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Does milk cause constipation? A crossover dietary trial.
Nutrients 2013; 5(1):253-66N

Abstract

The aims of this study were to: (1) determine whether replacement of cow's milk protein with soy resolves Chronic Functional Constipation (CFC); and (2) investigate the effects of cow's milk β casein A1 and cow's milk β casein A2 on CFC. Children diagnosed with CFC were recruited to one of two crossover trials: Trial 1 compared the effects of cow's milk and soy milk; Trial 2 compared the effects of cow's milk β casein A1 and cow's milk β casein A2. Resolution of constipation was defined as greater than eight bowel motions during a two week intervention. Thirteen children (18 to 144 months) participated in Trial 1 (6 boys, 7 girls). Nine participants who completed the soy epoch all experienced resolution (p < 0.05). Thirty-nine children (21 to 144 months) participated in Trial 2 (25 boys, 14 girls). Resolution of constipation was highest during the washout epoch, 81%; followed by cow's milk β casein A2, 79%; and cow's milk β casein A1, 57%; however, the proportions did not differ statistically. The results of Trial 1 demonstrate an association between CFC and cow's milk consumption but Trial 2 failed to show an effect from type of casein. Some other component in cow's milk common to both A1 and A2 milk may be causing a problem in these susceptible children.

Authors+Show Affiliations

Department of Rural Health NSW, University of Newcastle, Tamworth, NSW 2340, Australia. elesa.crowley@hnehealth.nsw.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23340316

Citation

Crowley, Elesa T., et al. "Does Milk Cause Constipation? a Crossover Dietary Trial." Nutrients, vol. 5, no. 1, 2013, pp. 253-66.
Crowley ET, Williams LT, Roberts TK, et al. Does milk cause constipation? A crossover dietary trial. Nutrients. 2013;5(1):253-66.
Crowley, E. T., Williams, L. T., Roberts, T. K., Dunstan, R. H., & Jones, P. D. (2013). Does milk cause constipation? A crossover dietary trial. Nutrients, 5(1), pp. 253-66. doi:10.3390/nu5010253.
Crowley ET, et al. Does Milk Cause Constipation? a Crossover Dietary Trial. Nutrients. 2013 Jan 22;5(1):253-66. PubMed PMID: 23340316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does milk cause constipation? A crossover dietary trial. AU - Crowley,Elesa T, AU - Williams,Lauren T, AU - Roberts,Tim K, AU - Dunstan,Richard H, AU - Jones,Peter D, Y1 - 2013/01/22/ PY - 2012/10/22/received PY - 2012/11/26/revised PY - 2012/12/20/accepted PY - 2013/1/24/entrez PY - 2013/1/24/pubmed PY - 2013/6/12/medline SP - 253 EP - 66 JF - Nutrients JO - Nutrients VL - 5 IS - 1 N2 - The aims of this study were to: (1) determine whether replacement of cow's milk protein with soy resolves Chronic Functional Constipation (CFC); and (2) investigate the effects of cow's milk β casein A1 and cow's milk β casein A2 on CFC. Children diagnosed with CFC were recruited to one of two crossover trials: Trial 1 compared the effects of cow's milk and soy milk; Trial 2 compared the effects of cow's milk β casein A1 and cow's milk β casein A2. Resolution of constipation was defined as greater than eight bowel motions during a two week intervention. Thirteen children (18 to 144 months) participated in Trial 1 (6 boys, 7 girls). Nine participants who completed the soy epoch all experienced resolution (p < 0.05). Thirty-nine children (21 to 144 months) participated in Trial 2 (25 boys, 14 girls). Resolution of constipation was highest during the washout epoch, 81%; followed by cow's milk β casein A2, 79%; and cow's milk β casein A1, 57%; however, the proportions did not differ statistically. The results of Trial 1 demonstrate an association between CFC and cow's milk consumption but Trial 2 failed to show an effect from type of casein. Some other component in cow's milk common to both A1 and A2 milk may be causing a problem in these susceptible children. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/23340316/full_citation L2 - http://www.mdpi.com/resolver?pii=nu5010253 DB - PRIME DP - Unbound Medicine ER -