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Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease.
J Cardiovasc Pharmacol Ther. 2013 Jul; 18(4):320-6.JC

Abstract

BACKGROUND

A low n-3 to n-6 polyunsaturated fatty acids (PUFAs) ratio is reported to be associated with cardiovascular events. However, the effects of statins on this ratio have not been fully examined.

METHODS

A total of 101 patients with coronary artery disease, who were not receiving lipid-lowering therapy were randomly assigned to receive either 4 mg/day of pitavastatin or 20 mg/day of pravastatin. Serum PUFA levels were measured at baseline and 8 months after treatment with statins.

RESULTS

Pitavastatin was used to treat 51 patients and the remaining 50 patients were treated using pravastatin. A significant positive correlation was observed between the percent change in low-density lipoprotein cholesterol and that in dihomogamma-linolenic acid (r = .376, P = .007), arachidonic acid (AA; r = .316, P = .02), eicosapentaenoic acid (EPA; r = .408, P = .003), or docosahexaenoic acid (DHA; r = .270, P = .056) in the pitavastatin group. However, these correlations were not observed in the pravastatin group. The DHA/AA ratio decreased significantly in the pitavastatin group only (from 0.96 to 0.83, P = .0002) and the DHA/AA ratio was significantly lower in the pitavastatin group at 8 months (0.83 vs 0.96, P = .03). The EPA/AA ratio did not show significant changes in either group.

CONCLUSIONS

Pitavastatin decreased the serum DHA/AA ratio, whereas pravastatin had no effect on this ratio. Neither pitavastatin nor pravastatin had an effect on the serum EPA/AA ratio in patients with coronary artery disease.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan. nozue2493@yahoo.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

23324995

Citation

Nozue, Tsuyoshi, et al. "Effects of Statins On Serum N-3 to N-6 Polyunsaturated Fatty Acid Ratios in Patients With Coronary Artery Disease." Journal of Cardiovascular Pharmacology and Therapeutics, vol. 18, no. 4, 2013, pp. 320-6.
Nozue T, Yamamoto S, Tohyama S, et al. Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. J Cardiovasc Pharmacol Ther. 2013;18(4):320-6.
Nozue, T., Yamamoto, S., Tohyama, S., Fukui, K., Umezawa, S., Onishi, Y., Kunishima, T., Sato, A., Nozato, T., Miyake, S., Takeyama, Y., Morino, Y., Yamauchi, T., Muramatsu, T., Hibi, K., & Michishita, I. (2013). Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. Journal of Cardiovascular Pharmacology and Therapeutics, 18(4), 320-6. https://doi.org/10.1177/1074248412473202
Nozue T, et al. Effects of Statins On Serum N-3 to N-6 Polyunsaturated Fatty Acid Ratios in Patients With Coronary Artery Disease. J Cardiovasc Pharmacol Ther. 2013;18(4):320-6. PubMed PMID: 23324995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease. AU - Nozue,Tsuyoshi, AU - Yamamoto,Shingo, AU - Tohyama,Shinichi, AU - Fukui,Kazuki, AU - Umezawa,Shigeo, AU - Onishi,Yuko, AU - Kunishima,Tomoyuki, AU - Sato,Akira, AU - Nozato,Toshihiro, AU - Miyake,Shogo, AU - Takeyama,Youichi, AU - Morino,Yoshihiro, AU - Yamauchi,Takao, AU - Muramatsu,Toshiya, AU - Hibi,Kiyoshi, AU - Michishita,Ichiro, Y1 - 2013/01/15/ PY - 2013/1/18/entrez PY - 2013/1/18/pubmed PY - 2013/10/23/medline KW - coronary artery disease KW - polyunsaturated fatty acids KW - statin SP - 320 EP - 6 JF - Journal of cardiovascular pharmacology and therapeutics JO - J. Cardiovasc. Pharmacol. Ther. VL - 18 IS - 4 N2 - BACKGROUND: A low n-3 to n-6 polyunsaturated fatty acids (PUFAs) ratio is reported to be associated with cardiovascular events. However, the effects of statins on this ratio have not been fully examined. METHODS: A total of 101 patients with coronary artery disease, who were not receiving lipid-lowering therapy were randomly assigned to receive either 4 mg/day of pitavastatin or 20 mg/day of pravastatin. Serum PUFA levels were measured at baseline and 8 months after treatment with statins. RESULTS: Pitavastatin was used to treat 51 patients and the remaining 50 patients were treated using pravastatin. A significant positive correlation was observed between the percent change in low-density lipoprotein cholesterol and that in dihomogamma-linolenic acid (r = .376, P = .007), arachidonic acid (AA; r = .316, P = .02), eicosapentaenoic acid (EPA; r = .408, P = .003), or docosahexaenoic acid (DHA; r = .270, P = .056) in the pitavastatin group. However, these correlations were not observed in the pravastatin group. The DHA/AA ratio decreased significantly in the pitavastatin group only (from 0.96 to 0.83, P = .0002) and the DHA/AA ratio was significantly lower in the pitavastatin group at 8 months (0.83 vs 0.96, P = .03). The EPA/AA ratio did not show significant changes in either group. CONCLUSIONS: Pitavastatin decreased the serum DHA/AA ratio, whereas pravastatin had no effect on this ratio. Neither pitavastatin nor pravastatin had an effect on the serum EPA/AA ratio in patients with coronary artery disease. SN - 1940-4034 UR - https://www.unboundmedicine.com/medline/citation/23324995/Effects_of_statins_on_serum_n_3_to_n_6_polyunsaturated_fatty_acid_ratios_in_patients_with_coronary_artery_disease_ L2 - http://journals.sagepub.com/doi/full/10.1177/1074248412473202?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -