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Simultaneous determination of quinoxaline-1,4-dioxides in feeds using molecularly imprinted solid-phase extraction coupled with HPLC.
J Sep Sci. 2013 Jan; 36(2):301-10.JS

Abstract

A simple, selective, and reproducible molecularly imprinted SPE coupled with HPLC method was developed for monitoring quinoxaline-1,4-dioxides in feeds. Molecularly imprinted polymers were synthesized in methanol using mequindox (MEQ) as template molecule and acrylamide as functional monomer by bulk polymerization. Under the optimum SPE conditions, the novel polymer sorbents can selectively extract and enrich carbadox, MEQ, quinocetone, and cyadox from a variety of feeds. The molecularly imprinted SPE cartridge was better than nonimprinted, C(18) , and HLB cartridges in terms of both recovery and precision. Mean recoveries of four quinoxaline-1,4-dioxides from six kinds of feeds spiked at 1.0, 10, and 100 mg/kg ranged between 75.2 and 94.7% with RSDs of less than 10%. The decision limits (CCαs) and the detection capabilities (CCβs) of four analytes were 0.15-0.20 mg/kg and 0.44-0.56 mg/kg, respectively. The class selectivity of the polymers was evaluated by checking three drugs with different molecular structures to that of MEQ.

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Publisher Full Text (DOI)

Authors+Show Affiliations

He Q
National Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Fang B
No affiliation info available
Su Y
No affiliation info available
Zeng Z
No affiliation info available
Yang J
No affiliation info available
He L
No affiliation info available
Zeng D
No affiliation info available

MeSH

AdsorptionAnimal FeedAnti-Bacterial AgentsFood ContaminationMolecular ImprintingPolymersQuinoxalinesSolid Phase Extraction

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23335457

Citation

He, Qianqian, et al. "Simultaneous Determination of Quinoxaline-1,4-dioxides in Feeds Using Molecularly Imprinted Solid-phase Extraction Coupled With HPLC." Journal of Separation Science, vol. 36, no. 2, 2013, pp. 301-10.
He Q, Fang B, Su Y, et al. Simultaneous determination of quinoxaline-1,4-dioxides in feeds using molecularly imprinted solid-phase extraction coupled with HPLC. J Sep Sci. 2013;36(2):301-10.
He, Q., Fang, B., Su, Y., Zeng, Z., Yang, J., He, L., & Zeng, D. (2013). Simultaneous determination of quinoxaline-1,4-dioxides in feeds using molecularly imprinted solid-phase extraction coupled with HPLC. Journal of Separation Science, 36(2), 301-10. https://doi.org/10.1002/jssc.201200701
He Q, et al. Simultaneous Determination of Quinoxaline-1,4-dioxides in Feeds Using Molecularly Imprinted Solid-phase Extraction Coupled With HPLC. J Sep Sci. 2013;36(2):301-10. PubMed PMID: 23335457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous determination of quinoxaline-1,4-dioxides in feeds using molecularly imprinted solid-phase extraction coupled with HPLC. AU - He,Qianqian, AU - Fang,Binghu, AU - Su,Yijuan, AU - Zeng,Zhenling, AU - Yang,Jianwen, AU - He,Limin, AU - Zeng,Dongping, Y1 - 2012/12/10/ PY - 2012/07/23/received PY - 2012/09/10/revised PY - 2012/09/14/accepted PY - 2013/1/22/entrez PY - 2013/1/22/pubmed PY - 2013/6/26/medline SP - 301 EP - 10 JF - Journal of separation science JO - J Sep Sci VL - 36 IS - 2 N2 - A simple, selective, and reproducible molecularly imprinted SPE coupled with HPLC method was developed for monitoring quinoxaline-1,4-dioxides in feeds. Molecularly imprinted polymers were synthesized in methanol using mequindox (MEQ) as template molecule and acrylamide as functional monomer by bulk polymerization. Under the optimum SPE conditions, the novel polymer sorbents can selectively extract and enrich carbadox, MEQ, quinocetone, and cyadox from a variety of feeds. The molecularly imprinted SPE cartridge was better than nonimprinted, C(18) , and HLB cartridges in terms of both recovery and precision. Mean recoveries of four quinoxaline-1,4-dioxides from six kinds of feeds spiked at 1.0, 10, and 100 mg/kg ranged between 75.2 and 94.7% with RSDs of less than 10%. The decision limits (CCαs) and the detection capabilities (CCβs) of four analytes were 0.15-0.20 mg/kg and 0.44-0.56 mg/kg, respectively. The class selectivity of the polymers was evaluated by checking three drugs with different molecular structures to that of MEQ. SN - 1615-9314 UR - https://www.unboundmedicine.com/medline/citation/23335457/Simultaneous_determination_of_quinoxaline_14_dioxides_in_feeds_using_molecularly_imprinted_solid_phase_extraction_coupled_with_HPLC_ L2 - https://doi.org/10.1002/jssc.201200701 DB - PRIME DP - Unbound Medicine ER -