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Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment.
Mycotoxin Res. 2013 Feb; 29(1):47-54.MR

Abstract

Chaetomium globosum is one of the most common species of fungi found growing on damp building materials in North America and Europe. At doses that could be experienced in a building with some mould damage, exposure to metabolites from other fungi results in inflammatory changes in vivo and in vitro. This research requires knowledge of the dominant toxins produced by fungal strains from the built environment and characterization of pure compounds for toxicity testing. We examined 25 strains of C. globosum isolated from the built environment in Canada. In varying amounts, these strains primarily produced chaetoglobosin A, C and F, chaetomugilin D, and chaetoviridin A. Spectroscopic data of the major isolated compounds are provided. Previous studies reported a number of metabolites from this species that we did not find. However, this appears to be due to misidentifications of the fungi they examined as well as problems with the analytical methods used. In addition, our data support the use of metabolite profiles for resolving the taxonomy of some economically important Chaetomium species.

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Publisher Full Text (DOI)

Authors+Show Affiliations

McMullin DR
Ottawa Carleton Institute of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada.
Sumarah MW
No affiliation info available
Miller JD
No affiliation info available

MeSH

BenzopyransCanadaChaetomiumConstruction MaterialsDNA, FungalDNA, Ribosomal SpacerEnvironmental MicrobiologyIndole AlkaloidsMolecular Sequence DataPigments, BiologicalSequence Analysis, DNASpectrum Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23334724

Citation

McMullin, David R., et al. "Chaetoglobosins and Azaphilones Produced By Canadian Strains of Chaetomium Globosum Isolated From the Indoor Environment." Mycotoxin Research, vol. 29, no. 1, 2013, pp. 47-54.
McMullin DR, Sumarah MW, Miller JD. Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. Mycotoxin Res. 2013;29(1):47-54.
McMullin, D. R., Sumarah, M. W., & Miller, J. D. (2013). Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. Mycotoxin Research, 29(1), 47-54. https://doi.org/10.1007/s12550-012-0144-9
McMullin DR, Sumarah MW, Miller JD. Chaetoglobosins and Azaphilones Produced By Canadian Strains of Chaetomium Globosum Isolated From the Indoor Environment. Mycotoxin Res. 2013;29(1):47-54. PubMed PMID: 23334724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. AU - McMullin,David R, AU - Sumarah,Mark W, AU - Miller,J David, Y1 - 2012/10/17/ PY - 2012/08/11/received PY - 2012/09/07/accepted PY - 2012/09/07/revised PY - 2013/1/22/entrez PY - 2013/1/22/pubmed PY - 2013/8/13/medline SP - 47 EP - 54 JF - Mycotoxin research JO - Mycotoxin Res VL - 29 IS - 1 N2 - Chaetomium globosum is one of the most common species of fungi found growing on damp building materials in North America and Europe. At doses that could be experienced in a building with some mould damage, exposure to metabolites from other fungi results in inflammatory changes in vivo and in vitro. This research requires knowledge of the dominant toxins produced by fungal strains from the built environment and characterization of pure compounds for toxicity testing. We examined 25 strains of C. globosum isolated from the built environment in Canada. In varying amounts, these strains primarily produced chaetoglobosin A, C and F, chaetomugilin D, and chaetoviridin A. Spectroscopic data of the major isolated compounds are provided. Previous studies reported a number of metabolites from this species that we did not find. However, this appears to be due to misidentifications of the fungi they examined as well as problems with the analytical methods used. In addition, our data support the use of metabolite profiles for resolving the taxonomy of some economically important Chaetomium species. SN - 1867-1632 UR - https://www.unboundmedicine.com/medline/citation/23334724/Chaetoglobosins_and_azaphilones_produced_by_Canadian_strains_of_Chaetomium_globosum_isolated_from_the_indoor_environment_ L2 - https://dx.doi.org/10.1007/s12550-012-0144-9 DB - PRIME DP - Unbound Medicine ER -