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Comparison between betamethasone gel applied over endotracheal tube and ketamine gargle for attenuating postoperative sore throat, cough and hoarseness of voice.
Middle East J Anaesthesiol. 2012 Feb; 21(4):513-9.ME

Abstract

BACKGROUND

Tracheal intubation for general anesthesia often leads to trauma of the airway mucosa resulting in postoperative sore throat, hoarseness of voice and cough. The aim of this study was to evaluate two different methods as regard their efficacy for controlling the postoperative pharyngo-laryngo-tracheal sequelae (sore throat, cough, hoarseness of voice) after general anesthesia with laryngoscopy and tracheal intubation. We compared between the effects of betamethasone gel applied over the endotracheal tube and gargling with ketamine solution in reducing these complications during the first 24 postoperative hours after elective surgical procedures in a prospective randomized controlled single blind clinical trial.

METHODS

Seventy five patients ASA physical status I and II, undergoing elective surgery under general anesthesia using endotracheal intubation were enrolled in this prospective, randomized, single-blind study. Patients were randomly divided into 3 groups of 25 patients each: Group (K): (n: 25) Patients in this group were asked to gargle with ketamine 40 mg in 30 ml saline for 60 seconds as repeated smaller attempts, 5 minutes before induction of anesthesia. Group (B) (n: 25): Endotracheal tubes were lubricated with 0.05% betamethasone gel. Group (C) (n: 25):

CONTROL GROUP

patients did not receive ketamine gargle nor betamethasone gel. The incidence and the severity of Postoperative sore throat, cough, and hoarseness of voice were graded at 0, 2, 4, and 24 h after operation by a blinded investigator.

RESULTS

The incidence and severity of sore throat were significantly lower in group (K) and group (B) than group (C) (p < 0.05) at all time intervals. While there was no significant difference between group (K) and group (B) (p > 0.05). The incidence and severity of cough and hoarseness of voice were significantly lower in group (B) than group (C) and group (k) (p < 0.05) at all time intervals.

CONCLUSION

Gargling with ketamine before induction of anesthesia is comparable with application of 0.05% betamethasone gel over the Endotracheal tubes in decreasing postoperative sore throat. In addition, Betmethasone application decreased the incidence and severity of postoperative cough and hoarsness of voice.

Authors+Show Affiliations

Department of anesthesia and intensive care, Faculty of medecine, Ain Shams university, Cairo, Egypt. ahmed_ramzy73@hotmail.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

23327023

Citation

Shaaban, Ahmad R., and Sahar M. Kamal. "Comparison Between Betamethasone Gel Applied Over Endotracheal Tube and Ketamine Gargle for Attenuating Postoperative Sore Throat, Cough and Hoarseness of Voice." Middle East Journal of Anaesthesiology, vol. 21, no. 4, 2012, pp. 513-9.
Shaaban AR, Kamal SM. Comparison between betamethasone gel applied over endotracheal tube and ketamine gargle for attenuating postoperative sore throat, cough and hoarseness of voice. Middle East J Anaesthesiol. 2012;21(4):513-9.
Shaaban, A. R., & Kamal, S. M. (2012). Comparison between betamethasone gel applied over endotracheal tube and ketamine gargle for attenuating postoperative sore throat, cough and hoarseness of voice. Middle East Journal of Anaesthesiology, 21(4), 513-9.
Shaaban AR, Kamal SM. Comparison Between Betamethasone Gel Applied Over Endotracheal Tube and Ketamine Gargle for Attenuating Postoperative Sore Throat, Cough and Hoarseness of Voice. Middle East J Anaesthesiol. 2012;21(4):513-9. PubMed PMID: 23327023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison between betamethasone gel applied over endotracheal tube and ketamine gargle for attenuating postoperative sore throat, cough and hoarseness of voice. AU - Shaaban,Ahmad R, AU - Kamal,Sahar M, PY - 2013/1/19/entrez PY - 2013/1/19/pubmed PY - 2013/2/19/medline SP - 513 EP - 9 JF - Middle East journal of anaesthesiology JO - Middle East J Anaesthesiol VL - 21 IS - 4 N2 - BACKGROUND: Tracheal intubation for general anesthesia often leads to trauma of the airway mucosa resulting in postoperative sore throat, hoarseness of voice and cough. The aim of this study was to evaluate two different methods as regard their efficacy for controlling the postoperative pharyngo-laryngo-tracheal sequelae (sore throat, cough, hoarseness of voice) after general anesthesia with laryngoscopy and tracheal intubation. We compared between the effects of betamethasone gel applied over the endotracheal tube and gargling with ketamine solution in reducing these complications during the first 24 postoperative hours after elective surgical procedures in a prospective randomized controlled single blind clinical trial. METHODS: Seventy five patients ASA physical status I and II, undergoing elective surgery under general anesthesia using endotracheal intubation were enrolled in this prospective, randomized, single-blind study. Patients were randomly divided into 3 groups of 25 patients each: Group (K): (n: 25) Patients in this group were asked to gargle with ketamine 40 mg in 30 ml saline for 60 seconds as repeated smaller attempts, 5 minutes before induction of anesthesia. Group (B) (n: 25): Endotracheal tubes were lubricated with 0.05% betamethasone gel. Group (C) (n: 25): CONTROL GROUP: patients did not receive ketamine gargle nor betamethasone gel. The incidence and the severity of Postoperative sore throat, cough, and hoarseness of voice were graded at 0, 2, 4, and 24 h after operation by a blinded investigator. RESULTS: The incidence and severity of sore throat were significantly lower in group (K) and group (B) than group (C) (p < 0.05) at all time intervals. While there was no significant difference between group (K) and group (B) (p > 0.05). The incidence and severity of cough and hoarseness of voice were significantly lower in group (B) than group (C) and group (k) (p < 0.05) at all time intervals. CONCLUSION: Gargling with ketamine before induction of anesthesia is comparable with application of 0.05% betamethasone gel over the Endotracheal tubes in decreasing postoperative sore throat. In addition, Betmethasone application decreased the incidence and severity of postoperative cough and hoarsness of voice. SN - 0544-0440 UR - https://www.unboundmedicine.com/medline/citation/23327023/Comparison_between_betamethasone_gel_applied_over_endotracheal_tube_and_ketamine_gargle_for_attenuating_postoperative_sore_throat_cough_and_hoarseness_of_voice_ L2 - https://medlineplus.gov/aftersurgery.html DB - PRIME DP - Unbound Medicine ER -