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Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: a case-control study.
Parkinsonism Relat Disord. 2013 Apr; 19(4):426-30.PR

Abstract

BACKGROUND

Restless Legs Syndrome (RLS) is associated with impaired central dopaminergic neurotransmission. Though a link between RLS and parkinsonism has been proposed, the prevalence of RLS in parkinsonian disorders is poorly documented.

OBJECTIVE

To determine the prevalence of RLS in patients with Parkinson's Disease (PD), Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA) and Dementia with Lewy Bodies (DLB).

METHODS

We evaluated 187 consecutive patients with parkinsonian disorders (PD = 134, PSP = 27, MSA = 21, DLB = 5) and 172 healthy controls. RLS was diagnosed using the International RLS Study Group (IRLSSG) criteria and the severity of RLS was assessed in patients with definite RLS. Quality of sleep was evaluated with established scales.

RESULTS

The prevalence of RLS was higher in patients compared to controls (9.6% vs. 2.9%; p = 0.009) and was highest in PD (11.9%). RLS was present in only one patient each with MSA and PSP and none with DLB. The mean IRLSSG severity score of patients was 16.2 ± 6.5. The global Pittsburgh Sleep Quality Index score and Epworth Sleepiness Scale score were significantly higher in patients compared to controls (p < 0.001). PD patients with RLS had lower Parkinson's Disease Sleep Scale (PDSS) score compared to patients without RLS (p = 0.023). There was no significant difference in gender, age, duration and severity of PD between the two groups.

CONCLUSIONS

Our study found a higher prevalence of RLS in PD compared to healthy controls or other parkinsonian disorders. Apart from PDSS score, there was no significant difference in the clinical characteristics of PD patients with and without RLS.

Authors+Show Affiliations

Department of Neurology, National Institute of Mental Health & Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23333538

Citation

Bhalsing, Ketaki, et al. "Prevalence and Profile of Restless Legs Syndrome in Parkinson's Disease and Other Neurodegenerative Disorders: a Case-control Study." Parkinsonism & Related Disorders, vol. 19, no. 4, 2013, pp. 426-30.
Bhalsing K, Suresh K, Muthane UB, et al. Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: a case-control study. Parkinsonism Relat Disord. 2013;19(4):426-30.
Bhalsing, K., Suresh, K., Muthane, U. B., & Pal, P. K. (2013). Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: a case-control study. Parkinsonism & Related Disorders, 19(4), 426-30. https://doi.org/10.1016/j.parkreldis.2012.12.005
Bhalsing K, et al. Prevalence and Profile of Restless Legs Syndrome in Parkinson's Disease and Other Neurodegenerative Disorders: a Case-control Study. Parkinsonism Relat Disord. 2013;19(4):426-30. PubMed PMID: 23333538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: a case-control study. AU - Bhalsing,Ketaki, AU - Suresh,K, AU - Muthane,Uday B, AU - Pal,Pramod Kr, Y1 - 2013/01/18/ PY - 2012/08/30/received PY - 2012/12/08/revised PY - 2012/12/31/accepted PY - 2013/1/22/entrez PY - 2013/1/22/pubmed PY - 2013/9/7/medline SP - 426 EP - 30 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 19 IS - 4 N2 - BACKGROUND: Restless Legs Syndrome (RLS) is associated with impaired central dopaminergic neurotransmission. Though a link between RLS and parkinsonism has been proposed, the prevalence of RLS in parkinsonian disorders is poorly documented. OBJECTIVE: To determine the prevalence of RLS in patients with Parkinson's Disease (PD), Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA) and Dementia with Lewy Bodies (DLB). METHODS: We evaluated 187 consecutive patients with parkinsonian disorders (PD = 134, PSP = 27, MSA = 21, DLB = 5) and 172 healthy controls. RLS was diagnosed using the International RLS Study Group (IRLSSG) criteria and the severity of RLS was assessed in patients with definite RLS. Quality of sleep was evaluated with established scales. RESULTS: The prevalence of RLS was higher in patients compared to controls (9.6% vs. 2.9%; p = 0.009) and was highest in PD (11.9%). RLS was present in only one patient each with MSA and PSP and none with DLB. The mean IRLSSG severity score of patients was 16.2 ± 6.5. The global Pittsburgh Sleep Quality Index score and Epworth Sleepiness Scale score were significantly higher in patients compared to controls (p < 0.001). PD patients with RLS had lower Parkinson's Disease Sleep Scale (PDSS) score compared to patients without RLS (p = 0.023). There was no significant difference in gender, age, duration and severity of PD between the two groups. CONCLUSIONS: Our study found a higher prevalence of RLS in PD compared to healthy controls or other parkinsonian disorders. Apart from PDSS score, there was no significant difference in the clinical characteristics of PD patients with and without RLS. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/23333538/Prevalence_and_profile_of_Restless_Legs_Syndrome_in_Parkinson's_disease_and_other_neurodegenerative_disorders:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(13)00002-3 DB - PRIME DP - Unbound Medicine ER -