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The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis.
PLoS One. 2013; 8(1):e53558.Plos

Abstract

BACKGROUND

A number of studies assessed the association of tissue plasminogen activator(TPA) gene polymorphisms with ischemic stroke, but the results were contradictory. We aimed to explore the role of TPA -7351C/T SNP in the susceptibility to ischemic stroke through a meta-analysis.

METHODS

The PubMed, MEDLINE, EMBASE, China Biological Medicine Database and WANFANG DATA databases were searched until August 2012. The strict selection criteria and exclusion criteria were determined, and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Stroke subtype was determined using Trial of Org 10172 in Acute Treatment criteria (TOAST). Statistical analyses were performed using the STATA12.0 software.

RESULTS

A total of 2,299 ischemic stroke cases and 1,948 controls in seven case-control studies were included in the meta-analysis. Significant association between -7351C/T polymorphism in the TPA gene and ischemic stroke was observed in all comparison models (TT+CT versus CC, TT versus CT+CC and T versus C). In the subgroup analysis by ethnicity, TT homozygote carriers had a 142% increased risk of ischemic stroke compared with the C allele carriers among East-Asians (TT versus CT+CC: OR = 2.42, 95% CI = 1.07-5.48), but not in South-Asians and Caucasians, and significantly increased risks were found for T versus C among both East-Asians (OR = 1.33, 95% CI = 1.05-1.68) and Caucasians(OR = 1.16, 95% CI = 1.02-1.31). Further stratification for stroke subtype in three Caucasian studies showed the association between -7351C/T polymorphism and Large-artery atherosclerosis (LAA), but not Small-vessel occlusion (SVO) and Cardioembolism (CE).

CONCLUSIONS

This meta-analysis suggested that the -7351C/T polymorphism in TPA gene would be a risk factor for ischemic stroke, especially among East-Asians compared with Caucasians, but not in South-Asians, and it may play a role in the pathogenesis of LAA in Caucasians, but not in SVO and CE.

Authors+Show Affiliations

Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23326456

Citation

Sun, Xunsha, et al. "The -7351C/T Polymorphism in the TPA Gene and Ischemic Stroke Risk: a Meta-analysis." PloS One, vol. 8, no. 1, 2013, pp. e53558.
Sun X, Lai R, Li J, et al. The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis. PLoS One. 2013;8(1):e53558.
Sun, X., Lai, R., Li, J., Luo, M., Wang, Y., & Sheng, W. (2013). The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis. PloS One, 8(1), e53558. https://doi.org/10.1371/journal.pone.0053558
Sun X, et al. The -7351C/T Polymorphism in the TPA Gene and Ischemic Stroke Risk: a Meta-analysis. PLoS One. 2013;8(1):e53558. PubMed PMID: 23326456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The -7351C/T polymorphism in the TPA gene and ischemic stroke risk: a meta-analysis. AU - Sun,Xunsha, AU - Lai,Rong, AU - Li,Jiaoxing, AU - Luo,Man, AU - Wang,Yufang, AU - Sheng,Wenli, Y1 - 2013/01/09/ PY - 2012/08/28/received PY - 2012/11/29/accepted PY - 2013/1/18/entrez PY - 2013/1/18/pubmed PY - 2013/7/3/medline SP - e53558 EP - e53558 JF - PloS one JO - PLoS One VL - 8 IS - 1 N2 - BACKGROUND: A number of studies assessed the association of tissue plasminogen activator(TPA) gene polymorphisms with ischemic stroke, but the results were contradictory. We aimed to explore the role of TPA -7351C/T SNP in the susceptibility to ischemic stroke through a meta-analysis. METHODS: The PubMed, MEDLINE, EMBASE, China Biological Medicine Database and WANFANG DATA databases were searched until August 2012. The strict selection criteria and exclusion criteria were determined, and odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Stroke subtype was determined using Trial of Org 10172 in Acute Treatment criteria (TOAST). Statistical analyses were performed using the STATA12.0 software. RESULTS: A total of 2,299 ischemic stroke cases and 1,948 controls in seven case-control studies were included in the meta-analysis. Significant association between -7351C/T polymorphism in the TPA gene and ischemic stroke was observed in all comparison models (TT+CT versus CC, TT versus CT+CC and T versus C). In the subgroup analysis by ethnicity, TT homozygote carriers had a 142% increased risk of ischemic stroke compared with the C allele carriers among East-Asians (TT versus CT+CC: OR = 2.42, 95% CI = 1.07-5.48), but not in South-Asians and Caucasians, and significantly increased risks were found for T versus C among both East-Asians (OR = 1.33, 95% CI = 1.05-1.68) and Caucasians(OR = 1.16, 95% CI = 1.02-1.31). Further stratification for stroke subtype in three Caucasian studies showed the association between -7351C/T polymorphism and Large-artery atherosclerosis (LAA), but not Small-vessel occlusion (SVO) and Cardioembolism (CE). CONCLUSIONS: This meta-analysis suggested that the -7351C/T polymorphism in TPA gene would be a risk factor for ischemic stroke, especially among East-Asians compared with Caucasians, but not in South-Asians, and it may play a role in the pathogenesis of LAA in Caucasians, but not in SVO and CE. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/23326456/The__7351C/T_polymorphism_in_the_TPA_gene_and_ischemic_stroke_risk:_a_meta_analysis_ L2 - https://dx.plos.org/10.1371/journal.pone.0053558 DB - PRIME DP - Unbound Medicine ER -