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Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans.
Clin Endocrinol (Oxf). 2013 Sep; 79(3):364-70.CE

Abstract

OBJECTIVE

The purpose of this study was to investigate the impact of body mass index (BMI) and the presence of metabolic syndrome (MetS) on all-cause and cardiovascular mortality in elderly Korean men and women, and especially to compare metabolically obese normal-weight (MONW) and metabolically healthy obese (MHO) subjects.

PATIENTS AND METHODS

A total of 2317 elderly people (over 60 years of age) were studied using follow-up data from the South-West Seoul (SWS) Study, a prospective cohort study. Mortality from all causes and cardiovascular disease (CVD) were evaluated according to the combination of the presence or absence of MetS and Asian-specific body mass index (BMI) criteria (BMI <23 kg/m²; normal weight, BMI 23-24·9 kg/m²; overweight, BMI ≥25 kg/m²; obesity).

RESULTS

During a median follow-up of 10·3 years, 393 subjects died, including 126 from CVD. Among subjects with MetS, all-cause and CVD mortality were significantly higher in normal-weight subjects than overweight or obese individuals in Cox proportional-hazard models adjusted for confounding factors. Furthermore, among six groups with various MetS/BMI combinations, MONW individuals had the highest risk, whereas overweight subjects without MetS had the lowest risk of death from all causes and CVD [HR = 2·2 (95% CI = 1·4-3·4), HR = 3·0 (95% CI = 1·4-6·6) respectively]. Interestingly, all-cause mortality was significantly higher in MONW than MHO individuals.

CONCLUSIONS

In contrast to MHO subjects, elderly individuals with the MONW phenotype exhibited greater all-cause mortality during 10 years of follow-up.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23330616

Citation

Choi, Kyung Mook, et al. "Higher Mortality in Metabolically Obese Normal-weight People Than in Metabolically Healthy Obese Subjects in Elderly Koreans." Clinical Endocrinology, vol. 79, no. 3, 2013, pp. 364-70.
Choi KM, Cho HJ, Choi HY, et al. Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans. Clin Endocrinol (Oxf). 2013;79(3):364-70.
Choi, K. M., Cho, H. J., Choi, H. Y., Yang, S. J., Yoo, H. J., Seo, J. A., Kim, S. G., Baik, S. H., Choi, D. S., & Kim, N. H. (2013). Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans. Clinical Endocrinology, 79(3), 364-70. https://doi.org/10.1111/cen.12154
Choi KM, et al. Higher Mortality in Metabolically Obese Normal-weight People Than in Metabolically Healthy Obese Subjects in Elderly Koreans. Clin Endocrinol (Oxf). 2013;79(3):364-70. PubMed PMID: 23330616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher mortality in metabolically obese normal-weight people than in metabolically healthy obese subjects in elderly Koreans. AU - Choi,Kyung Mook, AU - Cho,Hyun Joo, AU - Choi,Hae Yoon, AU - Yang,Sae Jeong, AU - Yoo,Hye Jin, AU - Seo,Ji A, AU - Kim,Sin Gon, AU - Baik,Sei Hyun, AU - Choi,Dong Seop, AU - Kim,Nan Hee, Y1 - 2013/05/11/ PY - 2012/11/14/received PY - 2012/12/08/revised PY - 2012/12/27/revised PY - 2013/01/12/accepted PY - 2013/1/22/entrez PY - 2013/1/22/pubmed PY - 2014/2/25/medline SP - 364 EP - 70 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 79 IS - 3 N2 - OBJECTIVE: The purpose of this study was to investigate the impact of body mass index (BMI) and the presence of metabolic syndrome (MetS) on all-cause and cardiovascular mortality in elderly Korean men and women, and especially to compare metabolically obese normal-weight (MONW) and metabolically healthy obese (MHO) subjects. PATIENTS AND METHODS: A total of 2317 elderly people (over 60 years of age) were studied using follow-up data from the South-West Seoul (SWS) Study, a prospective cohort study. Mortality from all causes and cardiovascular disease (CVD) were evaluated according to the combination of the presence or absence of MetS and Asian-specific body mass index (BMI) criteria (BMI <23 kg/m²; normal weight, BMI 23-24·9 kg/m²; overweight, BMI ≥25 kg/m²; obesity). RESULTS: During a median follow-up of 10·3 years, 393 subjects died, including 126 from CVD. Among subjects with MetS, all-cause and CVD mortality were significantly higher in normal-weight subjects than overweight or obese individuals in Cox proportional-hazard models adjusted for confounding factors. Furthermore, among six groups with various MetS/BMI combinations, MONW individuals had the highest risk, whereas overweight subjects without MetS had the lowest risk of death from all causes and CVD [HR = 2·2 (95% CI = 1·4-3·4), HR = 3·0 (95% CI = 1·4-6·6) respectively]. Interestingly, all-cause mortality was significantly higher in MONW than MHO individuals. CONCLUSIONS: In contrast to MHO subjects, elderly individuals with the MONW phenotype exhibited greater all-cause mortality during 10 years of follow-up. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/23330616/Higher_mortality_in_metabolically_obese_normal_weight_people_than_in_metabolically_healthy_obese_subjects_in_elderly_Koreans_ L2 - https://doi.org/10.1111/cen.12154 DB - PRIME DP - Unbound Medicine ER -