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Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach.
Pharm Biol. 2013 Apr; 51(4):426-32.PB

Abstract

CONTEXT

Pisonia aculeata leaves (Nyctagenaceae), a Folk medicinal plant used in the treatment of several inflammation, pain, and oxidative stress associated diseases.

OBJECTIVE

To evaluate anti-inflammatory, analgesic, and antioxidant potential of crude methanol extract of P. aculeata leaves (MEPA).

MATERIALS AND METHODS

Analgesic and anti-inflammatory activities of MEPA (250 and 500 mg/kg) were evaluated using writhing, formalin, hot plate, tail flick, carrageenan-induced paw edema test, and membrane stabilizing activity. Free radical scavenging activity, total phenolic and flavonoid contents of MEPA were also determined using standard methods.

RESULTS

Oral administration of MEPA showed significant (p < 0.001) inhibition of paw edema, pronounced at 4 h and 5 h after carrageenan injection, and at 200 µg/mL exerts 77.67 and 38.51% protective effect against hypotonic solution and heat induced hemolysis, respectively. MEPA (250 and 500 mg/kg) produced 35.21 and 79.14% inhibition of acetic acid-induced writhing. Furthermore, MEPA (500 mg/kg) inhibited 49.19% early and 73.14% late phase of formalin-induced hypernociception. In contrast, a lower dose of MEPA did not prevent hot plate induced nociception, while in the tail immersion method, pronounced analgesic activity was observed between 1 and 4 h postdosing. The extract possesses significant in vitro antioxidant activity and a lipid peroxidation inhibition effect. Total phenolic and total flavonoid content in MEPA were 87.99 ± 0.87 mg GAE/g and 58.98 ± 0.01 mg QE/g, respectively.

DISCUSSION AND CONCLUSION

Our findings confirmed the analgesic, anti-inflammatory and antioxidant activities of Pisonia aculeata leaves. Contents of flavonoids and phenolic compounds in extract could be correlated with its observed biological activities.

Authors+Show Affiliations

Department of Pharmacology, Creative Educational Society's College of Pharmacy, Chinnatekur, Kurnool, Andhra Pradesh-518218, India. saikat.pharm@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23336600

Citation

Sen, Saikat, et al. "Anti-inflammatory, Analgesic, and Antioxidant Activities of Pisonia Aculeata: Folk Medicinal Use to Scientific Approach." Pharmaceutical Biology, vol. 51, no. 4, 2013, pp. 426-32.
Sen S, Chakraborty R, Rekha B, et al. Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach. Pharm Biol. 2013;51(4):426-32.
Sen, S., Chakraborty, R., Rekha, B., Revathi, D., Ayyanna, S. C., Hemalatha, G., Kumar Reddy, G. A., Hyndavi, S., Ikhyatha Babu, P. J., Prakash, P. R., & Sridhar, C. (2013). Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach. Pharmaceutical Biology, 51(4), 426-32. https://doi.org/10.3109/13880209.2012.738331
Sen S, et al. Anti-inflammatory, Analgesic, and Antioxidant Activities of Pisonia Aculeata: Folk Medicinal Use to Scientific Approach. Pharm Biol. 2013;51(4):426-32. PubMed PMID: 23336600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach. AU - Sen,Saikat, AU - Chakraborty,Raja, AU - Rekha,B, AU - Revathi,D, AU - Ayyanna,S Chinna, AU - Hemalatha,G, AU - Kumar Reddy,G Ashok, AU - Hyndavi,S, AU - Ikhyatha Babu,P Jeevan, AU - Prakash,P Ravi, AU - Sridhar,C, Y1 - 2013/01/22/ PY - 2013/1/23/entrez PY - 2013/1/23/pubmed PY - 2013/8/31/medline SP - 426 EP - 32 JF - Pharmaceutical biology JO - Pharm Biol VL - 51 IS - 4 N2 - CONTEXT: Pisonia aculeata leaves (Nyctagenaceae), a Folk medicinal plant used in the treatment of several inflammation, pain, and oxidative stress associated diseases. OBJECTIVE: To evaluate anti-inflammatory, analgesic, and antioxidant potential of crude methanol extract of P. aculeata leaves (MEPA). MATERIALS AND METHODS: Analgesic and anti-inflammatory activities of MEPA (250 and 500 mg/kg) were evaluated using writhing, formalin, hot plate, tail flick, carrageenan-induced paw edema test, and membrane stabilizing activity. Free radical scavenging activity, total phenolic and flavonoid contents of MEPA were also determined using standard methods. RESULTS: Oral administration of MEPA showed significant (p < 0.001) inhibition of paw edema, pronounced at 4 h and 5 h after carrageenan injection, and at 200 µg/mL exerts 77.67 and 38.51% protective effect against hypotonic solution and heat induced hemolysis, respectively. MEPA (250 and 500 mg/kg) produced 35.21 and 79.14% inhibition of acetic acid-induced writhing. Furthermore, MEPA (500 mg/kg) inhibited 49.19% early and 73.14% late phase of formalin-induced hypernociception. In contrast, a lower dose of MEPA did not prevent hot plate induced nociception, while in the tail immersion method, pronounced analgesic activity was observed between 1 and 4 h postdosing. The extract possesses significant in vitro antioxidant activity and a lipid peroxidation inhibition effect. Total phenolic and total flavonoid content in MEPA were 87.99 ± 0.87 mg GAE/g and 58.98 ± 0.01 mg QE/g, respectively. DISCUSSION AND CONCLUSION: Our findings confirmed the analgesic, anti-inflammatory and antioxidant activities of Pisonia aculeata leaves. Contents of flavonoids and phenolic compounds in extract could be correlated with its observed biological activities. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/23336600/Anti_inflammatory_analgesic_and_antioxidant_activities_of_Pisonia_aculeata:_folk_medicinal_use_to_scientific_approach_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2012.738331 DB - PRIME DP - Unbound Medicine ER -