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Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.
J Biol Chem. 2013 Mar 08; 288(10):6968-79.JB

Abstract

The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis. Using muscle-specific SirT1-deficient (KO) mice and a cell culture model of differentiated myotubes, we compared the treatment of resveratrol, an activator of SirT1, with that of exercise in inducing mitochondrial biogenesis. These experiments demonstrated that SirT1 plays a modest role in maintaining basal mitochondrial content and a larger role in preserving mitochondrial function. Furthermore, voluntary exercise and RSV treatment induced mitochondrial biogenesis in a SirT1-independent manner. However, when RSV and exercise were combined, a SirT1-dependent synergistic effect was evident, leading to enhanced translocation of PGC-1α and SirT1 to the nucleus and stimulation of mitochondrial biogenesis. Thus, the magnitude of the effect of RSV on muscle mitochondrial biogenesis is reliant on SirT1, as well as the cellular environment, such as that produced by repeated bouts of exercise.

Authors+Show Affiliations

School of Kinesiology and Health Science, York University, Toronto, Ontario M3J 1P3, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23329826

Citation

Menzies, Keir J., et al. "Sirtuin 1-mediated Effects of Exercise and Resveratrol On Mitochondrial Biogenesis." The Journal of Biological Chemistry, vol. 288, no. 10, 2013, pp. 6968-79.
Menzies KJ, Singh K, Saleem A, et al. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem. 2013;288(10):6968-79.
Menzies, K. J., Singh, K., Saleem, A., & Hood, D. A. (2013). Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. The Journal of Biological Chemistry, 288(10), 6968-79. https://doi.org/10.1074/jbc.M112.431155
Menzies KJ, et al. Sirtuin 1-mediated Effects of Exercise and Resveratrol On Mitochondrial Biogenesis. J Biol Chem. 2013 Mar 8;288(10):6968-79. PubMed PMID: 23329826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. AU - Menzies,Keir J, AU - Singh,Kaustabh, AU - Saleem,Ayesha, AU - Hood,David A, Y1 - 2013/01/17/ PY - 2013/1/19/entrez PY - 2013/1/19/pubmed PY - 2013/5/1/medline SP - 6968 EP - 79 JF - The Journal of biological chemistry JO - J. Biol. Chem. VL - 288 IS - 10 N2 - The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis. Using muscle-specific SirT1-deficient (KO) mice and a cell culture model of differentiated myotubes, we compared the treatment of resveratrol, an activator of SirT1, with that of exercise in inducing mitochondrial biogenesis. These experiments demonstrated that SirT1 plays a modest role in maintaining basal mitochondrial content and a larger role in preserving mitochondrial function. Furthermore, voluntary exercise and RSV treatment induced mitochondrial biogenesis in a SirT1-independent manner. However, when RSV and exercise were combined, a SirT1-dependent synergistic effect was evident, leading to enhanced translocation of PGC-1α and SirT1 to the nucleus and stimulation of mitochondrial biogenesis. Thus, the magnitude of the effect of RSV on muscle mitochondrial biogenesis is reliant on SirT1, as well as the cellular environment, such as that produced by repeated bouts of exercise. SN - 1083-351X UR - https://www.unboundmedicine.com/medline/citation/23329826/Sirtuin_1_mediated_effects_of_exercise_and_resveratrol_on_mitochondrial_biogenesis_ L2 - http://www.jbc.org/cgi/pmidlookup?view=long&pmid=23329826 DB - PRIME DP - Unbound Medicine ER -