor expression, modulating angiogenin, and advanced glycation end products. Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-β peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression. In conclusion, vitamin D may play a beneficial role in AD. Calcitriol is the best vitamin D supplement for AD, because it is the active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Therefore, further investigation of the role of calcitriol in AD is needed. SN - 1938-2731 UR - https://www.unboundmedicine.com/medline/citation/23322908/The_role_of_vitamin_D_in_Alzheimer's_disease:_possible_genetic_and_cell_signaling_mechanisms_ DB - PRIME DP - Unbound Medicine ER -