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Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response.
J Immunol. 2013 Mar 01; 190(5):2150-8.JI

Abstract

The live attenuated yellow fever virus (YFV) 17D vaccine provides a good model to study immune responses to an acute viral infection in humans. We studied the temporal dynamics, composition, and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell response was broad and complex; it was composed of dominant responses that persisted into the memory population, as well as of transient subdominant responses that were not detected at the memory stage. Furthermore, HLA-A2- and HLA-B7-restricted YFV epitope-specific effector cells predominantly displayed a CD45RA(-)CCR7(-)PD-1(+)CD27(high) phenotype, which transitioned into a CD45RA(+)CCR7(-)PD-1(-)CD27(low) memory population phenotype. The functional profile of the YFV-specific CD8 T cell response changed in composition as it matured from an effector- to a memory-type response, and it tended to become less polyfunctional during the course of this transition. Interestingly, activation of CD4 T cells, as well as FOXP3(+) T regulatory cells, in response to YFV vaccination preceded the kinetics of the CD8 T cell response. The present results contribute to our understanding of how immunodominance patterns develop, as well as the phenotypic and functional characteristics of the primary human T cell response to a viral infection as it evolves and matures into memory.

Authors+Show Affiliations

Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23338234

Citation

Blom, Kim, et al. "Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D as It Matures From an Effector- to a Memory-type Response." Journal of Immunology (Baltimore, Md. : 1950), vol. 190, no. 5, 2013, pp. 2150-8.
Blom K, Braun M, Ivarsson MA, et al. Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. J Immunol. 2013;190(5):2150-8.
Blom, K., Braun, M., Ivarsson, M. A., Gonzalez, V. D., Falconer, K., Moll, M., Ljunggren, H. G., Michaëlsson, J., & Sandberg, J. K. (2013). Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. Journal of Immunology (Baltimore, Md. : 1950), 190(5), 2150-8. https://doi.org/10.4049/jimmunol.1202234
Blom K, et al. Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D as It Matures From an Effector- to a Memory-type Response. J Immunol. 2013 Mar 1;190(5):2150-8. PubMed PMID: 23338234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. AU - Blom,Kim, AU - Braun,Monika, AU - Ivarsson,Martin A, AU - Gonzalez,Veronica D, AU - Falconer,Karolin, AU - Moll,Markus, AU - Ljunggren,Hans-Gustaf, AU - Michaëlsson,Jakob, AU - Sandberg,Johan K, Y1 - 2013/01/21/ PY - 2013/1/23/entrez PY - 2013/1/23/pubmed PY - 2013/4/6/medline SP - 2150 EP - 8 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 190 IS - 5 N2 - The live attenuated yellow fever virus (YFV) 17D vaccine provides a good model to study immune responses to an acute viral infection in humans. We studied the temporal dynamics, composition, and character of the primary human T cell response to YFV. The acute YFV-specific effector CD8 T cell response was broad and complex; it was composed of dominant responses that persisted into the memory population, as well as of transient subdominant responses that were not detected at the memory stage. Furthermore, HLA-A2- and HLA-B7-restricted YFV epitope-specific effector cells predominantly displayed a CD45RA(-)CCR7(-)PD-1(+)CD27(high) phenotype, which transitioned into a CD45RA(+)CCR7(-)PD-1(-)CD27(low) memory population phenotype. The functional profile of the YFV-specific CD8 T cell response changed in composition as it matured from an effector- to a memory-type response, and it tended to become less polyfunctional during the course of this transition. Interestingly, activation of CD4 T cells, as well as FOXP3(+) T regulatory cells, in response to YFV vaccination preceded the kinetics of the CD8 T cell response. The present results contribute to our understanding of how immunodominance patterns develop, as well as the phenotypic and functional characteristics of the primary human T cell response to a viral infection as it evolves and matures into memory. SN - 1550-6606 UR - https://www.unboundmedicine.com/medline/citation/23338234/Temporal_dynamics_of_the_primary_human_T_cell_response_to_yellow_fever_virus_17D_as_it_matures_from_an_effector__to_a_memory_type_response_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=23338234 DB - PRIME DP - Unbound Medicine ER -