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Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study.
J Obes 2012; 2012:102942JO

Abstract

Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n = 242) with the GG genotype had higher BMI (P = 0.009), waist circumference (P = 0.002), hip (P = 0.002), and weight (P = 0.03) than GA or AA carriers (n = 94). They had twice the risk of being overweight (BMI ≥ 25) relative to GA or AA carriers (OR = 2.08, CI = 1.02-4.23, and P = 0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n = 595) with the GG genotype had significantly lower BMI (P = 0.009), hip (P = 0.029), and weight (P = 0.027) than GA or AA carriers (n = 216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27-0.91, and P = 0.024). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men.

Authors+Show Affiliations

Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23326649

Citation

Ma, Xian-Yong, et al. "Association Between BDNF Rs6265 and Obesity in the Boston Puerto Rican Health Study." Journal of Obesity, vol. 2012, 2012, p. 102942.
Ma XY, Qiu WQ, Smith CE, et al. Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. J Obes. 2012;2012:102942.
Ma, X. Y., Qiu, W. Q., Smith, C. E., Parnell, L. D., Jiang, Z. Y., Ordovas, J. M., ... Lai, C. Q. (2012). Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. Journal of Obesity, 2012, p. 102942. doi:10.1155/2012/102942.
Ma XY, et al. Association Between BDNF Rs6265 and Obesity in the Boston Puerto Rican Health Study. J Obes. 2012;2012:102942. PubMed PMID: 23326649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between BDNF rs6265 and obesity in the Boston Puerto Rican Health Study. AU - Ma,Xian-Yong, AU - Qiu,Wei Qiao, AU - Smith,Caren E, AU - Parnell,Laurence D, AU - Jiang,Zong-Yong, AU - Ordovas,Jose M, AU - Tucker,Katherine L, AU - Lai,Chao-Qiang, Y1 - 2012/12/27/ PY - 2012/09/12/received PY - 2012/11/06/revised PY - 2012/11/27/accepted PY - 2013/1/18/entrez PY - 2013/1/18/pubmed PY - 2013/6/1/medline SP - 102942 EP - 102942 JF - Journal of obesity JO - J Obes VL - 2012 N2 - Brain-derived neurotrophic factor (BDNF) has been associated with regulation of body weight and appetite. The goal of this study was to examine the interactions of a functional variant (rs6265) in the BDNF gene with dietary intake for obesity traits in the Boston Puerto Rican Health Study. BDNF rs6265 was genotyped in 1147 Puerto Rican adults and examined for association with obesity-related traits. Men (n = 242) with the GG genotype had higher BMI (P = 0.009), waist circumference (P = 0.002), hip (P = 0.002), and weight (P = 0.03) than GA or AA carriers (n = 94). They had twice the risk of being overweight (BMI ≥ 25) relative to GA or AA carriers (OR = 2.08, CI = 1.02-4.23, and P = 0.043). Interactions between rs6265 and polyunsaturated fatty acids (PUFA) intake were associated with BMI, hip, and weight, and n-3 : n-6 PUFA ratio with waist circumference in men. In contrast, women (n = 595) with the GG genotype had significantly lower BMI (P = 0.009), hip (P = 0.029), and weight (P = 0.027) than GA or AA carriers (n = 216). Women with the GG genotype were 50% less likely to be overweight compared to GA or AA carriers (OR = 0.05, CI = 0.27-0.91, and P = 0.024). In summary, BDNF rs6265 is differentially associated with obesity risk by sex and interacts with PUFA intake influencing obesity traits in Boston Puerto Rican men. SN - 2090-0716 UR - https://www.unboundmedicine.com/medline/citation/23326649/Association_between_BDNF_rs6265_and_obesity_in_the_Boston_Puerto_Rican_Health_Study_ L2 - https://dx.doi.org/10.1155/2012/102942 DB - PRIME DP - Unbound Medicine ER -