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Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay.
J Infect Dev Ctries 2013; 7(1):10-6JI

Abstract

INTRODUCTION

Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario "Pereira Rossell" (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced.

METHODOLOGY

One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied.

RESULTS

CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found.

CONCLUSIONS

CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes.

Authors+Show Affiliations

Departamento de Bacteriología y Virología-Instituto de Higiene. Universidad de la República, Uruguay. lpardo@higiene.edu.uy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23324815

Citation

Pardo, Lorena, et al. "Community-associated Methicillin-resistant Staphylococcus Aureus in Children Treated in Uruguay." Journal of Infection in Developing Countries, vol. 7, no. 1, 2013, pp. 10-6.
Pardo L, Vola M, Macedo-Viñas M, et al. Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay. J Infect Dev Ctries. 2013;7(1):10-6.
Pardo, L., Vola, M., Macedo-Viñas, M., Machado, V., Cuello, D., Mollerach, M., ... Algorta, G. (2013). Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay. Journal of Infection in Developing Countries, 7(1), pp. 10-6. doi:10.3855/jidc.2261.
Pardo L, et al. Community-associated Methicillin-resistant Staphylococcus Aureus in Children Treated in Uruguay. J Infect Dev Ctries. 2013 Jan 15;7(1):10-6. PubMed PMID: 23324815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay. AU - Pardo,Lorena, AU - Vola,Magdalena, AU - Macedo-Viñas,Marina, AU - Machado,Virginia, AU - Cuello,Dianna, AU - Mollerach,Marta, AU - Castro,Marta, AU - Pírez,Catalina, AU - Varela,Gustavo, AU - Algorta,Gabriela, Y1 - 2013/01/15/ PY - 2011/08/18/received PY - 2012/04/05/accepted PY - 2012/03/10/revised PY - 2013/1/18/entrez PY - 2013/1/18/pubmed PY - 2013/6/28/medline SP - 10 EP - 6 JF - Journal of infection in developing countries JO - J Infect Dev Ctries VL - 7 IS - 1 N2 - INTRODUCTION: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario "Pereira Rossell" (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. METHODOLOGY: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. RESULTS: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim-sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. CONCLUSIONS: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes. SN - 1972-2680 UR - https://www.unboundmedicine.com/medline/citation/23324815/Community_associated_methicillin_resistant_Staphylococcus_aureus_in_children_treated_in_Uruguay_ L2 - http://www.jidc.org/index.php/journal/article/view/23324815 DB - PRIME DP - Unbound Medicine ER -