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The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study.
BMC Nephrol. 2013 Jan 16; 14:15.BN

Abstract

BACKGROUND

There are no prior studies that have estimated the risk of upper gastrointestinal bleeding (UGIB) among the dialysis population relative to the general population. The aim of this study was to examine the risk of UGIB among end-stage renal disease (ESRD) patients during a 6-year period following their initiation of hemodialysis (HD) therapy in Taiwan- a country with the highest incidence of ESRD in the world, using general population as an external comparison group.

METHODS

Data were obtained from the Taiwan National health Insurance Research Database. In total, 796 patients who were beginning HD between 1999 and 2003 were recruited as the study cohort and 3,184 patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression models were used to adjust for confounding and to compare the 6-year UGIB-free survival rate between these two cohorts.

RESULTS

The incidence rate of UGIB (42.01 per 1000 person-year) was significantly higher in the HD cohort than in the control cohort (27.39 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios for UGIB during the 6-year follow-up periods for HD patients was 1.27 (95% CI=1.03-1.57) compared to patients in the comparison cohort.

CONCLUSIONS

We conclude that HD patients were at an increased risk for UGIB compared with the general population.

Authors+Show Affiliations

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang-Gung Memorial Hospital and Chang-Gung University College of Medicine, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23324652

Citation

Kuo, Chien-Chun, et al. "The Risk of Upper Gastrointestinal Bleeding in Patients Treated With Hemodialysis: a Population-based Cohort Study." BMC Nephrology, vol. 14, 2013, p. 15.
Kuo CC, Kuo HW, Lee IM, et al. The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study. BMC Nephrol. 2013;14:15.
Kuo, C. C., Kuo, H. W., Lee, I. M., Lee, C. T., & Yang, C. Y. (2013). The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study. BMC Nephrology, 14, 15. https://doi.org/10.1186/1471-2369-14-15
Kuo CC, et al. The Risk of Upper Gastrointestinal Bleeding in Patients Treated With Hemodialysis: a Population-based Cohort Study. BMC Nephrol. 2013 Jan 16;14:15. PubMed PMID: 23324652.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The risk of upper gastrointestinal bleeding in patients treated with hemodialysis: a population-based cohort study. AU - Kuo,Chien-Chun, AU - Kuo,Hsin-Wei, AU - Lee,I-Ming, AU - Lee,Chien-Te, AU - Yang,Chun-Yuh, Y1 - 2013/01/16/ PY - 2012/07/01/received PY - 2013/01/14/accepted PY - 2013/1/18/entrez PY - 2013/1/18/pubmed PY - 2013/7/13/medline SP - 15 EP - 15 JF - BMC nephrology JO - BMC Nephrol VL - 14 N2 - BACKGROUND: There are no prior studies that have estimated the risk of upper gastrointestinal bleeding (UGIB) among the dialysis population relative to the general population. The aim of this study was to examine the risk of UGIB among end-stage renal disease (ESRD) patients during a 6-year period following their initiation of hemodialysis (HD) therapy in Taiwan- a country with the highest incidence of ESRD in the world, using general population as an external comparison group. METHODS: Data were obtained from the Taiwan National health Insurance Research Database. In total, 796 patients who were beginning HD between 1999 and 2003 were recruited as the study cohort and 3,184 patients matched for age and sex were included as comparison cohort. Multivariate Cox proportional hazard regression models were used to adjust for confounding and to compare the 6-year UGIB-free survival rate between these two cohorts. RESULTS: The incidence rate of UGIB (42.01 per 1000 person-year) was significantly higher in the HD cohort than in the control cohort (27.39 per 1000 person-years). After adjusting for potential confounders, the adjusted hazard ratios for UGIB during the 6-year follow-up periods for HD patients was 1.27 (95% CI=1.03-1.57) compared to patients in the comparison cohort. CONCLUSIONS: We conclude that HD patients were at an increased risk for UGIB compared with the general population. SN - 1471-2369 UR - https://www.unboundmedicine.com/medline/citation/23324652/The_risk_of_upper_gastrointestinal_bleeding_in_patients_treated_with_hemodialysis:_a_population_based_cohort_study_ L2 - https://www.biomedcentral.com/1471-2369/14/15 DB - PRIME DP - Unbound Medicine ER -