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[Anti-MOG antibody in different types of immune-mediated optic neuritis].
Zhonghua Yan Ke Za Zhi 2012; 48(12):1069-72ZY

Abstract

OBJECTIVE

To investigate the expression of anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in different types of immune-mediated optic neuritis (IM-ON).

METHODS

Case-control and cross section study. The serum of 129 consecutive cases of immune-mediated optic neuritis (IM-ON group) seen in Neuro-ophthalmology clinic in Department of Neurology, Beijing Tongren Hospital during May 2010 and February 2011 were collected. All IM-ON cases were further classified into five different types as: 20 cases of multiple sclerosis related ON (MS-ON), 13 cases of neuromyelitis optical related ON (NMO-ON), 33 cases of autoimmune optic neuritis (AON), 43 cases of relapsing isolated optic neuritis (RION) and 20 cases of solitary isolated optic neuritis (SION). MOG-Ab was tested by ELISA. The positivity rate and titer of MOG-Ab among these groups were compared using chi-square test and ANOVA, t test by SPSS17.0 software.

RESULTS

MOG-Ab was positive in 12 of all 129 tested IM-ON patients (9.3%), in which there were 5 of 20 MS-ON, none of 13 NMO-ON, 4 of 33 AON, 2 of 43 RION, and 1 of 20 SION patients. There were no statistical significant difference among five groups (Fisher's exact test, χ(2) = 7.051, P = 0.088), but MS-ON group showed statistically higher MOG-Ab positivity and titer than the "NMO spectrum optic neuritis" group which was merged from the other 4 IM-ON groups.

CONCLUSION

MOG-Ab could be detected in different types of immune-mediated optic neuritis except NMO-ON and the expression of MOG-Ab was statistically higher in MS-ON group than the 'NMO spectrum optic neuritis' group.

Authors+Show Affiliations

Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

23336409

Citation

Kong, Xiu-yun, et al. "[Anti-MOG Antibody in Different Types of Immune-mediated Optic Neuritis]." [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, vol. 48, no. 12, 2012, pp. 1069-72.
Kong XY, Peng JT, Liu LJ, et al. [Anti-MOG antibody in different types of immune-mediated optic neuritis]. Zhonghua Yan Ke Za Zhi. 2012;48(12):1069-72.
Kong, X. Y., Peng, J. T., Liu, L. J., Yan, R., & Zhang, X. J. (2012). [Anti-MOG antibody in different types of immune-mediated optic neuritis]. [Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology, 48(12), pp. 1069-72.
Kong XY, et al. [Anti-MOG Antibody in Different Types of Immune-mediated Optic Neuritis]. Zhonghua Yan Ke Za Zhi. 2012;48(12):1069-72. PubMed PMID: 23336409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-MOG antibody in different types of immune-mediated optic neuritis]. AU - Kong,Xiu-yun, AU - Peng,Jing-ting, AU - Liu,Li-juan, AU - Yan,Rong, AU - Zhang,Xiao-jun, PY - 2013/1/23/entrez PY - 2013/1/23/pubmed PY - 2013/11/15/medline SP - 1069 EP - 72 JF - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology JO - Zhonghua Yan Ke Za Zhi VL - 48 IS - 12 N2 - OBJECTIVE: To investigate the expression of anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab) in different types of immune-mediated optic neuritis (IM-ON). METHODS: Case-control and cross section study. The serum of 129 consecutive cases of immune-mediated optic neuritis (IM-ON group) seen in Neuro-ophthalmology clinic in Department of Neurology, Beijing Tongren Hospital during May 2010 and February 2011 were collected. All IM-ON cases were further classified into five different types as: 20 cases of multiple sclerosis related ON (MS-ON), 13 cases of neuromyelitis optical related ON (NMO-ON), 33 cases of autoimmune optic neuritis (AON), 43 cases of relapsing isolated optic neuritis (RION) and 20 cases of solitary isolated optic neuritis (SION). MOG-Ab was tested by ELISA. The positivity rate and titer of MOG-Ab among these groups were compared using chi-square test and ANOVA, t test by SPSS17.0 software. RESULTS: MOG-Ab was positive in 12 of all 129 tested IM-ON patients (9.3%), in which there were 5 of 20 MS-ON, none of 13 NMO-ON, 4 of 33 AON, 2 of 43 RION, and 1 of 20 SION patients. There were no statistical significant difference among five groups (Fisher's exact test, χ(2) = 7.051, P = 0.088), but MS-ON group showed statistically higher MOG-Ab positivity and titer than the "NMO spectrum optic neuritis" group which was merged from the other 4 IM-ON groups. CONCLUSION: MOG-Ab could be detected in different types of immune-mediated optic neuritis except NMO-ON and the expression of MOG-Ab was statistically higher in MS-ON group than the 'NMO spectrum optic neuritis' group. SN - 0412-4081 UR - https://www.unboundmedicine.com/medline/citation/23336409/[Anti_MOG_antibody_in_different_types_of_immune_mediated_optic_neuritis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0412-4081&year=2012&vol=48&issue=12&fpage=1069 DB - PRIME DP - Unbound Medicine ER -