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Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease.
J Periodontol 2013; 84(11):1627-37JP

Abstract

BACKGROUND

This study is performed to evaluate gingival crevicular fluid (GCF) and serum levels of soluble receptor activator of nuclear factor-κB ligand (sRANKL), interleukin (IL)-17A, IL-17E, IL-17F, IL-17A/F, and osteoprotegerin (OPG) in women with rheumatoid arthritis (RA), osteoporosis (OPR), and those who are systemically healthy (SH), all with periodontal disease.

METHODS

GCF and serum samples were obtained before any periodontal intervention from 17 women with RA, 19 with OPR, and 13 who were SH with periodontitis. Full-mouth clinical periodontal measurements were recorded. sRANKL, OPG, and IL-17 levels were determined by enzyme-linked immunosorbent assay.

RESULTS

Clinical periodontal measurements were similar in the three study groups. Although the total amounts of GCF albumin, OPG, IL-17A, and IL-17A/F were similar in the study groups, there were statistically significant differences in GCF concentrations of sRANKL, OPG, IL-17A, IL-17E, IL-17F, and IL-17A/F. The sRANKL/OPG ratios were significantly higher in the RA group than in the OPR and SH groups (P <0.05). Serum sRANKL, sRANKL/OPG, and IL-17A/IL-17E ratios were significantly higher, whereas OPG concentrations were significantly lower in the RA group compared to other groups (P <0.05). Serum IL-17A concentrations were significantly higher in the RA and OPR groups than in the SH group (P <0.05).

CONCLUSION

Increased inflammatory mediator levels in patients with RA, despite the long-term use of various anti-inflammatory drugs, suggest that these patients may have a propensity to overproduce these inflammatory mediators.

Authors+Show Affiliations

Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23327689

Citation

Gümüş, Pınar, et al. "Gingival Crevicular Fluid, Serum Levels of Receptor Activator of Nuclear factor-κB Ligand, Osteoprotegerin, and Interleukin-17 in Patients With Rheumatoid Arthritis and Osteoporosis and With Periodontal Disease." Journal of Periodontology, vol. 84, no. 11, 2013, pp. 1627-37.
Gümüş P, Buduneli E, Bıyıkoğlu B, et al. Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease. J Periodontol. 2013;84(11):1627-37.
Gümüş, P., Buduneli, E., Bıyıkoğlu, B., Aksu, K., Saraç, F., Nile, C., ... Buduneli, N. (2013). Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease. Journal of Periodontology, 84(11), pp. 1627-37. doi:10.1902/jop.2013.120595.
Gümüş P, et al. Gingival Crevicular Fluid, Serum Levels of Receptor Activator of Nuclear factor-κB Ligand, Osteoprotegerin, and Interleukin-17 in Patients With Rheumatoid Arthritis and Osteoporosis and With Periodontal Disease. J Periodontol. 2013;84(11):1627-37. PubMed PMID: 23327689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gingival crevicular fluid, serum levels of receptor activator of nuclear factor-κB ligand, osteoprotegerin, and interleukin-17 in patients with rheumatoid arthritis and osteoporosis and with periodontal disease. AU - Gümüş,Pınar, AU - Buduneli,Eralp, AU - Bıyıkoğlu,Başak, AU - Aksu,Kenan, AU - Saraç,Fulden, AU - Nile,Christopher, AU - Lappin,David, AU - Buduneli,Nurcan, Y1 - 2013/01/17/ PY - 2013/1/19/entrez PY - 2013/1/19/pubmed PY - 2014/8/30/medline SP - 1627 EP - 37 JF - Journal of periodontology JO - J. Periodontol. VL - 84 IS - 11 N2 - BACKGROUND: This study is performed to evaluate gingival crevicular fluid (GCF) and serum levels of soluble receptor activator of nuclear factor-κB ligand (sRANKL), interleukin (IL)-17A, IL-17E, IL-17F, IL-17A/F, and osteoprotegerin (OPG) in women with rheumatoid arthritis (RA), osteoporosis (OPR), and those who are systemically healthy (SH), all with periodontal disease. METHODS: GCF and serum samples were obtained before any periodontal intervention from 17 women with RA, 19 with OPR, and 13 who were SH with periodontitis. Full-mouth clinical periodontal measurements were recorded. sRANKL, OPG, and IL-17 levels were determined by enzyme-linked immunosorbent assay. RESULTS: Clinical periodontal measurements were similar in the three study groups. Although the total amounts of GCF albumin, OPG, IL-17A, and IL-17A/F were similar in the study groups, there were statistically significant differences in GCF concentrations of sRANKL, OPG, IL-17A, IL-17E, IL-17F, and IL-17A/F. The sRANKL/OPG ratios were significantly higher in the RA group than in the OPR and SH groups (P <0.05). Serum sRANKL, sRANKL/OPG, and IL-17A/IL-17E ratios were significantly higher, whereas OPG concentrations were significantly lower in the RA group compared to other groups (P <0.05). Serum IL-17A concentrations were significantly higher in the RA and OPR groups than in the SH group (P <0.05). CONCLUSION: Increased inflammatory mediator levels in patients with RA, despite the long-term use of various anti-inflammatory drugs, suggest that these patients may have a propensity to overproduce these inflammatory mediators. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/23327689/Gingival_crevicular_fluid_serum_levels_of_receptor_activator_of_nuclear_factor_κB_ligand_osteoprotegerin_and_interleukin_17_in_patients_with_rheumatoid_arthritis_and_osteoporosis_and_with_periodontal_disease_ L2 - https://doi.org/10.1902/jop.2013.120595 DB - PRIME DP - Unbound Medicine ER -